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| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa) |
| | NOTCH3 | Notch receptor 3. (2323 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase. (798 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | STAT3 | Signal transducer and activator of transcription. (770 aa) |
| | CYP24A1 | Cytochrome P450 family 24 subfamily A member 1. (492 aa) |
| | IGF2BP1 | Insulin like growth factor 2 mRNA binding protein 1. (577 aa) |
| | TRIM71 | Tripartite motif containing 71. (874 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | PDGFRB | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1131 aa) |
| | DNMT3A | DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1054 aa) |
| | TNC | Tenascin C. (2200 aa) |
| | EP300 | E1A binding protein p300. (2425 aa) |
| | E2F1 | E2F transcription factor 1. (436 aa) |
| | ABL1 | Tyrosine-protein kinase. (1150 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (342 aa) |
| | CREBBP | CREB binding protein. (2444 aa) |
| | HOXD10 | Homeobox D10. (410 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (989 aa) |
| | SPRY2 | Sprouty RTK signaling antagonist 2. (315 aa) |
| | SERPINB5 | Serpin family B member 5; Belongs to the serpin family. (379 aa) |
| | EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (460 aa) |
| | CDC25A | Cell division cycle 25A. (524 aa) |
| | MAPK7 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (804 aa) |
| | FSCN1 | Fascin actin-bundling protein 1. (518 aa) |
| | PDGFRA | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa) |
| | ABCC1 | ATP binding cassette subfamily C member 1. (1486 aa) |
| | NOTCH2 | Notch receptor 2. (2493 aa) |
| | ITGA5 | Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1104 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | THBS1 | Thrombospondin 1. (1170 aa) |
| | E2F2 | E2F transcription factor 2. (442 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | PDCD4 | Programmed cell death 4. (469 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa) |
| | GLS2 | Glutaminase 2. (602 aa) |
| | RECK | Reversion inducing cysteine rich protein with kazal motifs. (971 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1872 aa) |
| | MMP9 | Matrix metallopeptidase 9. (705 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa) |
| | MAP2K2 | Protein kinase domain-containing protein. (549 aa) |
| | SLC7A1 | Solute carrier family 7 member 1. (803 aa) |
| | TNR | Tenascin R. (1358 aa) |
| | MDM4 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa) |
| | ERBB3 | ERBB3. (1339 aa) |
| | HNRNPK | Heterogeneous nuclear ribonucleoprotein K. (464 aa) |
| | ZEB2 | Zinc finger E-box binding homeobox 2. (1217 aa) |
| | PDGFB | Platelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa) |
| | KRAS | Uncharacterized protein. (380 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | PAK4 | Non-specific serine/threonine protein kinase. (592 aa) |
| | MMP16 | Matrix metallopeptidase 16. (607 aa) |
| | RHOA | Ras homolog family member A. (193 aa) |
| | IRS1 | Insulin receptor substrate 1. (1234 aa) |
| | UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | DDIT4 | DNA damage inducible transcript 4. (231 aa) |
| | CCNG1 | Cyclin G1; Belongs to the cyclin family. (295 aa) |
| | NOTCH1 | Notch receptor 1. (2543 aa) |
| | PTGS2 | Prostaglandin-endoperoxide synthase 2. (604 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa) |
| | PIM1 | Serine/threonine-protein kinase pim-1; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly th [...] (313 aa) |
| | CCNE2 | Cyclin E2; Belongs to the cyclin family. (406 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa) |
| | PDGFA | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity). (350 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (217 aa) |
| | CDCA5 | Cell division cycle associated 5. (252 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3064 aa) |
| | BMI1 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...] (326 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | SIRT1 | Sirtuin 1. (745 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | TIMP3 | TIMP metallopeptidase inhibitor 3. (211 aa) |
| | ZEB1 | Zinc finger E-box binding homeobox 1. (1125 aa) |
| | SHC4 | SHC adaptor protein 4. (630 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | RDX | Radixin. (604 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (498 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (784 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | GLS | Glutaminase. (672 aa) |
| | KIF23 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (990 aa) |
| | HDAC2 | Histone deacetylase 2. (602 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | HDAC4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1083 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | APC | APC regulator of WNT signaling pathway. (2874 aa) |
| | DICER1 | Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1924 aa) |
| | ELK4 | Solute carrier family 45 member 3. (564 aa) |
| | RASSF1 | Ras association domain family member 1. (344 aa) |
| | MARCKS | Myristoylated alanine rich protein kinase C substrate. (353 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1209 aa) |
| | APC2 | APC regulator of WNT signaling pathway 2. (2289 aa) |
| | RPTOR | Regulatory associated protein of MTOR complex 1. (1335 aa) |
| | HMGA2 | Uncharacterized protein. (109 aa) |
| | EFNA5 | Ephrin A5; Belongs to the ephrin family. (228 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1318 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (553 aa) |
| | EFNA4 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. (314 aa) |
| | PIK3R2 | Phosphoinositide-3-kinase regulatory subunit 2. (726 aa) |
| | FGFR3 | Fibroblast growth factor receptor. (805 aa) |
| | DNMT1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1710 aa) |
| | CDKN1B | Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (760 aa) |
| | PLAU | Plasminogen activator, urokinase. (516 aa) |
| | BCL2L2 | BCL2 like 2. (193 aa) |
| | CRK | CRK proto-oncogene, adaptor protein. (304 aa) |
| | ZFPM2 | Zinc finger protein, FOG family member 2. (1151 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (439 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | IRS2 | Insulin receptor substrate 2. (1335 aa) |
| | EFNA2 | Ephrin A2; Belongs to the ephrin family. (263 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (203 aa) |
| | DNMT3B | DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (856 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (338 aa) |
| | VIM | Vimentin; Belongs to the intermediate filament family. (466 aa) |
| | EFNA3 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. (237 aa) |
| | STMN1 | Stathmin; Belongs to the stathmin family. (149 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (312 aa) |
| | SOX4 | Transcription factor SOX. (459 aa) |
| | BMF | Bcl2 modifying factor. (287 aa) |
| | PLCG1 | Phosphoinositide phospholipase C. (1391 aa) |
| | EZR | Ezrin. (639 aa) |
| | ST14 | Suppression of tumorigenicity 14. (861 aa) |
| | ENSFCAP00000057780 | Uncharacterized protein. (585 aa) |
| | MET | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1382 aa) |
| | BCL2 | BCL2 apoptosis regulator. (237 aa) |
| | E2F3 | E2F transcription factor 3. (523 aa) |
