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ADCY6 ADCY6 NR4A1 NR4A1 AGTR1 AGTR1 CAMK4 CAMK4 PRKCG PRKCG ITPR1 ITPR1 NPR1 NPR1 ADCY3 ADCY3 POMC POMC CACNA1F CACNA1F ITPR2 ITPR2 CYP21A2 CYP21A2 CACNA1S CACNA1S ADCY4 ADCY4 CALML6 CALML6 ADCY8 ADCY8 CALML4 CALML4 ATP2B1 ATP2B1 ATF4 ATF4 ATP1B1 ATP1B1 PRKD2 PRKD2 CYP11A1 CYP11A1 PRKCB PRKCB DAGLB DAGLB NR4A2 NR4A2 PRKCA PRKCA CACNA1G CACNA1G ATP1A3 ATP1A3 CACNA1I CACNA1I STAR STAR ITPR3 ITPR3 DAGLA DAGLA CREB3L3 CREB3L3 CAMK1 CAMK1 PRKD3 PRKD3 LOC102900772 LOC102900772 ATF6B ATF6B CACNA1H CACNA1H CREB3L1 CREB3L1 CALM2 CALM2 LIPE LIPE ADCY9 ADCY9 PRKACA PRKACA ATP1B3 ATP1B3 MC2R MC2R AGT AGT ATF2 ATF2 ORAI1 ORAI1 GNAQ GNAQ HSD3B2 HSD3B2 BGN BGN PRKD1 PRKD1 CALML3 CALML3 ATP2B2 ATP2B2 ADCY7 ADCY7 CACNA1C CACNA1C LOC101097703 LOC101097703 ATP2B4 ATP2B4 KCNJ5 KCNJ5 SCARB1 SCARB1 ATP1A1 ATP1A1 CREB5 CREB5 PRKCE PRKCE PLCB2 PLCB2 CAMK1G CAMK1G PRKACB PRKACB PLCB1 PLCB1 GNA11 GNA11 ENSFCAP00000043586 ENSFCAP00000043586 CAMK2B CAMK2B CAMK1D CAMK1D KCNK9 KCNK9 ATP1B4 ATP1B4 PDE2A PDE2A KCNK3 KCNK3 ATF1 ATF1 LDLR LDLR CACNA1D CACNA1D GNAS GNAS PLCB4 PLCB4 ADCY2 ADCY2 PLCB3 PLCB3 CREB3 CREB3 ADCY1 ADCY1 NPPA NPPA RPS14 RPS14 CREB3L2 CREB3L2 ATP1A4 ATP1A4 ADCY5 ADCY5 CAMK2D CAMK2D
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1208 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (598 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (393 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (638 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
NPR1Guanylate cyclase. (1063 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
POMCProopiomelanocortin. (258 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1984 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
CYP21A2Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. (494 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1871 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1010 aa)
CALML6Calmodulin like 6. (180 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
CALML4Calmodulin like 4. (196 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
ATF4Activating transcription factor 4. (352 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (885 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
DAGLBDiacylglycerol lipase beta. (692 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2375 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2184 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
DAGLADiacylglycerol lipase alpha. (1044 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (448 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (891 aa)
LOC102900772Uncharacterized protein. (247 aa)
ATF6BActivating transcription factor 6 beta. (628 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2240 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
LIPELipase E, hormone sensitive type. (772 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
MC2RMelanocortin 2 receptor. (297 aa)
AGTAngiotensinogen; Belongs to the serpin family. (547 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
ORAI1ORAI calcium release-activated calcium modulator 1. (406 aa)
GNAQG protein subunit alpha q. (359 aa)
HSD3B23 beta-hydroxysteroid dehydrogenase; Belongs to the 3-beta-HSD family. (373 aa)
BGNCalcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1485 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (930 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2187 aa)
LOC101097703EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1275 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1038 aa)
CREB5cAMP responsive element binding protein 5. (523 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (494 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNA11G protein subunit alpha 11. (359 aa)
ENSFCAP00000043586Uncharacterized protein. (261 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (748 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID. (392 aa)
KCNK9Potassium two pore domain channel subfamily K member 9; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (505 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (357 aa)
PDE2APhosphodiesterase. (942 aa)
KCNK3Potassium channel subfamily K member. (401 aa)
ATF1Activating transcription factor 1. (279 aa)
LDLRLow density lipoprotein receptor. (866 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2216 aa)
GNASGNAS complex locus. (968 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1209 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1135 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
CREB3cAMP responsive element binding protein 3. (399 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa)
NPPAAtrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. (204 aa)
RPS14Calcium/calmodulin dependent protein kinase II alpha. (566 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (536 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1074 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1329 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (544 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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