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| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa) |
| | CALR | Calreticulin. (417 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa) |
| | STING1 | Stimulator of interferon genes. (377 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (463 aa) |
| | PAK1 | Non-specific serine/threonine protein kinase. (544 aa) |
| | AP1M2 | AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (425 aa) |
| | CD4 | CD4 molecule. (487 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa) |
| | IFNB1 | Interferon beta; Has antiviral, antibacterial and anticancer activities. (186 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (342 aa) |
| | IRF3 | Interferon regulatory factor 3. (420 aa) |
| | CALML6 | Calmodulin like 6. (180 aa) |
| | CALML4 | Calmodulin like 4. (196 aa) |
| | PDIA3 | Protein disulfide-isomerase. (505 aa) |
| | NFKBIA | NFKB inhibitor alpha. (314 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (444 aa) |
| | GNAI2 | G protein subunit alpha i2. (436 aa) |
| | GNAI1 | G protein subunit alpha i1. (354 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (989 aa) |
| | CFL2 | Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa) |
| | CCNB2 | Cyclin B2; Belongs to the cyclin family. (397 aa) |
| | LOC101083591 | Uncharacterized protein. (750 aa) |
| | GNG13 | G protein subunit gamma 13. (67 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (724 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | CD3D | CD3d molecule. (170 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | TAB1 | TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa) |
| | B2M | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (118 aa) |
| | GNB3 | G protein subunit beta 3. (339 aa) |
| | CUL5 | Cullin-5; Belongs to the cullin family. (780 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (627 aa) |
| | CFL1 | ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (166 aa) |
| | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa) |
| | MAP2K2 | Protein kinase domain-containing protein. (549 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (761 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) |
| | CDK1 | Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | WEE2 | Wee1-like protein kinase. (568 aa) |
| | LOC105260551 | Ig-like domain-containing protein; Belongs to the MHC class I family. (438 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa) |
| | KRAS | Uncharacterized protein. (380 aa) |
| | CALM2 | Calmodulin 2; Belongs to the calmodulin family. (149 aa) |
| | PAK2 | Non-specific serine/threonine protein kinase. (524 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | PAK4 | Non-specific serine/threonine protein kinase. (592 aa) |
| | GNB1 | G protein subunit beta 1. (340 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (451 aa) |
| | GNGT1 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa) |
| | IRAK4 | Interleukin 1 receptor associated kinase 4. (492 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1032 aa) |
| | AP1B1 | AP complex subunit beta. (949 aa) |
| | LOC101088440 | Uncharacterized protein. (183 aa) |
| | TLR2 | Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa) |
| | JUN | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa) |
| | GNB2 | G protein subunit beta 2. (340 aa) |
| | GNG14 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1075 aa) |
| | LOC101100947 | Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa) |
| | RBX1 | Ring-box 1. (108 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (829 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | GNAQ | G protein subunit alpha q. (359 aa) |
| | DDB1 | Damage specific DNA binding protein 1. (1140 aa) |
| | TCEB2 | Transcription elongation factor B polypeptide 2. (118 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (525 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa) |
| | LOC101099296 | Ig-like domain-containing protein; Belongs to the MHC class I family. (357 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa) |
| | DCAF1 | DDB1 and CUL4 associated factor 1. (1507 aa) |
| | FAS | Uncharacterized protein. (314 aa) |
| | GNB4 | G protein subunit beta 4. (340 aa) |
| | CUL4B | Cullin 4B; Belongs to the cullin family. (911 aa) |
| | GNG11 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa) |
| | GNGT2 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | CALML3 | Calmodulin like 3; Belongs to the calmodulin family. (149 aa) |
| | GNAI3 | G protein subunit alpha i3. (354 aa) |
| | LOC101080790 | MHC_I-like_Ag-recog domain-containing protein. (216 aa) |
| | BST2 | Uncharacterized protein. (202 aa) |
| | TRAF5 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa) |
| | LOC101097703 | EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa) |
