STRINGSTRING
C1R C1R C1QB C1QB C5 C5 CD14 CD14 TICAM2 TICAM2 MAPK10 MAPK10 CXCL8 CXCL8 ITGAM ITGAM IL1B IL1B IRF3 IRF3 CALML6 CALML6 CALML4 CALML4 GNAI2 GNAI2 GNAI1 GNAI1 NFKB1 NFKB1 IL1A IL1A CFL2 CFL2 ITGA5 ITGA5 IRAK1 IRAK1 IL12A IL12A MAPK11 MAPK11 IL23A IL23A CFL1 CFL1 IRF1 IRF1 IL10 IL10 C4BPB C4BPB C4BPA C4BPA CXCL6 CXCL6 CALM2 CALM2 C1QA C1QA RHOA RHOA IRAK4 IRAK4 LY96 LY96 NLRP3 NLRP3 JUN JUN TLR4 TLR4 MAPK14 MAPK14 MAPK1 MAPK1 IL12B IL12B CALML3 CALML3 GNAI3 GNAI3 LOC101097703 LOC101097703 MAPK12 MAPK12 ITGB1 ITGB1 CASP3 CASP3 LOC101101085 LOC101101085 MAPK3 MAPK3 MYD88 MYD88 NOS2 NOS2 ITGB2 ITGB2 NOD1 NOD1 MAPK8 MAPK8 TICAM1 TICAM1 ENSFCAP00000043586 ENSFCAP00000043586 FOS FOS MAPK9 MAPK9 TRAF6 TRAF6 RELA RELA IRF8 IRF8 C1QC C1QC PYCARD PYCARD TNF TNF LOC101094346 LOC101094346 C1S C1S C2 C2 CASP7 CASP7 SERPING1 SERPING1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C1RPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (293 aa)
C1QBComplement C1q B chain. (254 aa)
C5Complement C5. (1680 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
TICAM2Toll like receptor adaptor molecule 2. (234 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1173 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
IRF3Interferon regulatory factor 3. (420 aa)
CALML6Calmodulin like 6. (180 aa)
CALML4Calmodulin like 4. (196 aa)
GNAI2G protein subunit alpha i2. (436 aa)
GNAI1G protein subunit alpha i1. (354 aa)
NFKB1Nuclear factor kappa B subunit 1. (989 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1104 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (724 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
IL23AInterleukin 23 subunit alpha. (196 aa)
CFL1ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (166 aa)
IRF1Interferon regulatory factor. (322 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
C4BPBComplement component 4 binding protein beta. (259 aa)
C4BPAUncharacterized protein. (599 aa)
CXCL6C-X-C motif chemokine. (148 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
C1QAComplement C1q A chain. (245 aa)
RHOARas homolog family member A. (193 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (492 aa)
LY96Lymphocyte antigen 96. (160 aa)
NLRP3NLR family pyrin domain containing 3. (1038 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
GNAI3G protein subunit alpha i3. (354 aa)
LOC101097703EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
LOC101101085C-type lectin domain-containing protein. (257 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1165 aa)
ITGB2Integrin beta. (867 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TICAM1Toll like receptor adaptor molecule 1. (815 aa)
ENSFCAP00000043586Uncharacterized protein. (261 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
IRF8Interferon regulatory factor 8. (427 aa)
C1QCComplement C1q C chain. (245 aa)
PYCARDPYD and CARD domain containing. (195 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
LOC101094346Uncharacterized protein. (1908 aa)
C1SComplement C1s; Belongs to the peptidase S1 family. (710 aa)
C2Complement C2; Belongs to the peptidase S1 family. (870 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (409 aa)
SERPING1Serpin family G member 1; Belongs to the serpin family. (512 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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