STRINGSTRING
MTOR MTOR ATP5F1C ATP5F1C BAX BAX TRAF2 TRAF2 PSMD6 PSMD6 TUBAL3 TUBAL3 PSMC2 PSMC2 DNAH6 DNAH6 PSMD8 PSMD8 PSMC4 PSMC4 ACTR1A ACTR1A NDUFA2 NDUFA2 COX5B COX5B NDUFV1 NDUFV1 PSMB4 PSMB4 POLR2K POLR2K UQCRC1 UQCRC1 MAPK10 MAPK10 ITPR1 ITPR1 LOC101086703 LOC101086703 PSMD13 PSMD13 NDUFS8 NDUFS8 DNAI1 DNAI1 PSMC5 PSMC5 ERN1 ERN1 NDUFA3 NDUFA3 TUBB4B TUBB4B LOC101090556 LOC101090556 KLC2 KLC2 AP2A1 AP2A1 HTT HTT EP300 EP300 ULK2 ULK2 SLC1A3 SLC1A3 CREBBP CREBBP TUBB1 TUBB1 ATG2B ATG2B TBP TBP SLC25A5 SLC25A5 SLC25A31 SLC25A31 POLR2E POLR2E UQCRC2 UQCRC2 PSMD2 PSMD2 POLR2H POLR2H MAP3K5 MAP3K5 DNALI1 DNALI1 UCP1 UCP1 DNAH2 DNAH2 KLC4 KLC4 RB1CC1 RB1CC1 RCOR1 RCOR1 LOC101099268 LOC101099268 ULK1 ULK1 DNAH10 DNAH10 SIN3A SIN3A PSMA1 PSMA1 CYC1 CYC1 TAF4B TAF4B NDUFB10 NDUFB10 TUBA1C TUBA1C DNAH9 DNAH9 ATP5F1B ATP5F1B MAP3K10 MAP3K10 ATG2A ATG2A ATP5MC3 ATP5MC3 BECN1 BECN1 NDUFAB1 NDUFAB1 NDUFB7 NDUFB7 AMBRA1 AMBRA1 ATG13 ATG13 CREB3L3 CREB3L3 COX7A1 COX7A1 NDUFA13 NDUFA13 PSMB7 PSMB7 COX8A COX8A COX4I2 COX4I2 NDUFA7 NDUFA7 DNAH5 DNAH5 DNAH1 DNAH1 NDUFA11 NDUFA11 CREB3L1 CREB3L1 SP1 SP1 PSMD9 PSMD9 NDUFA6 NDUFA6 NDUFA12 NDUFA12 GPX5 GPX5 ATG14 ATG14 ATP5PO ATP5PO IFT57 IFT57 PSMD7 PSMD7 KIF5B KIF5B ATP5PB ATP5PB POLR2D POLR2D CASP9 CASP9 PSMA6 PSMA6 NDUFS1 NDUFS1 DCTN4 DCTN4 NDUFB11 NDUFB11 CLTCL1 CLTCL1 ATP5F1A ATP5F1A UQCRQ UQCRQ NDUFS7 NDUFS7 VDAC2 VDAC2 PSMD12 PSMD12 NDUFB3 NDUFB3 GPX8 GPX8 UQCRFS1 UQCRFS1 CLTC CLTC DNAH14 DNAH14 POLR2G POLR2G LOC101100947 LOC101100947 TUBB TUBB NDUFS5 NDUFS5 POLR2I POLR2I PSMD11 PSMD11 PSMA2 PSMA2 SDHD SDHD LOC101080736 LOC101080736 DNAL1 DNAL1 GNAQ GNAQ M3XDY9_FELCA M3XDY9_FELCA PSMA8 PSMA8 PPIF PPIF PIK3C3 PIK3C3 ND2 ND2 COX1 COX1 COX2 COX2 ATP8 ATP8 ATP6 ATP6 COX3 COX3 ND3 ND3 ND4L ND4L ND4 ND4 ND5 ND5 ND6 ND6 CYTB CYTB ND1 ND1 PSMB6 PSMB6 SOD2 SOD2 POLR2J POLR2J AP2A2 AP2A2 KIF5C KIF5C SDHC SDHC NDUFS6 NDUFS6 TFAM TFAM NDUFS2 NDUFS2 LOC102899183 LOC102899183 TUBB6 TUBB6 LOC101100266 LOC101100266 NDUFB2 NDUFB2 CASP3 CASP3 LOC101096876 LOC101096876 GPX1 GPX1 COX7B COX7B CREB5 CREB5 KIF5A KIF5A HDAC1 HDAC1 DCTN5 DCTN5 NDUFB1 NDUFB1 KLC1 KLC1 PSMA5 PSMA5 SOD1 SOD1 ENSFCAP00000034800 ENSFCAP00000034800 NDUFB5 NDUFB5 SLC25A4 SLC25A4 HDAC2 HDAC2 GRIA1 GRIA1 GRIA2 GRIA2 TBPL1 TBPL1 NDUFA1 NDUFA1 NDUFA5 NDUFA5 PSMC1 PSMC1 PLCB2 PLCB2 ATG101 ATG101 DLG4 DLG4 POLR2C POLR2C DCTN1 DCTN1 COX7B2 COX7B2 VDAC1 VDAC1 TUBA4A TUBA4A DCTN6 DCTN6 NDUFA4 NDUFA4 ENSFCAP00000038072 ENSFCAP00000038072 MAPK8 MAPK8 CHRNB1 CHRNB1 GPX2 GPX2 GPX3 GPX3 SEM1 SEM1 SDHA SDHA PIK3R4 PIK3R4 ATP5PF ATP5PF REST REST PLCB1 PLCB1 ACTR10 ACTR10 NDUFB8 NDUFB8 STX1A STX1A AP2B1 AP2B1 PSMC3 PSMC3 LOC105261211 LOC105261211 LOC101095773 LOC101095773 DNAL4 DNAL4 TUBA8 TUBA8 PSMD14 PSMD14 GRIN2B GRIN2B DNAH12 DNAH12 NRF1 NRF1 NDUFB9 NDUFB9 GRM5 GRM5 BBC3 BBC3 MAP2K7 MAP2K7 KCNJ10 KCNJ10 DCTN2 DCTN2 APAF1 APAF1 POLR2F POLR2F MAPK9 MAPK9 DNAH7 DNAH7 ENSFCAP00000047742 ENSFCAP00000047742 PSMA4 PSMA4 SLC25A6 SLC25A6 PSMD4 PSMD4 PSMB5 PSMB5 NDUFS3 NDUFS3 NDUFV3 NDUFV3 GRIA3 GRIA3 POLR2B POLR2B BDNF BDNF POLR2L POLR2L COX4I1 COX4I1 HIP1 HIP1 LOC101095032 LOC101095032 PSMD1 PSMD1 PPARG PPARG NDUFA4L2 NDUFA4L2 SLC1A2 SLC1A2 ATP5F1D ATP5F1D AP2S1 AP2S1 PSMB1 PSMB1 NDUFA9 NDUFA9 NDUFB4 NDUFB4 CACNA1B CACNA1B DNAH3 DNAH3 PSMA3 PSMA3 GPX6 GPX6 PPARGC1A PPARGC1A DNAH17 DNAH17 NDUFS4 NDUFS4 DNAH8 DNAH8 CASP8 CASP8 PLCB4 PLCB4 PLCB3 PLCB3 CREB3 CREB3 GRIN1 GRIN1 TGM2 TGM2 TAF4 TAF4 VDAC3 VDAC3 NRBF2 NRBF2 GRIA4 GRIA4 KLC3 KLC3 PSMB2 PSMB2 WIPI1 WIPI1 ATP5MC1 ATP5MC1 PSMC6 PSMC6 PSMB3 PSMB3 CREB3L2 CREB3L2 SDHB SDHB NDUFA8 NDUFA8 UQCRB UQCRB NDUFV2 NDUFV2 PSMD3 PSMD3 LOC101081808 LOC101081808 DNAH11 DNAH11 UQCR10 UQCR10 NDUFA10 NDUFA10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
