STRINGSTRING
JAK1 JAK1 PDPK1 PDPK1 STAT3 STAT3 MAPK10 MAPK10 NFKBIB NFKBIB AKT3 AKT3 PIK3R6 PIK3R6 HSPA1L HSPA1L LAMB1 LAMB1 LAMB4 LAMB4 PIK3CG PIK3CG AKT1 AKT1 LAMC3 LAMC3 TGFB1 TGFB1 NFKBIA NFKBIA TNFRSF1A TNFRSF1A GNAI2 GNAI2 GNAI1 GNAI1 NFKB1 NFKB1 HSPA2 HSPA2 LAMA1 LAMA1 IFNG IFNG TYK2 TYK2 LAMA3 LAMA3 LOC101090518 LOC101090518 LAMB2 LAMB2 LAMC2 LAMC2 IRAK1 IRAK1 IL12A IL12A TAB2 TAB2 IL10RA IL10RA MAPK11 MAPK11 TAB1 TAB1 XIAP XIAP ALOX5 ALOX5 IL10 IL10 CD40 CD40 BIRC3 BIRC3 TGFB3 TGFB3 MAP2K6 MAP2K6 MAP3K7 MAP3K7 CASP9 CASP9 IRAK4 IRAK4 LAMC1 LAMC1 LY96 LY96 TLR2 TLR2 IKBKG IKBKG LOC101100947 LOC101100947 IFNGR1 IFNGR1 TLR4 TLR4 MAPK14 MAPK14 PPIF PPIF MAPK1 MAPK1 LAMB3 LAMB3 IL12B IL12B GNAI3 GNAI3 MAPK12 MAPK12 ITGB1 ITGB1 CASP3 CASP3 CD40LG CD40LG SLC26A3-2 SLC26A3-2 MAPK3 MAPK3 ITGA6 ITGA6 MYD88 MYD88 NOS2 NOS2 HSPA8 HSPA8 LOC101082653 LOC101082653 MAPK8 MAPK8 IFNGR2 IFNGR2 LOC101084962 LOC101084962 LOC101090265 LOC101090265 IKBKB IKBKB LOC111558970 LOC111558970 LOC101082906 LOC101082906 LOC101090771 LOC101090771 BAD BAD MAPK9 MAPK9 TRAF6 TRAF6 SOCS1 SOCS1 RELA RELA JAK2 JAK2 STAT1 STAT1 LDLR LDLR TNF TNF LOC111560444 LOC111560444 LOC101084108 LOC101084108 LAMA2 LAMA2 LAMA4 LAMA4 CCR5 CCR5 CASP8 CASP8 LOC111556169 LOC111556169 BCL2L1 BCL2L1 LOC111560443 LOC111560443 AKT2 AKT2 PIK3R5 PIK3R5 MAP2K3 MAP2K3 IL10RB IL10RB CHUK CHUK GNAO1 GNAO1 BCL2 BCL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAK1Tyrosine-protein kinase. (1157 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
NFKBIBNFKB inhibitor beta. (354 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (755 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
LAMB1Laminin subunit beta 1. (1786 aa)
LAMB4Laminin subunit beta 4. (1747 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LAMC3Laminin subunit gamma 3. (1573 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
TNFRSF1ATNF receptor superfamily member 1A. (444 aa)
GNAI2G protein subunit alpha i2. (436 aa)
GNAI1G protein subunit alpha i1. (354 aa)
NFKB1Nuclear factor kappa B subunit 1. (989 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (639 aa)
LAMA1Laminin subunit alpha 1. (3080 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
TYK2Tyrosine-protein kinase. (1181 aa)
LAMA3Laminin subunit alpha 3. (3332 aa)
LOC101090518Ig-like domain-containing protein; Belongs to the MHC class II family. (250 aa)
LAMB2Laminin subunit beta 2. (1801 aa)
LAMC2Laminin subunit gamma 2. (1191 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (724 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
IL10RAInterleukin 10 receptor subunit alpha. (578 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
XIAPX-linked inhibitor of apoptosis. (454 aa)
ALOX5Arachidonate 5-lipoxygenase. (745 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
CD40CD40 molecule. (324 aa)
BIRC3Baculoviral IAP repeat containing 3. (624 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (451 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (492 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
LY96Lymphocyte antigen 96. (160 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa)
LOC101100947Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
IFNGR1Interferon gamma receptor 1. (469 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (204 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
LAMB3Laminin subunit beta 3. (1217 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa)
GNAI3G protein subunit alpha i3. (354 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (260 aa)
SLC26A3-2Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1165 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (667 aa)
LOC101082653Ig-like domain-containing protein. (276 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IFNGR2Interferon gamma receptor 2. (390 aa)
LOC101084962Ig-like domain-containing protein. (253 aa)
LOC101090265Ig-like domain-containing protein. (263 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
LOC111558970Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa)
LOC101082906Ig-like domain-containing protein. (282 aa)
LOC101090771Ig-like domain-containing protein; Belongs to the MHC class II family. (257 aa)
BADBCL2 associated agonist of cell death. (273 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
SOCS1Suppressor of cytokine signaling 1. (203 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
STAT1Signal transducer and activator of transcription. (885 aa)
LDLRLow density lipoprotein receptor. (866 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
LOC111560444Ig-like domain-containing protein; Belongs to the MHC class II family. (250 aa)
LOC101084108Ig-like domain-containing protein; Belongs to the MHC class II family. (344 aa)
LAMA2Laminin subunit alpha 2. (3125 aa)
LAMA4Laminin subunit alpha 4. (1856 aa)
CCR5G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (352 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (479 aa)
LOC111556169Ig-like domain-containing protein. (276 aa)
BCL2L1BCL2 like 1. (271 aa)
LOC111560443Ig-like domain-containing protein; Belongs to the MHC class II family. (322 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (904 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (383 aa)
IL10RBInterleukin 10 receptor subunit beta. (390 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
GNAO1G protein subunit alpha o1. (370 aa)
BCL2BCL2 apoptosis regulator. (237 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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