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| | ADCY6 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1208 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | CALR | Calreticulin. (417 aa) |
| | NFKB2 | Nuclear factor kappa B subunit 2. (921 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | JAK1 | Tyrosine-protein kinase. (1157 aa) |
| | KAT2A | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (836 aa) |
| | STAT5B | Signal transducer and activator of transcription. (786 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | SPI1 | Spi-1 proto-oncogene. (270 aa) |
| | XPO1 | Exportin 1. (1071 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | ADCY3 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | CSF2 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (142 aa) |
| | CD4 | CD4 molecule. (487 aa) |
| | KAT2B | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (834 aa) |
| | LTA | Tumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family. (205 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (421 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | EP300 | E1A binding protein p300. (2425 aa) |
| | E2F1 | E2F transcription factor 1. (436 aa) |
| | VAC14 | VAC14 component of PIKFYVE complex. (783 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (916 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | CDC26 | Cell division cycle 26. (85 aa) |
| | ADCY4 | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1010 aa) |
| | IL2RA | Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. (275 aa) |
| | ESPL1 | Extra spindle pole bodies like 1, separase. (2112 aa) |
| | NRP1 | Neuropilin; Belongs to the neuropilin family. (923 aa) |
| | CREBBP | CREB binding protein. (2444 aa) |
| | ADCY8 | Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa) |
| | NFKBIA | NFKB inhibitor alpha. (314 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (444 aa) |
| | TBP | TATA-box binding protein. (327 aa) |
| | SLC25A5 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa) |
| | SLC25A31 | Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa) |
| | TLN2 | Talin 2. (2542 aa) |
| | ETS2 | Protein C-ets-2; Transcription factor; Belongs to the ETS family. (469 aa) |
| | JAK3 | Tyrosine-protein kinase. (1232 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (989 aa) |
| | IL2RB | Interleukin 2 receptor subunit beta. (550 aa) |
| | LTBR | Lymphotoxin beta receptor. (433 aa) |
| | EGR2 | Early growth response 2. (541 aa) |
| | IL15RA | Interleukin 15 receptor subunit alpha. (268 aa) |
| | ATF4 | Activating transcription factor 4. (352 aa) |
| | CCNB2 | Cyclin B2; Belongs to the cyclin family. (397 aa) |
| | ICAM1 | Intercellular adhesion molecule 1. (532 aa) |
| | LOC101090518 | Ig-like domain-containing protein; Belongs to the MHC class II family. (250 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (1031 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | E2F2 | E2F transcription factor 2. (442 aa) |
| | CD3D | CD3d molecule. (170 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (411 aa) |
| | XIAP | X-linked inhibitor of apoptosis. (454 aa) |
| | IL1R2 | Interleukin 1 receptor type 2. (418 aa) |
| | IL1R1 | Interleukin 1 receptor type 1. (572 aa) |
| | B2M | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (118 aa) |
| | ANAPC5 | Anaphase promoting complex subunit 5. (755 aa) |
| | TLN1 | Talin 1. (2558 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa) |
| | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14. (954 aa) |
| | CD40 | CD40 molecule. (324 aa) |
| | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1. (1509 aa) |
| | MAP2K2 | Protein kinase domain-containing protein. (549 aa) |
| | CREB3L3 | cAMP responsive element binding protein 3 like 3. (448 aa) |
| | TGFB3 | Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa) |
| | CDC16 | Cell division cycle 16. (620 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa) |
| | MMP7 | Matrilysin; Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase; Belongs to the peptidase M10A family. (267 aa) |
| | ATF6B | Activating transcription factor 6 beta. (628 aa) |
| | LOC105260551 | Ig-like domain-containing protein; Belongs to the MHC class I family. (438 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa) |
| | CREB3L1 | cAMP responsive element binding protein 3 like 1. (520 aa) |
| | KRAS | Uncharacterized protein. (380 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | IL15 | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. (162 aa) |
| | BUB3 | BUB3 mitotic checkpoint protein. (328 aa) |
| | CDK4 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa) |
| | ADCY9 | Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa) |
| | PRKACA | Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa) |
| | RAN | GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (216 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | SRF | Serum response factor. (512 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (598 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa) |
| | VDAC2 | Voltage dependent anion channel 2. (294 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa) |
| | JUN | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (406 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | CRTC3 | CREB regulated transcription coactivator 3. (618 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1075 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | GPS2 | Uncharacterized protein. (327 aa) |
| | RB1 | RB transcriptional corepressor 1. (930 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (525 aa) |
| | ANAPC1 | Anaphase promoting complex subunit 1. (1943 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa) |