ATP5F1CATP synthase subunit gamma. (298 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (478 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
DNAH6Dynein axonemal heavy chain 6. (4155 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (355 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
ACTR1AActin related protein 1A. (376 aa)
NDUFA2NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (99 aa)
COX5BCytochrome c oxidase subunit 5B. (129 aa)
NDUFV1NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (464 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
POLR2KUncharacterized protein. (58 aa)
UQCRC1Ubiquinol-cytochrome c reductase core protein 1. (481 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa)
LOC101086703Uncharacterized protein. (56 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (376 aa)
NDUFS8NADH:ubiquinone oxidoreductase core subunit S8. (210 aa)
DNAI1Dynein axonemal intermediate chain 1. (719 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (972 aa)
NDUFA3Uncharacterized protein. (84 aa)
TUBB4BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
LOC101090556Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
KLC2Kinesin light chain 2. (622 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (978 aa)
HTTHuntingtin. (3140 aa)
EP300E1A binding protein p300. (2425 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1039 aa)
SLC1A3Amino acid transporter. (542 aa)
CREBBPCREB binding protein. (2444 aa)
TUBB1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (457 aa)
ATG2BAutophagy related 2B. (2114 aa)
TBPTATA-box binding protein. (327 aa)
SLC25A5Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
SLC25A31Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
POLR2ERNA polymerase II subunit E. (210 aa)
UQCRC2Ubiquinol-cytochrome c reductase core protein 2; Belongs to the peptidase M16 family. (453 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1366 aa)
DNALI1Dynein axonemal light intermediate chain 1. (278 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
DNAH2Dynein axonemal heavy chain 2. (4358 aa)
KLC4Kinesin light chain 4. (615 aa)
RB1CC1RB1 inducible coiled-coil 1. (1593 aa)
RCOR1REST corepressor 1. (486 aa)
LOC101099268Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (515 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1113 aa)
DNAH10Dynein axonemal heavy chain 10. (4501 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
PSMA1Proteasome subunit alpha type. (263 aa)
CYC1Cytochrome c1. (325 aa)
TAF4BTATA-box binding protein associated factor 4b. (869 aa)
NDUFB10NADH:ubiquinone oxidoreductase subunit B10. (170 aa)
TUBA1CTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (518 aa)
DNAH9Uncharacterized protein. (798 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (937 aa)
ATG2AAutophagy related 2A. (1928 aa)
ATP5MC3ATP synthase membrane subunit c locus 3; Belongs to the ATPase C chain family. (178 aa)
BECN1Beclin 1. (448 aa)
NDUFAB1Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (154 aa)
NDUFB7NADH:ubiquinone oxidoreductase subunit B7. (137 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1301 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (448 aa)
COX7A1Cytochrome c oxidase subunit 7A1. (80 aa)
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (144 aa)
PSMB7Proteasome subunit beta. (277 aa)
COX8ACytochrome c oxidase subunit 8A. (69 aa)
