STRINGSTRING
BAX BAX TRAF2 TRAF2 RAB9B RAB9B STX10 STX10 FLNC FLNC TXN2 TXN2 VPS11 VPS11 CD14 CD14 CSE1L CSE1L VPS16 VPS16 CYTH2 CYTH2 RAB5C RAB5C MAPK10 MAPK10 DYNLRB1 DYNLRB1 ARPC2 ARPC2 HRAS HRAS CTNNB1 CTNNB1 AKT3 AKT3 RHOG RHOG ARPC3 ARPC3 PAK1 PAK1 KLC2 KLC2 PFN4 PFN4 PIK3CG PIK3CG ELMO1 ELMO1 CXCL8 CXCL8 DNM2 DNM2 AKT1 AKT1 RIPK3 RIPK3 IL1B IL1B NLRC4 NLRC4 NFKBIA NFKBIA ACTG1 ACTG1 TNFRSF1A TNFRSF1A GAPDH GAPDH NFKB1 NFKB1 DYNC1LI1 DYNC1LI1 DYNLT1 DYNLT1 WASF3 WASF3 KLC4 KLC4 SLC29A1 SLC29A1 S100A10 S100A10 IRAK1 IRAK1 PFN1 PFN1 BRK1 BRK1 TAB2 TAB2 PLEKHM2 PLEKHM2 MAPK11 MAPK11 RPS3 RPS3 TAB1 TAB1 MAP2K4 MAP2K4 RHOH RHOH FBXO22 FBXO22 CYFIP1 CYFIP1 MYLPF MYLPF RAB5B RAB5B BIRC3 BIRC3 MAP2K2 MAP2K2 RIPK1 RIPK1 PIK3C2B PIK3C2B ARPC1A ARPC1A ARPC5 ARPC5 MAP2K6 MAP2K6 MYL5 MYL5 RIPK2 RIPK2 ACBD3 ACBD3 VPS33A VPS33A RHOJ RHOJ KPNA3 KPNA3 RAB7A RAB7A KPNA4 KPNA4 MAP3K7 MAP3K7 ARPC4 ARPC4 RHOA RHOA RALA RALA DYNC1LI2 DYNC1LI2 RAB9A RAB9A IRAK4 IRAK4 ABI1 ABI1 LY96 LY96 LOC101101369 LOC101101369 TLR2 TLR2 NLRP3 NLRP3 RRAS RRAS IKBKG IKBKG JUN JUN ARPC5L ARPC5L SNX18 SNX18 EXOC4 EXOC4 MAP2K1 MAP2K1 LOC101100947 LOC101100947 TAB3 TAB3 ARF1 ARF1 LOC101100956 LOC101100956 PIK3CD PIK3CD TLR4 TLR4 MAPK14 MAPK14 GCC2 GCC2 DYNC2LI1 DYNC2LI1 CDC42-2 CDC42-2 PIK3C3 PIK3C3 MAPK1 MAPK1 MYL9 MYL9 WASL WASL IL18 IL18 TLR5 TLR5 PIK3CB PIK3CB NCKAP1 NCKAP1 MYL10 MYL10 PKN1 PKN1 ELMO2 ELMO2 MAPK12 MAPK12 VPS41 VPS41 NAIP NAIP CASP3 CASP3 EXOC2 EXOC2 RAF1 RAF1 PLEKHM1 PLEKHM1 KLC1 KLC1 MAPK3 MAPK3 PIK3C2G PIK3C2G DYNC2H1 DYNC2H1 PIK3C2A PIK3C2A FLNB FLNB MYD88 MYD88 TCF7L1 TCF7L1 DYNLL1 DYNLL1 PIK3CA PIK3CA ARHGEF26 ARHGEF26 NOD1 NOD1 MAPK8 MAPK8 TLR9 TLR9 FLNA FLNA DYNLL2 DYNLL2 EXOC7 EXOC7 MYL12A MYL12A TXN TXN LOC101089059 LOC101089059 DYNLRB2 DYNLRB2 HSP90AA1 HSP90AA1 AHNAK AHNAK NCKAP1L NCKAP1L PFN2 PFN2 CYTH1 CYTH1 EXOC5 EXOC5 IKBKB IKBKB FADD FADD DYNC1I2 DYNC1I2 TRADD TRADD MYC MYC ANXA2 ANXA2 FOS FOS RAB5A RAB5A MAP2K7 MAP2K7 PAK3 PAK3 MAPK9 MAPK9 TRAF6 TRAF6 RELA RELA DYNLT3 DYNLT3 MYL7 MYL7 LEF1 LEF1 TCF7L2 TCF7L2 PYCARD PYCARD TNF TNF KPNA1 KPNA1 TNFSF10 TNFSF10 FYCO1 FYCO1 CYFIP2 CYFIP2 VPS18 VPS18 DYNC1H1 DYNC1H1 LOC105261012 LOC105261012 AHNAK2 AHNAK2 TLR6 TLR6 CASP8 CASP8 M6PR M6PR VPS39 VPS39 MYL2 MYL2 CASP7 CASP7 SNX33 SNX33 CYTH4 CYTH4 MYO6 MYO6 HSP90B1 HSP90B1 ROCK2 ROCK2 KLC3 KLC3 CYTH3 CYTH3 RAB7B RAB7B ARF6 ARF6 AKT2 AKT2 MAP2K3 MAP2K3 SKP1 SKP1 CHUK CHUK PODXL PODXL BCL2 BCL2 FHOD1 FHOD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BAXBCL2 associated X, apoptosis regulator. (192 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
RAB9BRAB9B, member RAS oncogene family. (201 aa)
STX10Syntaxin 10; Belongs to the syntaxin family. (249 aa)
FLNCFilamin C. (2719 aa)
TXN2Thioredoxin 2. (163 aa)
VPS11Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (941 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
CSE1LChromosome segregation 1 like. (973 aa)
VPS16Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (839 aa)
CYTH2Uncharacterized protein. (400 aa)
RAB5CUncharacterized protein. (216 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
DYNLRB1Dynein light chain roadblock; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. (96 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CTNNB1Catenin beta 1. (783 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RHOGRas homolog family member G. (191 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
KLC2Kinesin light chain 2. (622 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
ELMO1Engulfment and cell motility 1. (742 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (867 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (509 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
