STRINGSTRING
SOCS5 SOCS5 CYP17A1 CYP17A1 STAT5B STAT5B STAT3 STAT3 MAPK10 MAPK10 HRAS HRAS AKT3 AKT3 SHC3 SHC3 AKT1 AKT1 TNFSF11 TNFSF11 NFKB1 NFKB1 SOCS6 SOCS6 LHCGR LHCGR PIK3R1 PIK3R1 MAPK11 MAPK11 IRF1 IRF1 MAP2K2 MAP2K2 GCK GCK PRL PRL SHC2 SHC2 KRAS KRAS SOCS3 SOCS3 ESR1 ESR1 MAP2K1 MAP2K1 SOS1 SOS1 FOXO3 FOXO3 PIK3CD PIK3CD GRB2 GRB2 MAPK14 MAPK14 LHB LHB SOS2 SOS2 MAPK1 MAPK1 CGA CGA PRLR PRLR PIK3CB PIK3CB ELF5 ELF5 SHC4 SHC4 SOCS4 SOCS4 MAPK12 MAPK12 RAF1 RAF1 NRAS NRAS MAPK3 MAPK3 SOCS7 SOCS7 PIK3CA PIK3CA MAPK8 MAPK8 CRADD CRADD TH TH SRC SRC CCND2 CCND2 ESR2 ESR2 PIK3R2 PIK3R2 GSK3B GSK3B FOS FOS PIK3R3 PIK3R3 MAPK9 MAPK9 SOCS1 SOCS1 RELA RELA JAK2 JAK2 CISH CISH STAT1 STAT1 CCND1 CCND1 STAT5A STAT5A SLC2A2 SLC2A2 AKT2 AKT2 TNFRSF11A TNFRSF11A LOC101100876 LOC101100876 GALT GALT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOCS5Suppressor of cytokine signaling 5. (536 aa)
CYP17A1Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (508 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SHC3SHC adaptor protein 3. (587 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
NFKB1Nuclear factor kappa B subunit 1. (989 aa)
SOCS6Suppressor of cytokine signaling 6. (497 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (700 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
IRF1Interferon regulatory factor. (322 aa)
MAP2K2Protein kinase domain-containing protein. (549 aa)
GCKPhosphotransferase. (466 aa)
PRLProlactin; Prolactin acts primarily on the mammary gland by promoting lactation. (229 aa)
SHC2SHC adaptor protein 2. (583 aa)
KRASUncharacterized protein. (380 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
FOXO3Forkhead box O3. (672 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LHBLutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. (143 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
CGAGlycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (152 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (624 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
ELF5E74 like ETS transcription factor 5. (275 aa)
SHC4SHC adaptor protein 4. (630 aa)
SOCS4Suppressor of cytokine signaling 4. (441 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
SOCS7Suppressor of cytokine signaling 7. (640 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CRADDUncharacterized protein. (398 aa)
THInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (557 aa)
SRCTyrosine-protein kinase. (678 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
ESR2Estrogen receptor 2. (574 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
GSK3BProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
PIK3R3Uncharacterized protein. (461 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
SOCS1Suppressor of cytokine signaling 1. (203 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
CISHCytokine inducible SH2 containing protein. (257 aa)
STAT1Signal transducer and activator of transcription. (885 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (571 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
TNFRSF11ATNF receptor superfamily member 11a. (638 aa)
LOC101100876Uncharacterized protein. (127 aa)
GALTGalactose-1-phosphate uridylyltransferase; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. (460 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.