STRINGSTRING
C8G C8G LOC101100279 LOC101100279 SERPINB9 SERPINB9 LOC101080762 LOC101080762 CD14 CD14 PRKCG PRKCG RAB5C RAB5C CSF2 CSF2 LAMB1 LAMB1 LAMB4 LAMB4 COL1A1 COL1A1 CXCL8 CXCL8 LAMC3 LAMC3 ITGAM ITGAM TGFB1 TGFB1 IL1B IL1B GNA15 GNA15 NFKB1 NFKB1 SERPINB3 SERPINB3 SERPINB10 SERPINB10 GNA14 GNA14 CD1B CD1B LAMA1 LAMA1 IFNG IFNG FN1 FN1 LAMA3 LAMA3 LAMB2 LAMB2 LAMC2 LAMC2 PIK3R1 PIK3R1 PRKCB PRKCB IL12A IL12A PRKCA PRKCA IL1R2 IL1R2 IL1R1 IL1R1 C9 C9 IL10 IL10 RAB5B RAB5B ARG2 ARG2 TGFB3 TGFB3 COL3A1 COL3A1 COL4A1 COL4A1 LOC102900772 LOC102900772 RAB7A RAB7A COL1A2 COL1A2 PRKACA PRKACA HSPB1 HSPB1 LAMC1 LAMC1 TLR2 TLR2 PIK3CD PIK3CD TLR4 TLR4 VCL VCL GNAQ GNAQ LAMB3 LAMB3 CD1E CD1E IL12B IL12B ACTN4 ACTN4 PIK3CB PIK3CB C8B C8B CASP3 CASP3 PTK2 PTK2 PLCB2 PLCB2 PIK3CA PIK3CA NOS2 NOS2 PRDX1 PRDX1 ITGB2 ITGB2 PRKACB PRKACB GNAL GNAL LOC111559157 LOC111559157 PLCB1 PLCB1 GNA11 GNA11 COL4A3 COL4A3 PIK3R2 PIK3R2 COL4A6 COL4A6 RAB5A RAB5A SERPINB6 SERPINB6 PIK3R3 PIK3R3 COL4A5 COL4A5 RELA RELA CTSG CTSG TNF TNF ACTN1 ACTN1 GNAS GNAS COL4A2 COL4A2 LAMA2 LAMA2 LAMA4 LAMA4 PLCB4 PLCB4 PLCB3 PLCB3 ADCY1 ADCY1 C8A C8A ARG1 ARG1 MUC2 MUC2 RAB7B RAB7B LOC105260178 LOC105260178
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C8GComplement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family. (202 aa)
LOC101100279Ig-like domain-containing protein. (413 aa)
SERPINB9Serpin family B member 9; Belongs to the serpin family. (447 aa)
LOC101080762Ig-like domain-containing protein. (331 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
RAB5CUncharacterized protein. (216 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (142 aa)
LAMB1Laminin subunit beta 1. (1786 aa)
LAMB4Laminin subunit beta 4. (1747 aa)
COL1A1Collagen type I alpha 1 chain. (1461 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
LAMC3Laminin subunit gamma 3. (1573 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1173 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
GNA15G protein subunit alpha 15. (427 aa)
NFKB1Nuclear factor kappa B subunit 1. (989 aa)
SERPINB3SERPIN domain-containing protein; Belongs to the serpin family. (389 aa)
SERPINB10Serpin family B member 10; Belongs to the serpin family. (396 aa)
GNA14G protein subunit alpha 14. (355 aa)
CD1BCD1b molecule. (332 aa)
LAMA1Laminin subunit alpha 1. (3080 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
FN1Fibronectin 1. (2475 aa)
LAMA3Laminin subunit alpha 3. (3332 aa)
LAMB2Laminin subunit beta 2. (1801 aa)
LAMC2Laminin subunit gamma 2. (1191 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
IL1R2Interleukin 1 receptor type 2. (418 aa)
IL1R1Interleukin 1 receptor type 1. (572 aa)
C9Complement C9. (562 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
RAB5BRAB5B, member RAS oncogene family. (215 aa)
ARG2Arginase. (354 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
LOC102900772Uncharacterized protein. (247 aa)
RAB7AUncharacterized protein. (207 aa)
COL1A2Collagen type I alpha 2 chain. (1367 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (205 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
VCLVinculin. (1066 aa)
GNAQG protein subunit alpha q. (359 aa)
LAMB3Laminin subunit beta 3. (1217 aa)
CD1ECD1e molecule. (419 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa)
ACTN4Actinin alpha 4. (933 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
C8BComplement C8 beta chain. (637 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1112 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1188 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1165 aa)
PRDX1Peroxiredoxin 1. (229 aa)
ITGB2Integrin beta. (867 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
GNALG protein subunit alpha L. (455 aa)
LOC111559157Ig-like domain-containing protein. (280 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNA11G protein subunit alpha 11. (359 aa)
COL4A3Collagen type IV alpha 3 chain. (1669 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
RAB5ARAB5A, member RAS oncogene family. (240 aa)
SERPINB6SERPIN domain-containing protein; Belongs to the serpin family. (396 aa)
PIK3R3Uncharacterized protein. (461 aa)
COL4A5Collagen type IV alpha 5 chain. (1689 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (292 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
ACTN1Actinin alpha 1. (927 aa)
GNASGNAS complex locus. (968 aa)
COL4A2Collagen type IV alpha 2 chain. (1854 aa)
LAMA2Laminin subunit alpha 2. (3125 aa)
LAMA4Laminin subunit alpha 4. (1856 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1209 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1245 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa)
C8AComplement C8 alpha chain. (640 aa)
ARG1Arginase. (329 aa)
MUC2Uncharacterized protein. (921 aa)
RAB7BRAB7B, member RAS oncogene family. (297 aa)
LOC105260178Ig-like domain-containing protein. (357 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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