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ADCY6 ADCY6 AGTR1 AGTR1 PDE3A PDE3A ITPR1 ITPR1 NPR1 NPR1 REN REN CACNA1F CACNA1F ITPR2 ITPR2 CACNA1S CACNA1S CALML6 CALML6 CALML4 CALML4 GNAI2 GNAI2 GNAI1 GNAI1 PRKG2 PRKG2 ADRB2 ADRB2 ADRB3 ADRB3 ITPR3 ITPR3 EDN2 EDN2 EDN1 EDN1 LOC102900772 LOC102900772 CLCA4 CLCA4 CALM2 CALM2 CLCA1 CLCA1 LOC101093450 LOC101093450 PRKACA PRKACA PDE3B PDE3B AGT AGT ORAI1 ORAI1 GNAQ GNAQ PPP3CB PPP3CB CALML3 CALML3 GNAI3 GNAI3 CACNA1C CACNA1C LOC101097703 LOC101097703 AQP1 AQP1 ADORA1 ADORA1 PDE1C PDE1C PTGER4 PTGER4 ACE ACE CNRIP1 CNRIP1 PLCB2 PLCB2 PPP3CA PPP3CA GUCY1A1 GUCY1A1 PDE1A PDE1A PRKACB PRKACB PDE1B PDE1B EDNRA EDNRA PPP3CC PPP3CC PLCB1 PLCB1 ADRB1 ADRB1 GUCY1B1 GUCY1B1 ENSFCAP00000043586 ENSFCAP00000043586 KCNJ2 KCNJ2 CTSB CTSB CACNA1D CACNA1D GUCY1A2 GUCY1A2 GNAS GNAS PLCB4 PLCB4 PLCB3 PLCB3 NPPA NPPA EDN3 EDN3 ADCY5 ADCY5 CLCA2 CLCA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1208 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (393 aa)
PDE3APhosphodiesterase. (1139 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
NPR1Guanylate cyclase. (1063 aa)
RENRenin; Belongs to the peptidase A1 family. (404 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1984 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1871 aa)
CALML6Calmodulin like 6. (180 aa)
CALML4Calmodulin like 4. (196 aa)
GNAI2G protein subunit alpha i2. (436 aa)
GNAI1G protein subunit alpha i1. (354 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine (By similarity). Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. (418 aa)
ADRB3Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis (By similarity). (398 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
EDN2Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family. (178 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa)
LOC102900772Uncharacterized protein. (247 aa)
CLCA4Chloride channel accessory 4. (916 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
CLCA1Chloride channel accessory 1. (913 aa)
LOC101093450VWFA domain-containing protein. (905 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
PDE3BPhosphodiesterase. (1122 aa)
AGTAngiotensinogen; Belongs to the serpin family. (547 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (406 aa)
GNAQG protein subunit alpha q. (359 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
GNAI3G protein subunit alpha i3. (354 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2187 aa)
LOC101097703EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (310 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
PDE1CPhosphodiesterase. (778 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (489 aa)
ACEAngiotensin-converting enzyme. (1307 aa)
CNRIP1Uncharacterized protein. (324 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
PDE1APhosphodiesterase. (545 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
PDE1BPhosphodiesterase. (535 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
PPP3CCSerine/threonine-protein phosphatase. (523 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ADRB1Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity). (474 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (618 aa)
ENSFCAP00000043586Uncharacterized protein. (261 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (454 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2216 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (791 aa)
GNASGNAS complex locus. (968 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1209 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
NPPAAtrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (204 aa)
EDN3Uncharacterized protein. (318 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1329 aa)
CLCA2Chloride channel accessory 2. (891 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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