STRINGSTRING
BAX BAX AGTR1 AGTR1 CCL2 CCL2 STAT5B STAT5B STAT3 STAT3 MAPK10 MAPK10 HRAS HRAS CYBB CYBB AKT3 AKT3 PRKCD PRKCD PLCD4 PLCD4 AGER AGER COL1A1 COL1A1 CXCL8 CXCL8 AKT1 AKT1 TGFB1 TGFB1 PLCD3 PLCD3 SERPINE1 SERPINE1 IL1B IL1B PLCE1 PLCE1 NOX1 NOX1 NFKB1 NFKB1 VEGFC VEGFC IL1A IL1A FN1 FN1 ICAM1 ICAM1 PIK3R1 PIK3R1 VCAM1 VCAM1 PRKCB PRKCB THBD THBD MAPK11 MAPK11 PRKCA PRKCA F3 F3 NOS3 NOS3 TGFB3 TGFB3 COL3A1 COL3A1 COL4A1 COL4A1 EDN1 EDN1 KRAS KRAS CDK4 CDK4 COL1A2 COL1A2 JUN JUN PIM1 PIM1 AGT AGT PIK3CD PIK3CD MAPK14 MAPK14 CDC42-2 CDC42-2 NOX4 NOX4 MAPK1 MAPK1 PIK3CB PIK3CB EGR1 EGR1 MAPK12 MAPK12 SMAD4 SMAD4 CASP3 CASP3 NRAS NRAS MAPK3 MAPK3 PRKCE PRKCE PLCB2 PLCB2 PIK3CA PIK3CA MAPK8 MAPK8 FOXO1 FOXO1 MMP2 MMP2 SELE SELE PLCB1 PLCB1 PLCG2 PLCG2 COL4A3 COL4A3 PIK3R2 PIK3R2 COL4A6 COL4A6 CDKN1B CDKN1B PIK3R3 PIK3R3 COL4A5 COL4A5 MAPK9 MAPK9 TGFBR1 TGFBR1 RELA RELA JAK2 JAK2 STAT1 STAT1 TNF TNF CCND1 CCND1 COL4A2 COL4A2 PLCD1 PLCD1 NFATC1 NFATC1 PRKCZ PRKCZ PLCG1 PLCG1 STAT5A STAT5A PLCB4 PLCB4 PLCB3 PLCB3 SMAD2 SMAD2 AKT2 AKT2 DIAPH1 DIAPH1 BCL2 BCL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BAXBCL2 associated X, apoptosis regulator. (192 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (393 aa)
CCL2C-C motif chemokine. (99 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
PLCD4Phosphoinositide phospholipase C. (800 aa)
AGERAdvanced glycosylation end-product specific receptor. (492 aa)
COL1A1Collagen type I alpha 1 chain. (1461 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PLCD3Phosphoinositide phospholipase C. (777 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
PLCE1Phosphoinositide phospholipase C. (2301 aa)
NOX1NADPH oxidase 1. (564 aa)
NFKB1Nuclear factor kappa B subunit 1. (989 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
FN1Fibronectin 1. (2475 aa)
ICAM1Intercellular adhesion molecule 1. (532 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
VCAM1Vascular cell adhesion molecule 1. (748 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
THBDThrombomodulin. (672 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
F3Coagulation factor III, tissue factor. (379 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa)
KRASUncharacterized protein. (380 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
COL1A2Collagen type I alpha 2 chain. (1367 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
PIM1Serine/threonine-protein kinase pim-1; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly th [...] (313 aa)
AGTAngiotensinogen; Belongs to the serpin family. (547 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CDC42-2Uncharacterized protein. (191 aa)
NOX4NADPH oxidase 4. (578 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
FOXO1Forkhead box O1. (662 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
SELESelectin E. (638 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1318 aa)
COL4A3Collagen type IV alpha 3 chain. (1669 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa)
PIK3R3Uncharacterized protein. (461 aa)
COL4A5Collagen type IV alpha 5 chain. (1689 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
STAT1Signal transducer and activator of transcription. (885 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
COL4A2Collagen type IV alpha 2 chain. (1854 aa)
PLCD1Phosphoinositide phospholipase C. (801 aa)
NFATC1Nuclear factor of activated T cells 1. (1085 aa)
PRKCZProtein kinase C zeta. (649 aa)
PLCG1Phosphoinositide phospholipase C. (1391 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1209 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
SMAD2Mothers against decapentaplegic homolog. (721 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
DIAPH1Diaphanous related formin 1. (1290 aa)
BCL2BCL2 apoptosis regulator. (237 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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