NLRC4NLR family CARD domain containing 4. (1022 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
ACTG1Actin gamma 1. (375 aa)
TNFRSF1ATNF receptor superfamily member 1A. (444 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (333 aa)
NFKB1Nuclear factor kappa B subunit 1. (989 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (524 aa)
DYNLT1Dynein light chain Tctex-type 1. (113 aa)
WASF3WASP family member 3. (502 aa)
KLC4Kinesin light chain 4. (615 aa)
SLC29A1Heat shock protein 90 alpha family class B member 1. (740 aa)
S100A10S100 calcium binding protein A10; Belongs to the S-100 family. (97 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (724 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
PLEKHM2Pleckstrin homology and RUN domain containing M2. (1242 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
RPS3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (411 aa)
RHOHRas homolog family member H. (191 aa)
FBXO22F-box protein 22. (409 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (170 aa)
RAB5BRAB5B, member RAS oncogene family. (215 aa)
BIRC3Baculoviral IAP repeat containing 3. (624 aa)
MAP2K2Protein kinase domain-containing protein. (549 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (397 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
MYL5Myosin light chain 5. (174 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
ACBD3Acyl-CoA binding domain containing 3. (528 aa)
VPS33AUncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (596 aa)
RHOJRas homolog family member J. (236 aa)
KPNA3Importin subunit alpha; Functions in nuclear protein import. (521 aa)
RAB7AUncharacterized protein. (207 aa)
KPNA4Importin subunit alpha; Functions in nuclear protein import. (521 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (187 aa)
RHOARas homolog family member A. (193 aa)
RALARAS like proto-oncogene A. (206 aa)
DYNC1LI2Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (492 aa)
RAB9ARAB9A, member RAS oncogene family. (201 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (492 aa)
ABI1Abl interactor 1. (508 aa)
LY96Lymphocyte antigen 96. (160 aa)
LOC101101369Uncharacterized protein; Belongs to the profilin family. (152 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
NLRP3NLR family pyrin domain containing 3. (1038 aa)
RRASRAS related. (218 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
SNX18Sorting nexin. (624 aa)
EXOC4Exocyst complex component 4. (975 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
LOC101100947Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
ARF1ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (200 aa)
LOC101100956Uncharacterized protein. (129 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
GCC2GRIP and coiled-coil domain containing 2. (1683 aa)
DYNC2LI1Dynein cytoplasmic 2 light intermediate chain 1. (352 aa)
CDC42-2Uncharacterized protein. (191 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
MYL9Myosin light chain 9. (172 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (890 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
NCKAP1NCK associated protein 1. (1134 aa)
MYL10Myosin light chain 10. (167 aa)
PKN1Protein kinase N1. (1064 aa)
ELMO2Engulfment and cell motility 2. (732 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
VPS41Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (854 aa)
NAIPNACHT domain-containing protein. (1436 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
EXOC2Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (924 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