COX4I2Cytochrome c oxidase subunit 4I2. (182 aa)
NDUFA7Uncharacterized protein. (113 aa)
DNAH5Dynein axonemal heavy chain 5. (4623 aa)
DNAH1Dynein axonemal heavy chain 1. (4266 aa)
NDUFA11Uncharacterized protein. (141 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
SP1Sp1 transcription factor. (786 aa)
PSMD9Proteasome 26S subunit, non-ATPase 9. (284 aa)
NDUFA6NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (128 aa)
NDUFA12NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (145 aa)
GPX5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (222 aa)
ATG14Autophagy related 14. (510 aa)
ATP5POUncharacterized protein. (213 aa)
IFT57Intraflagellar transport 57. (429 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (963 aa)
ATP5PBATP synthase peripheral stalk-membrane subunit b. (251 aa)
POLR2DRNA polymerase II subunit D. (142 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (451 aa)
PSMA6Proteasome subunit alpha type. (251 aa)
NDUFS1NADH:ubiquinone oxidoreductase core subunit S1. (691 aa)
DCTN4Dynactin subunit 4. (550 aa)
NDUFB11NADH:ubiquinone oxidoreductase subunit B11. (241 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1673 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
UQCRQUbiquinol-cytochrome c reductase complex III subunit VII. (82 aa)
NDUFS7NADH:ubiquinone oxidoreductase core subunit S7; Belongs to the complex I 20 kDa subunit family. (306 aa)
VDAC2Voltage dependent anion channel 2. (294 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
NDUFB3NADH:ubiquinone oxidoreductase subunit B3. (98 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
UQCRFS1Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (274 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1679 aa)
DNAH14Uncharacterized protein. (4490 aa)
POLR2GRNA polymerase II subunit G. (172 aa)
LOC101100947Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TUBBTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
NDUFS5NADH:ubiquinone oxidoreductase subunit S5. (178 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
SDHDSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
LOC101080736NADH dehydrogenase [ubiquinone] 1 subunit C2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (120 aa)
DNAL1Dynein axonemal light chain 1. (190 aa)
GNAQG protein subunit alpha q. (359 aa)
M3XDY9_FELCAUncharacterized protein. (92 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (204 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
ND2NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (347 aa)
COX1Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (514 aa)
COX2Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (227 aa)
ATP8ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (67 aa)
ATP6ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (226 aa)
COX3Cytochrome c oxidase subunit 3; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (261 aa)
ND3NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (115 aa)
ND4LNADH-ubiquinone oxidoreductase chain 4L; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (98 aa)
ND4NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (459 aa)
ND5NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (606 aa)
ND6NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (175 aa)
CYTBCytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (379 aa)
ND1NADH-ubiquinone oxidoreductase chain 1; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (318 aa)
PSMB6Proteasome subunit beta. (239 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
