STRINGSTRING
CAMK4 CAMK4 PRKCG PRKCG CALML6 CALML6 CALML4 CALML4 ATF4 ATF4 PRKCB PRKCB PPP1CC PPP1CC SLC18A1 SLC18A1 PRKCA PRKCA SLC18A2 SLC18A2 MAOB MAOB CREB3L3 CREB3L3 GRIN2A GRIN2A LOC102900772 LOC102900772 ATF6B ATF6B GRIN3A GRIN3A CREB3L1 CREB3L1 GRIN2D GRIN2D CALM2 CALM2 PPP1CA PPP1CA PRKACA PRKACA JUN JUN FOSB FOSB ATF2 ATF2 PPP3CB PPP3CB SIRT1 SIRT1 CALML3 CALML3 CACNA1C CACNA1C PDYN PDYN LOC101097703 LOC101097703 CREB5 CREB5 HDAC1 HDAC1 ARC ARC HDAC2 HDAC2 GRIA1 GRIA1 GRIA2 GRIA2 CNRIP1 CNRIP1 PPP3CA PPP3CA PPP1CB PPP1CB TH TH PRKACB PRKACB PPP3CC PPP3CC STX1A STX1A ENSFCAP00000043586 ENSFCAP00000043586 CAMK2B CAMK2B GRIN2B GRIN2B FOS FOS MAOA MAOA DDC DDC GRIA3 GRIA3 DRD1 DRD1 CACNA1D CACNA1D GNAS GNAS CREB3 CREB3 GRIN1 GRIN1 RPS14 RPS14 PPP1R1B PPP1R1B GRIN2C GRIN2C GRIA4 GRIA4 CREB3L2 CREB3L2 ADCY5 ADCY5 CAMK2D CAMK2D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CAMK4Calcium/calmodulin dependent protein kinase IV. (638 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
CALML6Calmodulin like 6. (180 aa)
CALML4Calmodulin like 4. (196 aa)
ATF4Activating transcription factor 4. (352 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
SLC18A1Solute carrier family 18 member A1. (519 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
SLC18A2Solute carrier family 18 member A2. (517 aa)
MAOBAmine oxidase. (520 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (448 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
LOC102900772Uncharacterized protein. (247 aa)
ATF6BActivating transcription factor 6 beta. (628 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1116 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1338 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
SIRT1Sirtuin 1. (745 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2187 aa)
PDYNProdynorphin. (255 aa)
LOC101097703EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa)
CREB5cAMP responsive element binding protein 5. (523 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (498 aa)
ARCActivity regulated cytoskeleton associated protein. (396 aa)
HDAC2Histone deacetylase 2. (602 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
CNRIP1Uncharacterized protein. (324 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (333 aa)
THInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (557 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
PPP3CCSerine/threonine-protein phosphatase. (523 aa)
STX1ASyntaxin 1A. (334 aa)
ENSFCAP00000043586Uncharacterized protein. (261 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (748 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1486 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
MAOAAmine oxidase. (1178 aa)
DDCDopa decarboxylase. (480 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (463 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2216 aa)
GNASGNAS complex locus. (968 aa)
CREB3cAMP responsive element binding protein 3. (399 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (1008 aa)
RPS14Calcium/calmodulin dependent protein kinase II alpha. (566 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (209 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1325 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (901 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (536 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1329 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (544 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.