STRINGSTRING
MTOR MTOR TRAF2 TRAF2 PCK1 PCK1 IRS4 IRS4 PRKAB1 PRKAB1 STAT3 STAT3 G6PC3 G6PC3 MAPK10 MAPK10 SLC2A4 SLC2A4 NFKBIB NFKBIB POMC POMC AKT3 AKT3 TNFRSF1B TNFRSF1B AKT1 AKT1 ACSL1 ACSL1 PPARA PPARA ACSBG1 ACSBG1 CPT1C CPT1C G6PC2 G6PC2 NFKBIA NFKBIA TNFRSF1A TNFRSF1A NFKB1 NFKB1 ACACB ACACB RXRG RXRG ACSL3 ACSL3 STK11 STK11 ADIPOQ ADIPOQ IRS1 IRS1 SOCS3 SOCS3 IKBKG IKBKG LOC101100432 LOC101100432 ADIPOR2 ADIPOR2 PRKAA1 PRKAA1 G6PC G6PC PRKAG3 PRKAG3 CPT1B CPT1B PTPN11 PTPN11 CD36 CD36 AGRP AGRP PRKAG1 PRKAG1 LEP LEP ACSL4 ACSL4 PRKAA2 PRKAA2 PRKAB2 PRKAB2 MAPK8 MAPK8 LEPR LEPR PRKCQ PRKCQ ACSL6 ACSL6 LOC101085801 LOC101085801 IKBKB IKBKB TRADD TRADD IRS2 IRS2 PCK2 PCK2 MAPK9 MAPK9 RELA RELA NFKBIE NFKBIE RXRA RXRA JAK2 JAK2 TNF TNF SLC2A1 SLC2A1 ACSL5 ACSL5 CPT1A CPT1A LOC102900010 LOC102900010 PPARGC1A PPARGC1A CAMKK2 CAMKK2 AKT2 AKT2 CHUK CHUK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
IRS4Insulin receptor substrate 4. (1251 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (585 aa)
NFKBIBNFKB inhibitor beta. (354 aa)
POMCProopiomelanocortin. (258 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TNFRSF1BTNF receptor superfamily member 1B. (463 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (698 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (815 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (803 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
TNFRSF1ATNF receptor superfamily member 1A. (444 aa)
NFKB1Nuclear factor kappa B subunit 1. (989 aa)
ACACBAcetyl-CoA carboxylase beta. (2447 aa)
RXRGRetinoid X receptor gamma. (463 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (283 aa)
IRS1Insulin receptor substrate 1. (1234 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa)
LOC101100432Uncharacterized protein. (514 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
PRKAA1Non-specific serine/threonine protein kinase. (573 aa)
G6PCGlucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity). Belongs to the glucose-6-phosphatase family. (357 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (607 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
AGRPAgouti related neuropeptide. (132 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (167 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
LEPRLeptin receptor. (1166 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
ACSL6AMP-binding domain-containing protein. (722 aa)
LOC101085801Uncharacterized protein. (467 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
TRADDTNFRSF1A associated via death domain. (311 aa)
IRS2Insulin receptor substrate 2. (1335 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (620 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
NFKBIENFKB inhibitor epsilon. (362 aa)
RXRARetinoid X receptor alpha. (654 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (508 aa)
ACSL5Acyl-CoA synthetase long chain family member 5. (670 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
LOC102900010AMP-binding domain-containing protein. (758 aa)
PPARGC1APPARG coactivator 1 alpha. (803 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (683 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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