STRINGSTRING
BAX BAX TRAF2 TRAF2 SCRIB SCRIB NFKB2 NFKB2 CCNE1 CCNE1 SNW1 SNW1 JAK1 JAK1 KAT2A KAT2A STAT5B STAT5B STAT3 STAT3 CCR8 CCR8 CCR4 CCR4 HRAS HRAS GTF2H3 GTF2H3 KAT2B KAT2B CCNA1 CCNA1 EP300 EP300 SCIN SCIN VAC14 VAC14 MAD1L1 MAD1L1 EGR3 EGR3 GTF2B GTF2B IRF3 IRF3 CREBBP CREBBP EIF2AK2 EIF2AK2 NFKBIA NFKBIA CHD4 CHD4 HDAC3 HDAC3 TBP TBP GTF2H1 GTF2H1 JAK3 JAK3 NFKB1 NFKB1 MRPS18B MRPS18B ATP6V0D2 ATP6V0D2 REL REL LTBR LTBR EGR2 EGR2 ATF4 ATF4 H2BC18 H2BC18 IL6ST IL6ST PIK3R1 PIK3R1 YWHAB YWHAB MAPKAPK2 MAPKAPK2 CREB3L3 CREB3L3 SYK SYK H2BC1 H2BC1 HNRNPK HNRNPK CDK1 CDK1 CHEK1 CHEK1 IRF9 IRF9 ATF6B ATF6B LOC105260551 LOC105260551 GTF2H4 GTF2H4 CREB3L1 CREB3L1 KRAS KRAS LOC101081229 LOC101081229 RBL1 RBL1 GTF2E1 GTF2E1 RHOA RHOA CDK4 CDK4 YWHAZ YWHAZ PRKACA PRKACA DDX3X DDX3X CCR3 CCR3 CCNA2 CCNA2 SRF SRF LOC101096314 LOC101096314 H2BU1 H2BU1 GTF2A1L GTF2A1L CDKN1A CDKN1A IKBKG IKBKG JUN JUN LOC101088423 LOC101088423 CCNE2 CCNE2 GTF2E2 GTF2E2 LOC101092488 LOC101092488 LYN LYN ATF2 ATF2 RBPJ RBPJ PIK3CD PIK3CD UBE3A UBE3A GRB2 GRB2 CDC42-2 CDC42-2 RB1 RB1 DDB1 DDB1 MDM2 MDM2 MAPK1 MAPK1 LOC101099296 LOC101099296 ACTN4 ACTN4 PIK3CB PIK3CB LOC101080790 LOC101080790 TRAF5 TRAF5 ENSFCAP00000028809 ENSFCAP00000028809 YWHAG YWHAG SND1 SND1 HPN HPN RASA2 RASA2 HDAC11 HDAC11 CASP3 CASP3 CREB5 CREB5 CDC20 CDC20 HDAC1 HDAC1 NRAS NRAS MAPK3 MAPK3 USP7 USP7 HDAC2 HDAC2 HDAC9 HDAC9 TBPL1 TBPL1 TRAF3 TRAF3 PSMC1 PSMC1 HDAC4 HDAC4 PIK3CA PIK3CA GTF2A1 GTF2A1 RBL2 RBL2 CCND3 CCND3 CDKN2B CDKN2B DNAJA3 DNAJA3 PRKACB PRKACB LOC101082235 LOC101082235 SRC SRC CCND2 CCND2 ENSFCAP00000042498 ENSFCAP00000042498 PIK3R2 PIK3R2 RBPJL RBPJL CDKN1B CDKN1B FLAI-K FLAI-K HDAC6 HDAC6 TRADD TRADD HDAC7 HDAC7 ATP6V0D1 ATP6V0D1 IRF7 IRF7 PIK3R3 PIK3R3 BAD BAD YWHAH YWHAH RELA RELA YWHAE YWHAE GTF2A2 GTF2A2 CDK6 CDK6 PMAIP1 PMAIP1 LOC101086971 LOC101086971 H2BC3 H2BC3 DLG1 DLG1 CCND1 CCND1 LOC111556177 LOC111556177 TRAF1 TRAF1 UBR4 UBR4 ACTN1 ACTN1 H2BC5 H2BC5 GSN GSN CCR5 CCR5 POLB POLB LOC101094232 LOC101094232 CASP8 CASP8 STAT5A STAT5A CREB3 CREB3 HDAC10 HDAC10 VDAC3 VDAC3 SP100 SP100 CREB3L2 CREB3L2 YWHAQ YWHAQ SKP2 SKP2 H2BE1 H2BE1 LOC101094730 LOC101094730
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BAXBCL2 associated X, apoptosis regulator. (192 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
SCRIBScribble planar cell polarity protein. (1637 aa)
NFKB2Nuclear factor kappa B subunit 2. (921 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
SNW1SNW domain containing 1. (570 aa)
JAK1Tyrosine-protein kinase. (1157 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (836 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CCR8C-C motif chemokine receptor 8; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
GTF2H3General transcription factor IIH subunit 3. (309 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (834 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
EP300E1A binding protein p300. (2425 aa)
SCINScinderin. (715 aa)
VAC14VAC14 component of PIKFYVE complex. (783 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (916 aa)
EGR3Early growth response 3. (392 aa)
GTF2BGeneral transcription factor IIB. (285 aa)
IRF3Interferon regulatory factor 3. (420 aa)
CREBBPCREB binding protein. (2444 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (541 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
CHD4Uncharacterized protein. (1912 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
TBPTATA-box binding protein. (327 aa)
GTF2H1General transcription factor IIH subunit 1. (548 aa)
JAK3Tyrosine-protein kinase. (1232 aa)
NFKB1Nuclear factor kappa B subunit 1. (989 aa)
MRPS18BMitochondrial ribosomal protein S18B. (334 aa)
ATP6V0D2V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
RELREL proto-oncogene, NF-kB subunit. (583 aa)
LTBRLymphotoxin beta receptor. (433 aa)
EGR2Early growth response 2. (541 aa)
ATF4Activating transcription factor 4. (352 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (132 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
MAPKAPK2MAPK activated protein kinase 2. (409 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (448 aa)
SYKSpleen associated tyrosine kinase. (636 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
HNRNPKHeterogeneous nuclear ribonucleoprotein K. (464 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
IRF9Interferon regulatory factor 9. (411 aa)
ATF6BActivating transcription factor 6 beta. (628 aa)
LOC105260551Ig-like domain-containing protein; Belongs to the MHC class I family. (438 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (463 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
KRASUncharacterized protein. (380 aa)
LOC101081229Pyruvate kinase; Belongs to the pyruvate kinase family. (353 aa)
RBL1RB transcriptional corepressor like 1. (1068 aa)
GTF2E1General transcription factor IIE subunit 1. (438 aa)
