STRINGSTRING
ADCY6 ADCY6 MYL6 MYL6 EEF2 EEF2 PRKAB1 PRKAB1 MYLK3 MYLK3 CAMK4 CAMK4 PRKCG PRKCG CACNG7 CACNG7 ITPR1 ITPR1 NPR1 NPR1 HRAS HRAS ADCY3 ADCY3 CACNA1F CACNA1F PIK3R6 PIK3R6 ITPR2 ITPR2 PIK3CG PIK3CG CACNA1S CACNA1S ADCY4 ADCY4 PPP1R12C PPP1R12C CALML6 CALML6 ADCY8 ADCY8 CALML4 CALML4 ACTG1 ACTG1 GNAI2 GNAI2 GNAI1 GNAI1 LOC101083342 LOC101083342 MAPK7 MAPK7 TRPM2 TRPM2 CACNG3 CACNG3 PRKCB PRKCB PPP1CC PPP1CC PRKCA PRKCA NOS3 NOS3 ITPR3 ITPR3 MAP2K2 MAP2K2 CAMK1 CAMK1 MYL6B MYL6B LOC102900772 LOC102900772 KRAS KRAS CALM2 CALM2 PPP1CA PPP1CA RHOA RHOA ADCY9 ADCY9 PRKACA PRKACA CACNG2 CACNG2 PPP1R12A PPP1R12A CACNG8 CACNG8 PTGS2 PTGS2 CDKN1A CDKN1A JUN JUN CACNG5 CACNG5 MAP2K1 MAP2K1 RYR3 RYR3 NFATC3 NFATC3 RGS2 RGS2 OXT OXT PRKAA1 PRKAA1 GNAQ GNAQ PPP3CB PPP3CB KCNJ3 KCNJ3 MAPK1 MAPK1 MYL9 MYL9 PLA2G4D PLA2G4D PLA2G4A PLA2G4A OXTR OXTR CALML3 CALML3 GNAI3 GNAI3 ADCY7 ADCY7 CACNA1C CACNA1C PRKAG3 PRKAG3 LOC101097703 LOC101097703 CACNG4 CACNG4 CACNA2D4 CACNA2D4 KCNJ5 KCNJ5 KCNJ9 KCNJ9 RAF1 RAF1 PRKAG1 PRKAG1 CACNB4 CACNB4 NRAS NRAS PRKAA2 PRKAA2 MAPK3 MAPK3 CACNA2D1 CACNA2D1 PRKAB2 PRKAB2 CNRIP1 CNRIP1 PLCB2 PLCB2 PPP3CA PPP3CA CAMK1G CAMK1G ROCK1 ROCK1 KCNJ14 KCNJ14 PPP1CB PPP1CB GUCY1A1 GUCY1A1 PRKACB PRKACB KCNJ12 KCNJ12 CACNG1 CACNG1 SRC SRC EGFR EGFR CACNB2 CACNB2 PPP3CC PPP3CC PLCB1 PLCB1 GUCY1B1 GUCY1B1 ENSFCAP00000043586 ENSFCAP00000043586 CAMK2B CAMK2B NFATC2 NFATC2 CAMK1D CAMK1D MYLK4 MYLK4 FOS FOS CD38 CD38 CACNG6 CACNG6 NFATC4 NFATC4 KCNJ2 KCNJ2 MAP2K5 MAP2K5 CCND1 CCND1 CACNA1D CACNA1D GUCY1A2 GUCY1A2 GNAS GNAS EEF2K EEF2K NFATC1 NFATC1 RYR2 RYR2 PLA2G4E PLA2G4E PLCB4 PLCB4 ADCY2 ADCY2 PLCB3 PLCB3 ADCY1 ADCY1 NPPA NPPA CAMKK2 CAMKK2 RPS14 RPS14 CACNA2D3 CACNA2D3 ELK1 ELK1 CACNA2D2 CACNA2D2 KCNJ6 KCNJ6 RYR1 RYR1 ROCK2 ROCK2 RCAN1 RCAN1 ADCY5 ADCY5 NPR2 NPR2 KCNJ4 KCNJ4 PIK3R5 PIK3R5 CAMK2D CAMK2D GNAO1 GNAO1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1208 aa)
MYL6Myosin light chain 6. (161 aa)
EEF2Eukaryotic translation elongation factor 2. (858 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
MYLK3Myosin light chain kinase 3. (800 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (638 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
NPR1Guanylate cyclase. (1063 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1984 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (755 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1871 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1010 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit. (773 aa)
CALML6Calmodulin like 6. (180 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
CALML4Calmodulin like 4. (196 aa)
ACTG1Actin gamma 1. (375 aa)
GNAI2G protein subunit alpha i2. (436 aa)
GNAI1G protein subunit alpha i1. (354 aa)
LOC101083342Phospholipase A2. (781 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (804 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1500 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
MAP2K2Protein kinase domain-containing protein. (549 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
MYL6BMyosin light chain 6B. (211 aa)
LOC102900772Uncharacterized protein. (247 aa)
KRASUncharacterized protein. (380 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
RHOARas homolog family member A. (193 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1029 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (422 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (324 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
RYR3Ryanodine receptor 3. (4859 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
OXTOxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (125 aa)
PRKAA1Non-specific serine/threonine protein kinase. (573 aa)
GNAQG protein subunit alpha q. (359 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
MYL9Myosin light chain 9. (172 aa)
PLA2G4DPhospholipase A2. (814 aa)
PLA2G4APhospholipase A2. (749 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (389 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2187 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (607 aa)
LOC101097703EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
CACNA2D4Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1123 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (392 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (519 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
CNRIP1Uncharacterized protein. (324 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (494 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
KCNJ14Potassium voltage-gated channel subfamily J member 14. (432 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (333 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
KCNJ12Uncharacterized protein. (535 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
SRCTyrosine-protein kinase. (678 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (632 aa)
PPP3CCSerine/threonine-protein phosphatase. (523 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (618 aa)
ENSFCAP00000043586Uncharacterized protein. (261 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (748 aa)
NFATC2Nuclear factor of activated T cells 2. (916 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID. (392 aa)
MYLK4Myosin light chain kinase family member 4. (682 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
CD38CD38 molecule. (307 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (262 aa)
NFATC4Nuclear factor of activated T cells 4. (930 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (454 aa)
MAP2K5Uncharacterized protein; Belongs to the protein kinase superfamily. (448 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2216 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (791 aa)
GNASGNAS complex locus. (968 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
NFATC1Nuclear factor of activated T cells 1. (1085 aa)
RYR2Ryanodine receptor 2. (4967 aa)
PLA2G4EPhospholipase A2. (862 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1209 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1135 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa)
NPPAAtrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (204 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (683 aa)
RPS14Calcium/calmodulin dependent protein kinase II alpha. (566 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (1091 aa)
ELK1ETS transcription factor ELK1. (487 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1156 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (451 aa)
RYR1Ryanodine receptor 1. (5041 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1471 aa)
RCAN1Regulator of calcineurin 1. (274 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1329 aa)
NPR2Guanylate cyclase. (1057 aa)
KCNJ4Potassium voltage-gated channel subfamily J member 4. (457 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (904 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (544 aa)
GNAO1G protein subunit alpha o1. (370 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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