STRINGSTRING
MTOR MTOR BAX BAX JAK1 JAK1 STAT3 STAT3 MAPK10 MAPK10 AKT3 AKT3 ARHGEF6 ARHGEF6 AKT1 AKT1 E2F1 E2F1 TGFB1 TGFB1 NFKB1 NFKB1 PLD2 PLD2 PIK3R1 PIK3R1 E2F2 E2F2 BRAF BRAF GADD45B GADD45B TGFB3 TGFB3 KRAS KRAS CDK4 CDK4 CASP9 CASP9 RALA RALA RALB RALB BRCA2 BRCA2 CDKN1A CDKN1A IKBKG IKBKG RPS6KB1 RPS6KB1 MAP2K1 MAP2K1 PIK3CD PIK3CD CDC42-2 CDC42-2 RB1 RB1 MAPK1 MAPK1 PIK3CB PIK3CB POLK POLK SMAD4 SMAD4 RAF1 RAF1 MAPK3 MAPK3 PLD1 PLD1 PIK3CA PIK3CA MAPK8 MAPK8 TGFA TGFA EGFR EGFR ARAF ARAF RALGDS RALGDS PIK3R2 PIK3R2 IKBKB IKBKB PIK3R3 PIK3R3 BAD BAD GADD45G GADD45G MAPK9 MAPK9 TGFBR1 TGFBR1 RELA RELA CDK6 CDK6 STAT1 STAT1 CCND1 CCND1 RALBP1 RALBP1 RPS6KB2 RPS6KB2 RAC2 RAC2 SMAD2 SMAD2 RAD51 RAD51 BCL2L1 BCL2L1 AKT2 AKT2 EGF EGF CHUK CHUK E2F3 E2F3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
JAK1Tyrosine-protein kinase. (1157 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (775 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
E2F1E2F transcription factor 1. (436 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
NFKB1Nuclear factor kappa B subunit 1. (989 aa)
PLD2Phospholipase. (984 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
E2F2E2F transcription factor 2. (442 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (234 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
KRASUncharacterized protein. (380 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (451 aa)
RALARAS like proto-oncogene A. (206 aa)
RALBRAS like proto-oncogene B. (206 aa)
BRCA2Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...] (3375 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
CDC42-2Uncharacterized protein. (191 aa)
RB1RB transcriptional corepressor 1. (930 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
POLKDNA polymerase kappa. (863 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PLD1Phospholipase. (1074 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TGFATransforming growth factor alpha. (192 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (659 aa)
RALGDSUncharacterized protein. (885 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
PIK3R3Uncharacterized protein. (461 aa)
BADBCL2 associated agonist of cell death. (273 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (338 aa)
STAT1Signal transducer and activator of transcription. (885 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
RALBP1RalA binding protein 1. (659 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
RAC2Rac family small GTPase 2. (234 aa)
SMAD2Mothers against decapentaplegic homolog. (721 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (356 aa)
BCL2L1BCL2 like 1. (271 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
E2F3E2F transcription factor 3. (523 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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