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| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | FLNC | Filamin C. (2719 aa) |
| | HBEGF | Heparin binding EGF like growth factor. (305 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa) |
| | NANOG | Nanog homeobox. (311 aa) |
| | WNT8A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa) |
| | LOC101087880 | Uncharacterized protein; Belongs to the peptidase C1 family. (333 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (558 aa) |
| | STAT3 | Signal transducer and activator of transcription. (770 aa) |
| | TIAM1 | T cell lymphoma invasion and metastasis 1. (1591 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2757 aa) |
| | RPS6 | Ribosomal protein S6. (315 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | HIF1A | Hypoxia inducible factor 1 subunit alpha. (825 aa) |
| | CTNNB1 | Catenin beta 1. (783 aa) |
| | DDX5 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | PAK1 | Non-specific serine/threonine protein kinase. (544 aa) |
| | PTPN6 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (615 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa) |
| | COL1A1 | Collagen type I alpha 1 chain. (1461 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | FZD6 | Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa) |
| | VAV1 | Vav guanine nucleotide exchange factor 1. (846 aa) |
| | PLAUR | Plasminogen activator, urokinase receptor. (335 aa) |
| | SDC1 | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa) |
| | ANK2 | Uncharacterized protein. (1871 aa) |
| | TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) |
| | PPP1R12C | Protein phosphatase 1 regulatory subunit. (773 aa) |
| | PLCE1 | Phosphoinositide phospholipase C. (2301 aa) |
| | HOXD10 | Homeobox D10. (410 aa) |
| | ACTG1 | Actin gamma 1. (375 aa) |
| | ARHGEF1 | Rho guanine nucleotide exchange factor 1. (1069 aa) |
| | VTN | SMB domain-containing protein. (468 aa) |
| | FN1 | Fibronectin 1. (2475 aa) |
| | RRAS2 | Uncharacterized protein. (204 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1514 aa) |
| | ITGA5 | Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1104 aa) |
| | SLC9A1 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (759 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | PPP1CC | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa) |
| | THBS1 | Thrombospondin 1. (1170 aa) |
| | VAV2 | Vav guanine nucleotide exchange factor 2. (878 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | PDCD4 | Programmed cell death 4. (469 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (364 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa) |
| | ITGA2 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1177 aa) |
| | FZD9 | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (804 aa) |
| | ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa) |
| | MSN | Moesin. (577 aa) |
| | MMP9 | Matrix metallopeptidase 9. (705 aa) |
| | MAP2K2 | Protein kinase domain-containing protein. (549 aa) |
| | ERBB3 | ERBB3. (1339 aa) |
| | HCLS1 | Hematopoietic cell-specific Lyn substrate 1. (494 aa) |
| | LOC101101202 | Uncharacterized protein; Belongs to the peptidase C1 family. (305 aa) |
| | KRAS | Uncharacterized protein. (380 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1367 aa) |
| | PPP1CA | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa) |
| | IHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa) |
| | CBL | Cbl proto-oncogene. (902 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | LOC101084379 | Homeobox domain-containing protein. (290 aa) |
| | COL1A2 | Collagen type I alpha 2 chain. (1367 aa) |
| | PRKACA | Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (351 aa) |
| | PDP | Cathepsin L1; Thiol protease important for the overall degradation of proteins in lysosomes (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). Belongs to the peptidase C1 family. (332 aa) |
| | CAV2 | Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] (262 aa) |
| | PPP1R12A | Protein phosphatase 1 regulatory subunit. (1029 aa) |
| | WNT7B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | TLR2 | Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa) |
| | DCN | Decorin; May affect the rate of fibrils formation. (360 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | ESR1 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa) |
| | FZD2 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa) |
| | RRAS | RAS related. (218 aa) |
| | FZD1 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (652 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | SDC4 | Syndecan 4. (201 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (217 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | WNT16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (475 aa) |
| | CDC42-2 | Uncharacterized protein. (191 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | LOC105259631 | Uncharacterized protein; Belongs to the peptidase C1 family. (259 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa) |
| | ANK3 | Ankyrin 3. (4374 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa) |
