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LRP6 LRP6 ADCY6 ADCY6 MMP13 MMP13 HBEGF HBEGF SLC34A1 SLC34A1 PRKCG PRKCG GCM2 GCM2 CYP24A1 CYP24A1 ITPR1 ITPR1 MMP15 MMP15 ADCY3 ADCY3 ITPR2 ITPR2 PDE4A PDE4A ADCY4 ADCY4 TNFSF11 TNFSF11 ADCY8 ADCY8 MMP14 MMP14 GNAI2 GNAI2 GNAI1 GNAI1 PLD2 PLD2 ARHGEF1 ARHGEF1 CASR CASR ATF4 ATF4 RXRG RXRG MAFB MAFB PRKCB PRKCB NR4A2 NR4A2 PRKCA PRKCA BRAF BRAF ITPR3 ITPR3 KL KL CREB3L3 CREB3L3 CYP27B1 CYP27B1 LOC102900772 LOC102900772 ATF6B ATF6B CREB3L1 CREB3L1 SP1 SP1 MMP17 MMP17 MMP24 MMP24 MMP16 MMP16 RHOA RHOA ADCY9 ADCY9 PRKACA PRKACA CDKN1A CDKN1A MEF2D MEF2D VDR VDR MAP2K1 MAP2K1 MMP25 MMP25 ATF2 ATF2 GNA13 GNA13 LRP5 LRP5 GNAQ GNAQ SLC34A3 SLC34A3 MAPK1 MAPK1 EGR1 EGR1 GNAI3 GNAI3 ADCY7 ADCY7 PTH1R PTH1R NACA NACA RAF1 RAF1 CREB5 CREB5 FGFR1 FGFR1 SLC34A2 SLC34A2 SLC9A3R1 SLC9A3R1 MAPK3 MAPK3 AKAP13 AKAP13 PLCB2 PLCB2 PLD1 PLD1 GCM1 GCM1 PRKACB PRKACB PTHLH PTHLH EGFR EGFR PLCB1 PLCB1 PTH PTH GNA11 GNA11 ARAF ARAF LOC101085801 LOC101085801 GATA3 GATA3 SOST SOST FOS FOS JUND JUND RUNX2 RUNX2 ARRB1 ARRB1 FGF23 FGF23 GNA12 GNA12 RXRA RXRA PDE4C PDE4C BGLAP BGLAP GNAS GNAS PLCB4 PLCB4 ADCY2 ADCY2 PLCB3 PLCB3 CREB3 CREB3 ADCY1 ADCY1 CREB3L2 CREB3L2 PDE4D PDE4D ADCY5 ADCY5 ARHGEF11 ARHGEF11 PDE4B PDE4B BCL2 BCL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1208 aa)
MMP13Matrix metallopeptidase 13. (470 aa)
HBEGFHeparin binding EGF like growth factor. (305 aa)
SLC34A1Solute carrier family 34 member 1. (639 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
GCM2Glial cells missing transcription factor 2. (505 aa)
CYP24A1Cytochrome P450 family 24 subfamily A member 1. (492 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
MMP15Matrix metallopeptidase 15. (678 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
PDE4APhosphodiesterase. (868 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1010 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
GNAI2G protein subunit alpha i2. (436 aa)
GNAI1G protein subunit alpha i1. (354 aa)
PLD2Phospholipase. (984 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (1069 aa)
CASRCalcium sensing receptor. (1081 aa)
ATF4Activating transcription factor 4. (352 aa)
RXRGRetinoid X receptor gamma. (463 aa)
MAFBMAF bZIP transcription factor B. (323 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
KLKlotho. (1014 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (448 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
LOC102900772Uncharacterized protein. (247 aa)
ATF6BActivating transcription factor 6 beta. (628 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
SP1Sp1 transcription factor. (786 aa)
MMP17Matrix metallopeptidase 17. (643 aa)
MMP24Matrix metallopeptidase 24. (630 aa)
MMP16Matrix metallopeptidase 16. (607 aa)
RHOARas homolog family member A. (193 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
MEF2DMyocyte enhancer factor 2D. (519 aa)
VDRVitamin D receptor. (441 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MMP25ZnMc domain-containing protein. (562 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
GNA13G protein subunit alpha 13. (377 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1620 aa)
GNAQG protein subunit alpha q. (359 aa)
SLC34A3Solute carrier family 34 member 3. (651 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (590 aa)
NACANAC-A/B domain-containing protein. (215 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CREB5cAMP responsive element binding protein 5. (523 aa)
FGFR1Fibroblast growth factor receptor. (852 aa)
SLC34A2Solute carrier family 34 member 2. (724 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
AKAP13Uncharacterized protein. (1431 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
PLD1Phospholipase. (1074 aa)
GCM1Glial cells missing transcription factor 1. (435 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
PTHLHParathyroid hormone like hormone. (222 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). (115 aa)
GNA11G protein subunit alpha 11. (359 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (659 aa)
LOC101085801Uncharacterized protein. (467 aa)
GATA3GATA binding protein 3. (444 aa)
SOSTSclerostin. (212 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (418 aa)
RUNX2RUNX family transcription factor 2. (584 aa)
ARRB1Arrestin beta 1. (421 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
GNA12G protein subunit alpha 12. (382 aa)
RXRARetinoid X receptor alpha. (654 aa)
PDE4CPhosphodiesterase. (732 aa)
BGLAPOsteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (102 aa)
GNASGNAS complex locus. (968 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1209 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1135 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
CREB3cAMP responsive element binding protein 3. (399 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (536 aa)
PDE4DPhosphodiesterase. (809 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1329 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1657 aa)
PDE4BPhosphodiesterase. (737 aa)
BCL2BCL2 apoptosis regulator. (237 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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