Your Input: | |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | OAS1 | 2'-5'-oligoadenylate synthetase 1. (401 aa) |
| | OAS3 | 2'-5'-oligoadenylate synthetase 3. (1087 aa) |
| | OAS2 | 2'-5'-oligoadenylate synthetase 2. (708 aa) |
| | CCL2 | C-C motif chemokine. (99 aa) |
| | CCL5 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa) |
| | DDX58 | DExD/H-box helicase 58. (929 aa) |
| | KPNA2 | Uncharacterized protein. (323 aa) |
| | JAK1 | Tyrosine-protein kinase. (1157 aa) |
| | XPO1 | Exportin 1. (1071 aa) |
| | PML | Promyelocytic leukemia. (876 aa) |
| | NFKBIB | NFKB inhibitor beta. (354 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | IFNB1 | Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa) |
| | CPSF4L | Cleavage and polyadenylation specific factor 4 like. (216 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | EP300 | E1A binding protein p300. (2425 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa) |
| | IRF3 | Interferon regulatory factor 3. (420 aa) |
| | CREBBP | CREB binding protein. (2444 aa) |
| | EIF2AK2 | Eukaryotic translation initiation factor 2 alpha kinase 2. (541 aa) |
| | NXT1 | Nuclear transport factor 2 like export factor 1. (140 aa) |
| | NFKBIA | NFKB inhibitor alpha. (314 aa) |
| | ACTG1 | Actin gamma 1. (375 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (444 aa) |
| | SLC25A5 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa) |
| | SLC25A31 | Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (989 aa) |
| | TRIM25 | Tripartite motif containing 25. (608 aa) |
| | TMPRSS2 | Transmembrane serine protease 2; Belongs to the peptidase S1 family. (492 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa) |
| | IL33 | Interleukin 33. (268 aa) |
| | ICAM1 | Intercellular adhesion molecule 1. (532 aa) |
| | TYK2 | Tyrosine-protein kinase. (1181 aa) |
| | LOC101090518 | Ig-like domain-containing protein; Belongs to the MHC class II family. (250 aa) |
| | PABPN1L | Poly(A) binding protein nuclear 1 like, cytoplasmic. (277 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa) |
| | STAT2 | Signal transducer and activator of transcription. (855 aa) |
| | LOC101093921 | Uncharacterized protein. (615 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (718 aa) |
| | TMPRSS11D | Transmembrane protease serine; Belongs to the peptidase S1 family. (418 aa) |
| | MAP2K2 | Protein kinase domain-containing protein. (549 aa) |
| | NXF1 | Nuclear RNA export factor 1. (618 aa) |
| | KPNA7 | Karyopherin subunit alpha 7. (326 aa) |
| | RAB11B | RAB11B, member RAS oncogene family. (218 aa) |
| | IRF9 | Interferon regulatory factor 9. (411 aa) |
| | LOC101085453 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (342 aa) |
| | IFNAR2 | Uncharacterized protein. (519 aa) |
| | DNAJC3 | DnaJ heat shock protein family (Hsp40) member C3. (504 aa) |
| | CDK4 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (451 aa) |
| | KPNA5 | Importin subunit alpha; Functions in nuclear protein import. (539 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (492 aa) |
| | IFIH1 | Interferon induced with helicase C domain 1. (1026 aa) |
| | SOCS3 | Suppressor of cytokine signaling 3. (225 aa) |
| | EIF2S1 | Eukaryotic translation initiation factor 2 subunit alpha. (315 aa) |
| | LOC101088440 | Uncharacterized protein. (183 aa) |
| | NLRP3 | NLR family pyrin domain containing 3. (1038 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa) |
| | PLG | Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (806 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | LOC101100947 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | IFNGR1 | Interferon gamma receptor 1. (469 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa) |
| | PABPN1 | Poly(A) binding protein nuclear 1. (306 aa) |
| | IFNAR1 | Interferon alpha and beta receptor subunit 1. (562 aa) |
| | RNASEL | Ribonuclease L. (724 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa) |
| | DNAJB1 | DnaJ heat shock protein family (Hsp40) member B1. (340 aa) |
| | FDPS | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (420 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa) |
| | FAS | Uncharacterized protein. (314 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (917 aa) |
| | RSAD2 | Radical S-adenosyl methionine domain containing 2. (363 aa) |
| | NUP98 | Nucleoporin 98. (1816 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | LOC101092919 | Uncharacterized protein. (633 aa) |
| | IFNA1 | Interferon alpha; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (194 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) |
| | SLC26A3-2 | Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | SLC25A4 | Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa) |
| | TRAF3 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa) |
| | NLRX1 | NLR family member X1. (975 aa) |
| | VDAC1 | Voltage dependent anion channel 1. (283 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | LOC101082653 | Ig-like domain-containing protein. (276 aa) |
| | NXT2 | Nuclear transport factor 2 like export factor 2. (151 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (292 aa) |
| | IFNA13 | Uncharacterized protein. (193 aa) |
| | IFNGR2 | Interferon gamma receptor 2. (390 aa) |
| | TLR7 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (1071 aa) |
| | KPNA6 | Importin subunit alpha; Functions in nuclear protein import. (536 aa) |
| | MAVS | Mitochondrial antiviral signaling protein. (662 aa) |
| | CPSF4 | Cleavage and polyadenylation specific factor 4. (269 aa) |
| | LOC101084962 | Ig-like domain-containing protein. (253 aa) |
| | LOC101090265 | Ig-like domain-containing protein. (263 aa) |
| | TICAM1 | Toll like receptor adaptor molecule 1. (815 aa) |
| | PIK3R2 | Phosphoinositide-3-kinase regulatory subunit 2. (726 aa) |
| | CXCL10 | C-X-C motif chemokine. (98 aa) |
| | HNRNPUL1 | Heterogeneous nuclear ribonucleoprotein U like 1. (856 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (760 aa) |
| | LOC111558970 | Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa) |
| | LOC101082906 | Ig-like domain-containing protein. (282 aa) |
| | ENSFCAP00000045499 | Tap-RNA_bind domain-containing protein. (341 aa) |
| | TRADD | TNFRSF1A associated via death domain. (311 aa) |
| | IRF7 | Interferon regulatory factor 7. (512 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | LOC101090771 | Ig-like domain-containing protein; Belongs to the MHC class II family. (257 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (555 aa) |
| | SLC25A6 | Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (318 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (338 aa) |
| | JAK2 | Tyrosine-protein kinase. (1131 aa) |
| | STAT1 | Signal transducer and activator of transcription. (885 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa) |
| | KPNA1 | Importin subunit alpha; Functions in nuclear protein import. (564 aa) |
| | TNFSF10 | TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (347 aa) |
| | LOC111560444 | Ig-like domain-containing protein; Belongs to the MHC class II family. (250 aa) |
| | LOC101084108 | Ig-like domain-containing protein; Belongs to the MHC class II family. (344 aa) |
| | LOC105261012 | Uncharacterized protein. (427 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (479 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (205 aa) |
| | MX1 | MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (675 aa) |
| | RAB11A | RAB11A, member RAS oncogene family. (217 aa) |
| | LOC111556169 | Ig-like domain-containing protein. (276 aa) |
| | LOC111560443 | Ig-like domain-containing protein; Belongs to the MHC class II family. (322 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (571 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (774 aa) |
