STRINGSTRING
CAMK4 CAMK4 CRH CRH HAT1 HAT1 HRAS HRAS SHC3 SHC3 CALML6 CALML6 CALML4 CALML4 HDAC3 HDAC3 GNAI2 GNAI2 GNAI1 GNAI1 NTRK2 NTRK2 ATF4 ATF4 H2BC18 H2BC18 GNG13 GNG13 PPP1CC PPP1CC SLC18A1 SLC18A1 GNB3 GNB3 BRAF BRAF SLC18A2 SLC18A2 MAOB MAOB MACROH2A1 MACROH2A1 CREB3L3 CREB3L3 GRIN2A GRIN2A H2BC1 H2BC1 SHC2 SHC2 LOC102900772 LOC102900772 ATF6B ATF6B GRIN3A GRIN3A SLC29A2 SLC29A2 CREB3L1 CREB3L1 GRIN2D GRIN2D KRAS KRAS CALM2 CALM2 PPP1CA PPP1CA GNB1 GNB1 LOC101083005 LOC101083005 GNGT1 GNGT1 PRKACA PRKACA M3WZ36_FELCA M3WZ36_FELCA LOC101096314 LOC101096314 H3F3A H3F3A H2BU1 H2BU1 H2AJ H2AJ LOC101088423 LOC101088423 FOSB FOSB GNB2 GNB2 GNG14 GNG14 LOC101092488 LOC101092488 MAP2K1 MAP2K1 ADORA2A ADORA2A SOS1 SOS1 ATF2 ATF2 LOC101097798 LOC101097798 H2AW H2AW H2AC6 H2AC6 GRB2 GRB2 H2AC1 H2AC1 SOS2 SOS2 MAPK1 MAPK1 M3XGB0_FELCA M3XGB0_FELCA LOC101087401 LOC101087401 GNB4 GNB4 GNG11 GNG11 GNGT2 GNGT2 CALML3 CALML3 GNAI3 GNAI3 PDYN PDYN LOC101097703 LOC101097703 ENSFCAP00000028809 ENSFCAP00000028809 PKIA PKIA SHC4 SHC4 HDAC11 HDAC11 RAF1 RAF1 CREB5 CREB5 HDAC1 HDAC1 GNG3 GNG3 NRAS NRAS MAPK3 MAPK3 HDAC2 HDAC2 HDAC9 HDAC9 LOC101093519 LOC101093519 HDAC4 HDAC4 PPP1CB PPP1CB GNG5 GNG5 TH TH PRKACB PRKACB LOC101082235 LOC101082235 HIST2H3C HIST2H3C LOC105260541 LOC105260541 ARAF ARAF ENSFCAP00000042498 ENSFCAP00000042498 ENSFCAP00000043372 ENSFCAP00000043372 MACROH2A2 MACROH2A2 ENSFCAP00000043586 ENSFCAP00000043586 GRIN2B GRIN2B HDAC6 HDAC6 HDAC7 HDAC7 LOC101088237 LOC101088237 MAOA MAOA GNG12 GNG12 GNG8 GNG8 LOC101083265 LOC101083265 DDC DDC DRD1 DRD1 BDNF BDNF LOC101086971 LOC101086971 GNG10 GNG10 H2BC3 H2BC3 LOC101085206 LOC101085206 GNAS GNAS H2BC5 H2BC5 SLC29A3 SLC29A3 H2AX H2AX CREB3 CREB3 GRIN1 GRIN1 CAMKK1 CAMKK1 HDAC10 HDAC10 LOC111558783 LOC111558783 CAMKK2 CAMKK2 PPP1R1B PPP1R1B GRIN2C GRIN2C CREB3L2 CREB3L2 GNG2 GNG2 ADCY5 ADCY5 GNB5 GNB5 H2BE1 H2BE1 GNG4 GNG4 GNAO1 GNAO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CAMK4Calcium/calmodulin dependent protein kinase IV. (638 aa)
CRHCorticotropin releasing hormone. (198 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (455 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SHC3SHC adaptor protein 3. (587 aa)
CALML6Calmodulin like 6. (180 aa)
CALML4Calmodulin like 4. (196 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
GNAI2G protein subunit alpha i2. (436 aa)
GNAI1G protein subunit alpha i1. (354 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
ATF4Activating transcription factor 4. (352 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (132 aa)
GNG13G protein subunit gamma 13. (67 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
SLC18A1Solute carrier family 18 member A1. (519 aa)
GNB3G protein subunit beta 3. (339 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
SLC18A2Solute carrier family 18 member A2. (517 aa)
MAOBAmine oxidase. (520 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (448 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
SHC2SHC adaptor protein 2. (583 aa)
LOC102900772Uncharacterized protein. (247 aa)
ATF6BActivating transcription factor 6 beta. (628 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1116 aa)
SLC29A2Solute carrier family 29 member 2. (456 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1338 aa)
KRASUncharacterized protein. (380 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
GNB1G protein subunit beta 1. (340 aa)
LOC101083005Histone H2A; Belongs to the histone H2A family. (130 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
M3WZ36_FELCAHistone H2A; Belongs to the histone H2A family. (140 aa)
LOC101096314Histone H2B; Belongs to the histone H2B family. (126 aa)
H3F3AHistone H3; Belongs to the histone H3 family. (136 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (129 aa)
LOC101088423Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
GNB2G protein subunit beta 2. (340 aa)
GNG14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