| | LOC101099296 | Ig-like domain-containing protein; Belongs to the MHC class I family. (357 aa) |
| | FDPS | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (420 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa) |
| | RELB | RELB proto-oncogene, NF-kB subunit. (582 aa) |
| | FOSL1 | FOS like 1, AP-1 transcription factor subunit. (273 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (543 aa) |
| | LOC101080790 | MHC_I-like_Ag-recog domain-containing protein. (216 aa) |
| | ADCY7 | Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa) |
| | MAP3K3 | Uncharacterized protein. (626 aa) |
| | CDKN2C | Cyclin dependent kinase inhibitor 2C. (168 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | MAD2L1 | Mitotic arrest deficient 2 like 1. (221 aa) |
| | CREB5 | cAMP responsive element binding protein 5. (523 aa) |
| | CDC20 | Cell division cycle 20. (499 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | TSPO2 | Translocator protein 2. (170 aa) |
| | SLC26A3-2 | Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | NFYB | Nuclear transcription factor Y subunit beta. (207 aa) |
| | SLC25A4 | Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa) |
| | TBPL1 | TATA-box binding protein like 1. (186 aa) |
| | CNRIP1 | Uncharacterized protein. (324 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (521 aa) |
| | VDAC1 | Voltage dependent anion channel 1. (283 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | MSX2 | Msh homeobox 2. (267 aa) |
| | ITGB2 | Integrin beta. (867 aa) |
| | LOC101082653 | Ig-like domain-containing protein. (276 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | LCK | Tyrosine-protein kinase. (520 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (292 aa) |
| | CDKN2B | ANK_REP_REGION domain-containing protein. (159 aa) |
| | PRKACB | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa) |
| | CANX | Calnexin. (637 aa) |
| | LOC101084962 | Ig-like domain-containing protein. (253 aa) |
| | LOC101090265 | Ig-like domain-containing protein. (263 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (523 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa) |
| | ANAPC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (812 aa) |
| | PIK3R2 | Phosphoinositide-3-kinase regulatory subunit 2. (726 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (760 aa) |
| | LOC111558970 | Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa) |
| | FLAI-K | Ig-like domain-containing protein; Belongs to the MHC class I family. (406 aa) |
| | LOC101082906 | Ig-like domain-containing protein. (282 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (916 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (439 aa) |
| | ANAPC10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (252 aa) |
| | FOS | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | LOC101090771 | Ig-like domain-containing protein; Belongs to the MHC class II family. (257 aa) |
| | ZFP36 | ZFP36 ring finger protein. (513 aa) |
| | CHEK2 | Checkpoint kinase 2. (569 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (555 aa) |
| | SLC25A6 | Solute carrier family 25 member 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (318 aa) |
| | MSX1 | Msh homeobox 1. (303 aa) |
| | IL2RG | Fibronectin type-III domain-containing protein. (390 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (930 aa) |
| | DLG1 | Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa) |
| | TSPO | Uncharacterized protein. (257 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (312 aa) |
| | LOC111560444 | Ig-like domain-containing protein; Belongs to the MHC class II family. (250 aa) |
| | LOC111556177 | Ig-like domain-containing protein; Belongs to the MHC class I family. (499 aa) |
| | SLC2A1 | Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (508 aa) |
| | LOC101084108 | Ig-like domain-containing protein; Belongs to the MHC class II family. (344 aa) |
| | TRRAP | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3872 aa) |
| | CDC27 | Cell division cycle 27. (839 aa) |
| | NFATC1 | Nuclear factor of activated T cells 1. (1085 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (428 aa) |
| | LOC101094232 | Ig-like domain-containing protein; Belongs to the MHC class I family. (461 aa) |
| | STAT5A | Signal transducer and activator of transcription. (794 aa) |
| | ADCY2 | Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1135 aa) |
| | PTTG1 | Uncharacterized protein. (213 aa) |
| | CREB3 | cAMP responsive element binding protein 3. (399 aa) |
| | ADCY1 | Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1148 aa) |
| | VDAC3 | Voltage dependent anion channel 3. (315 aa) |
| | ETS1 | ETS proto-oncogene 1, transcription factor. (503 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (721 aa) |
| | ELK1 | ETS transcription factor ELK1. (487 aa) |
| | LOC111556169 | Ig-like domain-containing protein. (276 aa) |
| | CREB3L2 | cAMP responsive element binding protein 3 like 2. (536 aa) |
| | BCL2L1 | BCL2 like 1. (271 aa) |
| | LOC111559549 | Ig-like domain-containing protein. (247 aa) |
| | ADCY5 | Adenylate cyclase 5; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1329 aa) |
| | LOC111560443 | Ig-like domain-containing protein; Belongs to the MHC class II family. (322 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (571 aa) |
| | CRTC1 | CREB regulated transcription coactivator 1. (654 aa) |
| | TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1302 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (774 aa) |
| | ITGAL | Integrin subunit alpha L; Belongs to the integrin alpha chain family. (1290 aa) |
| | E2F3 | E2F transcription factor 3. (523 aa) |