POLR2JRNA polymerase II subunit J. (117 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (976 aa)
KIF5CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (957 aa)
SDHCSuccinate dehydrogenase complex subunit C. (184 aa)
NDUFS6NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (125 aa)
TFAMTranscription factor A, mitochondrial. (246 aa)
NDUFS2NADH:ubiquinone oxidoreductase core subunit S2; Belongs to the complex I 49 kDa subunit family. (489 aa)
LOC102899183Uncharacterized protein. (63 aa)
TUBB6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
LOC101100266Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (86 aa)
NDUFB2NADH:ubiquinone oxidoreductase subunit B2. (105 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
LOC101096876COX6C domain-containing protein. (75 aa)
GPX1Glutathione peroxidase; Belongs to the glutathione peroxidase family. (205 aa)
COX7BCytochrome c oxidase subunit 7B. (80 aa)
CREB5cAMP responsive element binding protein 5. (523 aa)
KIF5AKinesin family member 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1039 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (498 aa)
DCTN5Dynactin subunit 5. (182 aa)
NDUFB1Uncharacterized protein. (104 aa)
KLC1Uncharacterized protein. (628 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (155 aa)
ENSFCAP00000034800Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (93 aa)
NDUFB5NADH:ubiquinone oxidoreductase subunit B5. (242 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
HDAC2Histone deacetylase 2. (602 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
TBPL1TATA-box binding protein like 1. (186 aa)
NDUFA1Uncharacterized protein. (70 aa)
NDUFA5NADH:ubiquinone oxidoreductase subunit A5. (117 aa)
PSMC1AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
ATG101Autophagy related 101. (344 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (797 aa)
POLR2CRNA polymerase II subunit C. (275 aa)
DCTN1CAP-Gly domain-containing protein. (1279 aa)
COX7B2Cytochrome c oxidase subunit 7B2. (79 aa)
VDAC1Voltage dependent anion channel 1. (283 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
DCTN6Dynactin subunit 6. (190 aa)
NDUFA4Uncharacterized protein. (82 aa)
ENSFCAP00000038072Uncharacterized protein. (92 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CHRNB1DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the ligand-gated ion channel (TC 1.A.9) family. (2274 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (189 aa)
GPX3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
SEM1Uncharacterized protein. (70 aa)
SDHASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (665 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
ATP5PFATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain; Belongs to the eukaryotic ATPase subunit F6 family. (116 aa)
RESTRE1 silencing transcription factor. (1045 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
ACTR10Actin related protein 10; Belongs to the actin family. (417 aa)
NDUFB8NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (186 aa)
STX1ASyntaxin 1A. (334 aa)
AP2B1AP complex subunit beta. (951 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa)
LOC105261211Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (88 aa)
LOC101095773Cytochrome c oxidase subunit 6A, mitochondrial. (109 aa)
DNAL4Dynein light chain. (105 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (481 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1486 aa)
DNAH12Uncharacterized protein. (3945 aa)
NRF1Nuclear respiratory factor 1. (556 aa)
NDUFB9NADH:ubiquinone oxidoreductase subunit B9; Belongs to the complex I LYR family. (179 aa)
