STRINGSTRING
MTOR MTOR PCK1 PCK1 PRKAB1 PRKAB1 PDPK1 PDPK1 SREBF1 SREBF1 STAT3 STAT3 G6PC3 G6PC3 MAPK10 MAPK10 SLC27A3 SLC27A3 SLC2A4 SLC2A4 AKT3 AKT3 SLC27A5 SLC27A5 PRKCD PRKCD PTPN1 PTPN1 MLXIPL MLXIPL AKT1 AKT1 PPARA PPARA G6PC2 G6PC2 NFKBIA NFKBIA TNFRSF1A TNFRSF1A NFKB1 NFKB1 ACACB ACACB PYGB PYGB RPS6KA6 RPS6KA6 SLC27A6 SLC27A6 NR1H2 NR1H2 PPP1R3C PPP1R3C SLC27A2 SLC27A2 PIK3R1 PIK3R1 PRKCB PRKCB PPP1CC PPP1CC MLXIP MLXIP PYGM PYGM GYS2 GYS2 NOS3 NOS3 CREB3L3 CREB3L3 TBC1D4 TBC1D4 CREB3L1 CREB3L1 PTEN PTEN PPP1R3A PPP1R3A PPP1CA PPP1CA IRS1 IRS1 SOCS3 SOCS3 PPP1R3D PPP1R3D RPS6KB1 RPS6KB1 AGT AGT PIK3CD PIK3CD PRKAA1 PRKAA1 G6PC G6PC OGA OGA PIK3CB PIK3CB PRKAG3 PRKAG3 CPT1B CPT1B RPS6KA3 RPS6KA3 PTPN11 PTPN11 OGT OGT CD36 CD36 INSR INSR PYGL PYGL CREB5 CREB5 PRKAG1 PRKAG1 PRKAA2 PRKAA2 RPS6KA1 RPS6KA1 PRKCE PRKCE PRKAB2 PRKAB2 TRIB3 TRIB3 PIK3CA PIK3CA PPP1CB PPP1CB MAPK8 MAPK8 FOXO1 FOXO1 PRKCQ PRKCQ PPP1R3E PPP1R3E RPS6KA2 RPS6KA2 PIK3R2 PIK3R2 GSK3B GSK3B IKBKB IKBKB PPP1R3B PPP1R3B GYS1 GYS1 PTPA PTPA PIK3R3 PIK3R3 IRS2 IRS2 PCK2 PCK2 MLX MLX MAPK9 MAPK9 RELA RELA TNF TNF SLC2A1 SLC2A1 NR1H3 NR1H3 SLC27A1 SLC27A1 CPT1A CPT1A PPARGC1A PPARGC1A PPARGC1B PPARGC1B RPS6KB2 RPS6KB2 PRKCZ PRKCZ CREB3 CREB3 SLC2A2 SLC2A2 GFPT1 GFPT1 GFPT2 GFPT2 CREB3L2 CREB3L2 AKT2 AKT2 PTPRF PTPRF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1147 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
SLC27A3Solute carrier family 27 member 3. (816 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (585 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SLC27A5Solute carrier family 27 member 5. (687 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (427 aa)
MLXIPLMLX interacting protein like. (857 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
TNFRSF1ATNF receptor superfamily member 1A. (444 aa)
NFKB1Nuclear factor kappa B subunit 1. (989 aa)
ACACBAcetyl-CoA carboxylase beta. (2447 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
RPS6KA6Ribosomal protein S6 kinase. (744 aa)
SLC27A6Solute carrier family 27 member 6. (619 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (457 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
SLC27A2Solute carrier family 27 member 2. (620 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
MLXIPMLX interacting protein. (916 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (702 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (448 aa)
TBC1D4TBC1 domain family member 4. (1297 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1122 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
IRS1Insulin receptor substrate 1. (1234 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (297 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
AGTAngiotensinogen; Belongs to the serpin family. (547 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PRKAA1Non-specific serine/threonine protein kinase. (573 aa)
G6PCGlucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity). Belongs to the glucose-6-phosphatase family. (357 aa)
OGAO-GlcNAcase. (915 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (607 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (865 aa)
CREB5cAMP responsive element binding protein 5. (523 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
TRIB3Tribbles pseudokinase 3. (357 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (333 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
FOXO1Forkhead box O1. (662 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
RPS6KA2Ribosomal protein S6 kinase. (741 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
GSK3BProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (304 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (737 aa)
PTPASerine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (329 aa)
PIK3R3Uncharacterized protein. (461 aa)
IRS2Insulin receptor substrate 2. (1335 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (620 aa)
MLXMAX dimerization protein MLX. (288 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (508 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (498 aa)
SLC27A1Solute carrier family 27 member 1. (796 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
PPARGC1APPARG coactivator 1 alpha. (803 aa)
PPARGC1BPPARG coactivator 1 beta. (1006 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
PRKCZProtein kinase C zeta. (649 aa)
CREB3cAMP responsive element binding protein 3. (399 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (571 aa)
GFPT1Glutamine--fructose-6-phosphate transaminase 1. (699 aa)
GFPT2Glutamine-fructose-6-phosphate transaminase 2. (682 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (536 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (2147 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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