| | AP1G2 | AP-1 complex subunit gamma. (908 aa) |
| | ELOC | Transcription elongation factor B polypeptide 1; Belongs to the SKP1 family. (112 aa) |
| | LOC101098462 | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (115 aa) |
| | PAK6 | Non-specific serine/threonine protein kinase. (681 aa) |
| | PAK5 | Non-specific serine/threonine protein kinase. (725 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (367 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | IFNA1 | Interferon alpha; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (194 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) |
| | GNG3 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa) |
| | PTK2 | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1112 aa) |
| | AP1G1 | AP-1 complex subunit gamma. (829 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | LIMK1 | LIM domain kinase 1. (763 aa) |
| | LOC101089770 | Uncharacterized protein. (715 aa) |
| | CNRIP1 | Uncharacterized protein. (324 aa) |
| | AP1S1 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (521 aa) |
| | CCNB3 | Uncharacterized protein; Belongs to the cyclin family. (285 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | CCNB1 | Cyclin B1; Belongs to the cyclin family. (600 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | IFNA13 | Uncharacterized protein. (193 aa) |
| | GNG5 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | ELOB | Elongin B. (202 aa) |
| | BTRC | Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa) |
| | PPP3CC | Serine/threonine-protein phosphatase. (523 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1318 aa) |
| | GNA11 | G protein subunit alpha 11. (359 aa) |
| | LOC111556311 | Uncharacterized protein. (857 aa) |
| | PIK3R2 | Phosphoinositide-3-kinase regulatory subunit 2. (726 aa) |
| | ENSFCAP00000043586 | Uncharacterized protein. (261 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (760 aa) |
| | FLAI-K | Ig-like domain-containing protein; Belongs to the MHC class I family. (406 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (215 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (304 aa) |
| | CGAS | Cyclic GMP-AMP synthase. (514 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (916 aa) |
| | TRADD | TNFRSF1A associated via death domain. (311 aa) |
| | FOS | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (435 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | GNG12 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa) |
| | AP1S2 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa) |
| | BAD | BCL2 associated agonist of cell death. (273 aa) |
| | PAK3 | P21 (RAC1) activated kinase 3. (589 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (555 aa) |
| | GNG8 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa) |
| | LOC101091023 | Ig-like domain-containing protein. (452 aa) |
| | FBXW11 | F-box and WD repeat domain containing 11. (563 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (930 aa) |
| | GNG10 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa) |
| | LOC111556177 | Ig-like domain-containing protein; Belongs to the MHC class I family. (499 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | CCR5 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (352 aa) |
| | NFATC1 | Nuclear factor of activated T cells 1. (1085 aa) |
| | LOC101094232 | Ig-like domain-containing protein; Belongs to the MHC class I family. (461 aa) |
| | RPS6KB2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa) |
| | CASP8 | Caspase 8; Belongs to the peptidase C14A family. (479 aa) |
| | PLCG1 | Phosphoinositide phospholipase C. (1391 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (205 aa) |
| | RAC2 | Rac family small GTPase 2. (234 aa) |
| | TAPBP | Ig-like domain-containing protein. (452 aa) |
| | WEE1 | WEE1 G2 checkpoint kinase. (664 aa) |
| | LIMK2 | LIM domain kinase 2. (711 aa) |
| | BCL2L1 | BCL2 like 1. (271 aa) |
| | LOC111559549 | Ig-like domain-containing protein. (247 aa) |
| | GNG2 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (152 aa) |
| | GNB5 | G protein subunit beta 5. (403 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (571 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (383 aa) |
| | SKP1 | Uncharacterized protein; Belongs to the SKP1 family. (168 aa) |
| | CXCR4 | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (400 aa) |
| | CHUK | Component of inhibitor of nuclear factor kappa B kinase complex. (774 aa) |
| | GNG4 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (250 aa) |
| | GNAO1 | G protein subunit alpha o1. (370 aa) |
| | CD247 | CD247 molecule. (250 aa) |
| | BCL2 | BCL2 apoptosis regulator. (237 aa) |
| | AP1M1 | AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (470 aa) |