RHOARas homolog family member A. (193 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (245 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (662 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (361 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
SRFSerum response factor. (512 aa)
LOC101096314Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
GTF2A1LGeneral transcription factor IIA subunit 1 like. (477 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
LOC101088423Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (406 aa)
GTF2E2Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (291 aa)
LOC101092488Histone domain-containing protein; Belongs to the histone H2B family. (127 aa)
LYNTyrosine-protein kinase. (526 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (500 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (834 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CDC42-2Uncharacterized protein. (191 aa)
RB1RB transcriptional corepressor 1. (930 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
LOC101099296Ig-like domain-containing protein; Belongs to the MHC class I family. (357 aa)
ACTN4Actinin alpha 4. (933 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
LOC101080790MHC_I-like_Ag-recog domain-containing protein. (216 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
ENSFCAP00000028809Histone H2B; Belongs to the histone H2B family. (67 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (289 aa)
SND1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (933 aa)
HPNHepsin; Belongs to the peptidase S1 family. (571 aa)
RASA2RAS p21 protein activator 2. (854 aa)
HDAC11Histone deacetylase 11. (357 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
CREB5cAMP responsive element binding protein 5. (523 aa)
CDC20Cell division cycle 20. (499 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (498 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1107 aa)
HDAC2Histone deacetylase 2. (602 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1068 aa)
TBPL1TATA-box binding protein like 1. (186 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
PSMC1AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1083 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GTF2A1General transcription factor IIA subunit 1. (376 aa)
RBL2RB transcriptional corepressor like 2. (1139 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
CDKN2BANK_REP_REGION domain-containing protein. (159 aa)
DNAJA3DnaJ heat shock protein family (Hsp40) member A3. (478 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
LOC101082235Histone H2B; Belongs to the histone H2B family. (126 aa)
SRCTyrosine-protein kinase. (678 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
ENSFCAP00000042498Histone domain-containing protein; Belongs to the histone H2B family. (118 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
RBPJLRecombination signal binding protein for immunoglobulin kappa J region like. (597 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa)
FLAI-KIg-like domain-containing protein; Belongs to the MHC class I family. (406 aa)
HDAC6Histone deacetylase 6. (1178 aa)
TRADDTNFRSF1A associated via death domain. (311 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1070 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
IRF7Interferon regulatory factor 7. (512 aa)
PIK3R3Uncharacterized protein. (461 aa)
BADBCL2 associated agonist of cell death. (273 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta. (69 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
GTF2A2Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (109 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (338 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
LOC101086971Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
LOC111556177Ig-like domain-containing protein; Belongs to the MHC class I family. (499 aa)
TRAF1TNF receptor-associated factor. (433 aa)
UBR4Ubiquitin protein ligase E3 component n-recognin 4. (5292 aa)
ACTN1Actinin alpha 1. (927 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
GSNGelsolin. (815 aa)
CCR5G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (352 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (428 aa)
LOC101094232Ig-like domain-containing protein; Belongs to the MHC class I family. (461 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (479 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
CREB3cAMP responsive element binding protein 3. (399 aa)
HDAC10Histone deacetylase 10. (546 aa)
VDAC3Voltage dependent anion channel 3. (315 aa)
SP100SP100 nuclear antigen. (826 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (536 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (301 aa)
SKP2S-phase kinase associated protein 2. (451 aa)
H2BE1Histone H2B; Belongs to the histone H2B family. (122 aa)
LOC101094730General transcription factor IIH subunit. (395 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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