STRINGSTRING
SIK1 SIK1 PCK1 PCK1 PRKAB1 PRKAB1 FBP2 FBP2 G6PC3 G6PC3 PDHB PDHB ITPR1 ITPR1 PHKG1 PHKG1 PFKL PFKL AKT3 AKT3 ITPR2 ITPR2 AKT1 AKT1 EP300 EP300 PPARA PPARA CPT1C CPT1C G6PC2 G6PC2 CALML6 CALML6 CREBBP CREBBP CALML4 CALML4 PHKA1 PHKA1 PDHA2 PDHA2 ACACB ACACB PYGB PYGB PHKB PHKB ATF4 ATF4 FBP1 FBP1 PHKG2 PHKG2 PYGM PYGM GYS2 GYS2 PDHA1 PDHA1 ITPR3 ITPR3 PFKM PFKM CREB3L3 CREB3L3 PPP4C PPP4C GCK GCK SIK2 SIK2 LOC102900772 LOC102900772 GCGR GCGR CREB3L1 CREB3L1 CALM2 CALM2 LOC101081229 LOC101081229 PPP4R3A PPP4R3A PRKACA PRKACA PDE3B PDE3B PGAM2 PGAM2 PPP4R3B PPP4R3B ATF2 ATF2 PRKAA1 PRKAA1 GNAQ GNAQ PPP3CB PPP3CB G6PC G6PC SIRT1 SIRT1 CALML3 CALML3 PRKAG3 PRKAG3 PRMT1 PRMT1 CPT1B CPT1B LOC101097703 LOC101097703 PYGL PYGL ENSFCAP00000031759 ENSFCAP00000031759 CREB5 CREB5 PRKAG1 PRKAG1 PRKAA2 PRKAA2 PHKA2 PHKA2 ACACA ACACA PRKAB2 PRKAB2 CNRIP1 CNRIP1 PLCB2 PLCB2 PPP3CA PPP3CA FOXO1 FOXO1 GCG GCG PGAM1 PGAM1 PRKACB PRKACB PPP3CC PPP3CC LDHC LDHC PLCB1 PLCB1 LDHA LDHA ENSFCAP00000043586 ENSFCAP00000043586 PFKFB1 PFKFB1 CAMK2B CAMK2B GYS1 GYS1 PCK2 PCK2 LDHB LDHB SLC2A1 SLC2A1 PFKP PFKP GNAS GNAS CPT1A CPT1A PPARGC1A PPARGC1A PLCB4 PLCB4 ADCY2 ADCY2 PLCB3 PLCB3 CREB3 CREB3 SLC2A2 SLC2A2 RPS14 RPS14 CREB3L2 CREB3L2 AKT2 AKT2 CAMK2D CAMK2D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIK1Uncharacterized protein. (780 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
PHKG1Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (387 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
EP300E1A binding protein p300. (2425 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (803 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
CALML6Calmodulin like 6. (180 aa)
CREBBPCREB binding protein. (2444 aa)
CALML4Calmodulin like 4. (196 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1238 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (391 aa)
ACACBAcetyl-CoA carboxylase beta. (2447 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1093 aa)
ATF4Activating transcription factor 4. (352 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (406 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (702 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (397 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (859 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (448 aa)
PPP4CSerine/threonine-protein phosphatase. (307 aa)
GCKPhosphotransferase. (466 aa)
SIK2Salt inducible kinase 2. (989 aa)
LOC102900772Uncharacterized protein. (247 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (484 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
LOC101081229Pyruvate kinase; Belongs to the pyruvate kinase family. (353 aa)
PPP4R3AProtein phosphatase 4 regulatory subunit 3A. (833 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
PDE3BPhosphodiesterase. (1122 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
PPP4R3BProtein phosphatase 4 regulatory subunit 3B. (820 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
PRKAA1Non-specific serine/threonine protein kinase. (573 aa)
GNAQG protein subunit alpha q. (359 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
G6PCGlucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity). Belongs to the glucose-6-phosphatase family. (357 aa)
SIRT1Sirtuin 1. (745 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (607 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
LOC101097703EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (865 aa)
ENSFCAP00000031759PFK domain-containing protein. (208 aa)
CREB5cAMP responsive element binding protein 5. (523 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1290 aa)
ACACAAcetyl-CoA carboxylase alpha. (2385 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
CNRIP1Uncharacterized protein. (324 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
FOXO1Forkhead box O1. (662 aa)
GCGGlucagon. (203 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (332 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
PPP3CCSerine/threonine-protein phosphatase. (523 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (358 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
ENSFCAP00000043586Uncharacterized protein. (261 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (476 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (748 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (620 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (508 aa)
PFKPUncharacterized protein. (753 aa)
GNASGNAS complex locus. (968 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
PPARGC1APPARG coactivator 1 alpha. (803 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1209 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1135 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
CREB3cAMP responsive element binding protein 3. (399 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (571 aa)
RPS14Calcium/calmodulin dependent protein kinase II alpha. (566 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (536 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (544 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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