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| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | FCGR3A | CD16. (250 aa) |
| | CD14 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (375 aa) |
| | HSPA9 | Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa) |
| | JAK1 | Tyrosine-protein kinase. (1157 aa) |
| | RAB5C | Uncharacterized protein. (216 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | LAMP2 | Lysosomal associated membrane protein 2. (470 aa) |
| | IFNB1 | Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (482 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | EP300 | E1A binding protein p300. (2425 aa) |
| | ITGAM | Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1173 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | SPHK1 | Sphingosine kinase 1. (473 aa) |
| | RFX5 | Regulatory factor X5. (611 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa) |
| | CALML6 | Calmodulin like 6. (180 aa) |
| | CREBBP | CREB binding protein. (2444 aa) |
| | ATP6V0B | ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family. (205 aa) |
| | CALML4 | Calmodulin like 4. (196 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (444 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (989 aa) |
| | CTSD | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (408 aa) |
| | ATP6V0D2 | V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1014 aa) |
| | CAMP | Cathelicidin antimicrobial peptide. (171 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa) |
| | KSR1 | Kinase suppressor of ras 1. (928 aa) |
| | LOC101090518 | Ig-like domain-containing protein; Belongs to the MHC class II family. (250 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (698 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (724 aa) |
| | MRC2 | Mannose receptor C type 2. (1482 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (618 aa) |
| | ATP6AP1 | ATPase H+ transporting accessory protein 1. (465 aa) |
| | IL10RA | Interleukin 10 receptor subunit alpha. (578 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | IL23A | Interleukin 23 subunit alpha. (196 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) |
| | RAB5B | RAB5B, member RAS oncogene family. (215 aa) |
| | MALT1 | MALT1 paracaspase. (848 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | SYK | Spleen associated tyrosine kinase. (636 aa) |
| | LAMP1 | Lysosomal associated membrane protein 1. (422 aa) |
| | ATP6V1H | V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (483 aa) |
| | CYP27B1 | Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa) |
| | CALM2 | Calmodulin 2; Belongs to the calmodulin family. (149 aa) |
| | RAB7A | Uncharacterized protein. (207 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (451 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (492 aa) |
| | HSPD1 | Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (573 aa) |
| | CD209 | C-type lectin domain-containing protein. (250 aa) |
| | LOC101088440 | Uncharacterized protein. (183 aa) |
| | TLR2 | Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa) |
| | LOC101087936 | Uncharacterized protein. (373 aa) |
| | PLA2R1 | Phospholipase A2 receptor 1. (1463 aa) |
| | VDR | Vitamin D receptor. (441 aa) |
| | LOC101100947 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | IFNGR1 | Interferon gamma receptor 1. (469 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (525 aa) |
| | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa) |
| | RFXAP | Regulatory factor X associated protein. (234 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1543 aa) |
| | CALML3 | Calmodulin like 3; Belongs to the calmodulin family. (149 aa) |
| | LOC101097703 | EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (367 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | IFNA1 | Interferon alpha; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (194 aa) |
| | ATP6V0A4 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (840 aa) |
| | SLC26A3-2 | Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | NFYB | Nuclear transcription factor Y subunit beta. (207 aa) |
| | EEA1 | Early endosome antigen 1. (1457 aa) |
| | CNRIP1 | Uncharacterized protein. (324 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (521 aa) |
| | CLEC4E | C-type lectin domain family 4 member E. (228 aa) |
| | NOS2 | Nitric oxide synthase; Produces nitric oxide (NO). (1165 aa) |
| | ITGB2 | Integrin beta. (867 aa) |
| | FCER1G | Fc fragment of IgE receptor Ig. (86 aa) |
| | LOC101082653 | Ig-like domain-containing protein. (276 aa) |
| | CORO1A | Coronin; Belongs to the WD repeat coronin family. (655 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | TLR9 | Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa) |
| | ATP6V0A1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (863 aa) |
| | IFNA13 | Uncharacterized protein. (193 aa) |
| | IFNGR2 | Interferon gamma receptor 2. (390 aa) |
| | TCIRG1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (954 aa) |
| | LOC101084962 | Ig-like domain-containing protein. (253 aa) |
| | SRC | Tyrosine-protein kinase. (678 aa) |
| | LOC101090265 | Ig-like domain-containing protein. (263 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (523 aa) |
| | SPHK2 | DAGKc domain-containing protein. (660 aa) |
| | ENSFCAP00000043586 | Uncharacterized protein. (261 aa) |
| | CAMK2B | Calcium/calmodulin dependent protein kinase II beta. (748 aa) |
| | LOC111558970 | Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa) |
| | LOC101082906 | Ig-like domain-containing protein. (282 aa) |
| | TRADD | TNFRSF1A associated via death domain. (311 aa) |
| | ATP6V0D1 | V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa) |
| | RAB5A | RAB5A, member RAS oncogene family. (240 aa) |
| | LOC101090771 | Ig-like domain-containing protein; Belongs to the MHC class II family. (257 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa) |
| | BAD | BCL2 associated agonist of cell death. (273 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa) |
| | ATP6V0A2 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (995 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (555 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (346 aa) |
| | JAK2 | Tyrosine-protein kinase. (1131 aa) |
| | CEBPG | BZIP domain-containing protein. (465 aa) |
| | NFYC | Nuclear transcription factor Y subunit gamma. (439 aa) |
| | BCL10 | BCL10 immune signaling adaptor. (233 aa) |
| | STAT1 | Signal transducer and activator of transcription. (885 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa) |
| | LOC111560444 | Ig-like domain-containing protein; Belongs to the MHC class II family. (250 aa) |
| | MRC1 | Mannose receptor C-type 1. (1484 aa) |
| | LOC101084108 | Ig-like domain-containing protein; Belongs to the MHC class II family. (344 aa) |
| | CTSK | Cathepsin S; Belongs to the peptidase C1 family. (445 aa) |
| | LSP1 | Lymphocyte specific protein 1. (573 aa) |
| | TLR6 | Toll like receptor 6; Belongs to the Toll-like receptor family. (833 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (479 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (205 aa) |
| | RPS14 | Calcium/calmodulin dependent protein kinase II alpha. (566 aa) |
| | ATP6V0C | V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa) |
| | LOC111556169 | Ig-like domain-containing protein. (276 aa) |
| | TLR1 | Toll like receptor 1; Belongs to the Toll-like receptor family. (789 aa) |
| | LOC111560443 | Ig-like domain-containing protein; Belongs to the MHC class II family. (322 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (571 aa) |
| | LBP | Lipopolysaccharide binding protein. (497 aa) |
| | IL10RB | Interleukin 10 receptor subunit beta. (390 aa) |
| | CAMK2D | Calcium/calmodulin dependent protein kinase II delta. (544 aa) |
| | LOC109498011 | Uncharacterized protein. (483 aa) |
| | BCL2 | BCL2 apoptosis regulator. (237 aa) |
| | ITGAX | VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1156 aa) |