| | FAS | Uncharacterized protein. (314 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1543 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | ANK1 | Ankyrin 1. (1896 aa) |
| | GPC1 | Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (557 aa) |
| | TWIST1 | Twist family bHLH transcription factor 1. (200 aa) |
| | FZD7 | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa) |
| | WNT2 | Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa) |
| | TIMP3 | TIMP metallopeptidase inhibitor 3. (211 aa) |
| | PTPN11 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa) |
| | TWIST2 | Twist family bHLH transcription factor 2. (160 aa) |
| | CAV3 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (367 aa) |
| | LOC111559123 | Uncharacterized protein; Belongs to the peptidase C1 family. (323 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa) |
| | ITGB1 | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | RDX | Radixin. (604 aa) |
| | FGFR1 | Fibroblast growth factor receptor. (852 aa) |
| | FZD10 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T- cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis. [FasL intr [...] (280 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (784 aa) |
| | HGF | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). (728 aa) |
| | PTK2 | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1112 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | ITGB5 | Integrin beta; Belongs to the integrin beta chain family. (800 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | IQGAP1 | IQ motif containing GTPase activating protein 1. (1657 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | CTSV | Cathepsin V; Belongs to the peptidase C1 family. (333 aa) |
| | FLNB | Filamin B. (2633 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | PPP1CB | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (333 aa) |
| | LOC101082891 | Uncharacterized protein; Belongs to the peptidase C1 family. (328 aa) |
| | FLNA | Filamin A. (2808 aa) |
| | MRAS | Muscle RAS oncogene homolog. (254 aa) |
| | FRS2 | Fibroblast growth factor receptor substrate 2. (543 aa) |
| | MMP2 | Matrix metallopeptidase 2. (661 aa) |
| | WNT10A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (416 aa) |
| | PRKACB | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa) |
| | TFAP4 | Transcription factor AP-4. (337 aa) |
| | GPC3 | Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa) |
| | SRC | Tyrosine-protein kinase. (678 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1209 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | IGF1 | Insulin like growth factor 1. (195 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1318 aa) |
| | ERBB4 | Receptor protein-tyrosine kinase. (1308 aa) |
| | ARAF | A-Raf proto-oncogene, serine/threonine kinase. (659 aa) |
| | PIK3R2 | Phosphoinositide-3-kinase regulatory subunit 2. (726 aa) |
| | CAMK2B | Calcium/calmodulin dependent protein kinase II beta. (748 aa) |
| | PTCH1 | Patched 1. (1451 aa) |
| | PLAU | Plasminogen activator, urokinase. (516 aa) |
| | HPSE2 | Heparanase 2 (inactive). (592 aa) |
| | HSPB2 | SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (182 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (439 aa) |
| | WNT2B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa) |
| | EIF4B | Eukaryotic translation initiation factor 4B. (616 aa) |
| | VAV3 | Vav guanine nucleotide exchange factor 3. (875 aa) |
| | WNT9A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | WNT7A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | WNT6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | WNT4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | HPSE | Heparanase. (543 aa) |
| | DROSHA | Drosha ribonuclease III. (1374 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa) |
| | ITGAV | Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (312 aa) |
| | FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (590 aa) |
| | RPS6KB2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa) |
| | PLCG1 | Phosphoinositide phospholipase C. (1391 aa) |
| | EZR | Ezrin. (639 aa) |
| | SDC2 | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (210 aa) |
| | WNT5B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (443 aa) |
| | RPS14 | Calcium/calmodulin dependent protein kinase II alpha. (566 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog. (721 aa) |
| | ELK1 | ETS transcription factor ELK1. (487 aa) |
| | ROCK2 | Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1471 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (571 aa) |
| | SMO | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (795 aa) |
| | MET | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1382 aa) |
| | CAMK2D | Calcium/calmodulin dependent protein kinase II delta. (544 aa) |
| | CD63 | CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal tr [...] (249 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (556 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (457 aa) |
| | HSPG2 | Heparan sulfate proteoglycan 2. (4385 aa) |