PLEKHM1Pleckstrin homology and RUN domain containing M1. (1066 aa)
KLC1Uncharacterized protein. (628 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PIK3C2GPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1486 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4314 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1688 aa)
FLNBFilamin B. (2633 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa)
TCF7L1Transcription factor 7 like 1. (586 aa)
DYNLL1Dynein light chain. (89 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ARHGEF26Rho guanine nucleotide exchange factor 26. (870 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
FLNAFilamin A. (2808 aa)
DYNLL2Dynein light chain. (89 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (737 aa)
MYL12AMyosin light chain 12A. (178 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
LOC101089059Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
DYNLRB2Dynein light chain roadblock; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. (99 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (753 aa)
AHNAKUncharacterized protein. (2539 aa)
NCKAP1LNCK associated protein 1 like. (1179 aa)
PFN2Profilin; Belongs to the profilin family. (188 aa)
CYTH1Cytohesin 1. (412 aa)
EXOC5Exocyst complex component 5. (708 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa)
DYNC1I2Dynein cytoplasmic 1 intermediate chain 2. (714 aa)
TRADDTNFRSF1A associated via death domain. (311 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (439 aa)
ANXA2Annexin. (339 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
RAB5ARAB5A, member RAS oncogene family. (240 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
PAK3P21 (RAC1) activated kinase 3. (589 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
DYNLT3Dynein light chain Tctex-type 3. (153 aa)
MYL7Myosin light chain 7. (216 aa)
LEF1Lymphoid enhancer binding factor 1. (415 aa)
TCF7L2Transcription factor 7 like 2. (673 aa)
PYCARDPYD and CARD domain containing. (195 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
KPNA1Importin subunit alpha; Functions in nuclear protein import. (564 aa)
TNFSF10TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (347 aa)
FYCO1FYVE and coiled-coil domain containing 1. (1459 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1335 aa)
VPS18VPS18 core subunit of CORVET and HOPS complexes. (1096 aa)
DYNC1H1Dynein cytoplasmic 1 heavy chain 1. (4670 aa)
LOC105261012Uncharacterized protein. (427 aa)
AHNAK2Uncharacterized protein. (769 aa)
TLR6Toll like receptor 6; Belongs to the Toll-like receptor family. (833 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (479 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (438 aa)
VPS39VPS39 subunit of HOPS complex. (956 aa)
MYL2Myosin light chain 2. (174 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (409 aa)
SNX33Sorting nexin. (577 aa)
CYTH4Cytohesin 4. (443 aa)
MYO6Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1294 aa)
HSP90B1Heat shock protein 90 beta family member 1. (809 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1471 aa)
KLC3Kinesin light chain 3. (637 aa)
CYTH3Cytohesin 3. (648 aa)
RAB7BRAB7B, member RAS oncogene family. (297 aa)
ARF6Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (140 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (383 aa)
SKP1Uncharacterized protein; Belongs to the SKP1 family. (168 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
PODXLPodocalyxin like. (594 aa)
BCL2BCL2 apoptosis regulator. (237 aa)
FHOD1Formin homology 2 domain containing 1. (1182 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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