STRINGSTRING
MTOR MTOR BAX BAX CAMK4 CAMK4 PRKCG PRKCG HRAS HRAS PDGFRB PDGFRB AKT3 AKT3 SHC3 SHC3 AKT1 AKT1 E2F1 E2F1 CALML6 CALML6 CALML4 CALML4 PDGFRA PDGFRA PIK3R1 PIK3R1 PRKCB PRKCB E2F2 E2F2 PRKCA PRKCA BRAF BRAF GADD45B GADD45B MAP2K2 MAP2K2 CAMK1 CAMK1 SHC2 SHC2 PDGFB PDGFB KRAS KRAS PTEN PTEN IGF1R IGF1R CALM2 CALM2 CDK4 CDK4 CDKN1A CDKN1A MAP2K1 MAP2K1 SOS1 SOS1 PDGFA PDGFA PIK3CD PIK3CD GRB2 GRB2 RB1 RB1 SOS2 SOS2 MDM2 MDM2 MAPK1 MAPK1 PIK3CB PIK3CB CALML3 CALML3 POLK POLK LOC101097703 LOC101097703 SHC4 SHC4 RAF1 RAF1 NRAS NRAS MAPK3 MAPK3 CAMK1G CAMK1G PIK3CA PIK3CA TGFA TGFA EGFR EGFR IGF1 IGF1 PLCG2 PLCG2 ARAF ARAF PIK3R2 PIK3R2 ENSFCAP00000043586 ENSFCAP00000043586 CAMK2B CAMK2B CAMK1D CAMK1D PIK3R3 PIK3R3 GADD45G GADD45G CDK6 CDK6 CCND1 CCND1 PLCG1 PLCG1 RPS14 RPS14 AKT2 AKT2 EGF EGF CAMK2D CAMK2D E2F3 E2F3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (638 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1131 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SHC3SHC adaptor protein 3. (587 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
E2F1E2F transcription factor 1. (436 aa)
CALML6Calmodulin like 6. (180 aa)
CALML4Calmodulin like 4. (196 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
E2F2E2F transcription factor 2. (442 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (234 aa)
MAP2K2Protein kinase domain-containing protein. (549 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (370 aa)
SHC2SHC adaptor protein 2. (583 aa)
PDGFBPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa)
KRASUncharacterized protein. (380 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
RB1RB transcriptional corepressor 1. (930 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
POLKDNA polymerase kappa. (863 aa)
LOC101097703EF-hand domain-containing protein; Belongs to the calmodulin family. (86 aa)
SHC4SHC adaptor protein 4. (630 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (494 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TGFATransforming growth factor alpha. (192 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
IGF1Insulin like growth factor 1. (195 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1318 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (659 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
ENSFCAP00000043586Uncharacterized protein. (261 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (748 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID. (392 aa)
PIK3R3Uncharacterized protein. (461 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (338 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
PLCG1Phosphoinositide phospholipase C. (1391 aa)
RPS14Calcium/calmodulin dependent protein kinase II alpha. (566 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (544 aa)
E2F3E2F transcription factor 3. (523 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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