GRM5Glutamate metabotropic receptor 5. (1208 aa)
BBC3Uncharacterized protein. (193 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
KCNJ10Potassium voltage-gated channel subfamily J member 10. (563 aa)
DCTN2Dynactin subunit 2. (408 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa)
POLR2FRNA polymerase II subunit F. (127 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
DNAH7Dynein axonemal heavy chain 7. (4023 aa)
ENSFCAP00000047742Uncharacterized protein. (97 aa)
PSMA4Proteasome subunit alpha type. (277 aa)
SLC25A6Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (318 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (423 aa)
PSMB5Proteasome subunit beta. (263 aa)
NDUFS3NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family. (265 aa)
NDUFV3Uncharacterized protein. (107 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (255 aa)
POLR2LRNA polymerase II subunit L. (67 aa)
COX4I1Cytochrome c oxidase subunit 4I1. (201 aa)
HIP1Huntingtin interacting protein 1. (1036 aa)
LOC101095032Cytochrome b-c1 complex subunit 6; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. Belongs to the UQCRH/QCR6 family. (91 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
NDUFA4L2NDUFA4 mitochondrial complex associated like 2. (91 aa)
SLC1A2Amino acid transporter. (579 aa)
ATP5F1DATP-synt_DE_N domain-containing protein. (282 aa)
AP2S1Adaptor related protein complex 2 subunit sigma 1. (220 aa)
PSMB1Proteasome subunit beta. (261 aa)
NDUFA9NADH:ubiquinone oxidoreductase subunit A9. (389 aa)
NDUFB4NADH:ubiquinone oxidoreductase subunit B4. (132 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2202 aa)
DNAH3Dynein axonemal heavy chain 3. (4068 aa)
PSMA3Proteasome subunit alpha type. (258 aa)
GPX6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (221 aa)
PPARGC1APPARG coactivator 1 alpha. (803 aa)
DNAH17Uncharacterized protein. (799 aa)
NDUFS4NADH:ubiquinone oxidoreductase subunit S4. (187 aa)
DNAH8Dynein axonemal heavy chain 8. (4631 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (479 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1209 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
CREB3cAMP responsive element binding protein 3. (399 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (1008 aa)
TGM2Transglutaminase 2. (733 aa)
TAF4TATA-box binding protein associated factor 4. (1099 aa)
VDAC3Voltage dependent anion channel 3. (315 aa)
NRBF2Nuclear receptor binding factor 2. (288 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (901 aa)
KLC3Kinesin light chain 3. (637 aa)
PSMB2Proteasome subunit beta. (201 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (470 aa)
ATP5MC1ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (142 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (477 aa)
PSMB3Proteasome subunit beta. (268 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (536 aa)
SDHBSuccinate dehydrogenase complex iron sulfur subunit B. (307 aa)
NDUFA8NADH:ubiquinone oxidoreductase subunit A8. (331 aa)
UQCRBUbiquinol-cytochrome c reductase binding protein. (137 aa)
NDUFV2NADH:ubiquinone oxidoreductase core subunit V2. (256 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (595 aa)
LOC101081808Uncharacterized protein. (154 aa)
DNAH11Dynein axonemal heavy chain 11. (4245 aa)
UQCR10Ubiquinol-cytochrome c reductase, complex III subunit X. (182 aa)
NDUFA10NADH:ubiquinone oxidoreductase subunit A10. (442 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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