LOC101092488Histone domain-containing protein; Belongs to the histone H2B family. (127 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
LOC101097798Histone H2A; Belongs to the histone H2A family. (113 aa)
H2AWHistone H2A; Belongs to the histone H2A family. (130 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
H2AC1Histone H2A; Belongs to the histone H2A family. (131 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
M3XGB0_FELCAHistone H2A; Belongs to the histone H2A family. (155 aa)
LOC101087401Histone H2A; Belongs to the histone H2A family. (128 aa)
GNB4G protein subunit beta 4. (340 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
GNAI3G protein subunit alpha i3. (354 aa)
PDYNProdynorphin. (255 aa)
LOC101097703EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa)
ENSFCAP00000028809Histone H2B; Belongs to the histone H2B family. (67 aa)
PKIAcAMP-dependent protein kinase inhibitor alpha. (120 aa)
SHC4SHC adaptor protein 4. (630 aa)
HDAC11Histone deacetylase 11. (357 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
CREB5cAMP responsive element binding protein 5. (523 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (498 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
HDAC2Histone deacetylase 2. (602 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1068 aa)
LOC101093519Histone H2A; Belongs to the histone H2A family. (130 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1083 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (333 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
THInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (557 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
LOC101082235Histone H2B; Belongs to the histone H2B family. (126 aa)
HIST2H3CHistone cluster 2 H3 family member c. (258 aa)
LOC105260541Histone H3; Belongs to the histone H3 family. (136 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (659 aa)
ENSFCAP00000042498Histone domain-containing protein; Belongs to the histone H2B family. (118 aa)
ENSFCAP00000043372Histone H3; Belongs to the histone H3 family. (136 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
ENSFCAP00000043586Uncharacterized protein. (261 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1486 aa)
HDAC6Histone deacetylase 6. (1178 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1070 aa)
LOC101088237Histone H2A; Belongs to the histone H2A family. (130 aa)
MAOAAmine oxidase. (1178 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
LOC101083265Histone H2A; Belongs to the histone H2A family. (130 aa)
DDCDopa decarboxylase. (480 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (463 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (255 aa)
LOC101086971Histone H2B; Belongs to the histone H2B family. (126 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101085206Histone H2A; Belongs to the histone H2A family. (132 aa)
GNASGNAS complex locus. (968 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
SLC29A3Solute carrier family 29 member 3. (495 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
CREB3cAMP responsive element binding protein 3. (399 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (1008 aa)
CAMKK1Calcium/calmodulin dependent protein kinase kinase 1. (509 aa)
HDAC10Histone deacetylase 10. (546 aa)
LOC111558783Histone H2A; Belongs to the histone H2A family. (111 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (683 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (209 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C. (1325 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (536 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (152 aa)
ADCY5Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1329 aa)
GNB5G protein subunit beta 5. (403 aa)
H2BE1Histone H2B; Belongs to the histone H2B family. (122 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (250 aa)
GNAO1G protein subunit alpha o1. (370 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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