STRINGSTRING
FGF6 FGF6 BAX BAX HRAS HRAS PDGFRB PDGFRB AKT3 AKT3 AKT1 AKT1 E2F1 E2F1 FGF21 FGF21 PDGFRA PDGFRA PIK3R1 PIK3R1 E2F2 E2F2 BRAF BRAF GADD45B GADD45B MAP2K2 MAP2K2 PDGFB PDGFB KRAS KRAS PTEN PTEN IGF1R IGF1R FGF16 FGF16 CDK4 CDK4 FGF7 FGF7 CDKN1A CDKN1A MAP2K1 MAP2K1 FGF9 FGF9 PDGFA PDGFA PIK3CD PIK3CD RB1 RB1 MDM2 MDM2 MAPK1 MAPK1 PIK3CB PIK3CB POLK POLK RAF1 RAF1 FGFR1 FGFR1 FGF10 FGF10 FGF4 FGF4 HGF HGF NRAS NRAS MAPK3 MAPK3 PIK3CA PIK3CA MITF MITF FGF19 FGF19 EGFR EGFR IGF1 IGF1 ARAF ARAF PIK3R2 PIK3R2 FGF20 FGF20 FGF5 FGF5 PIK3R3 PIK3R3 FGF3 FGF3 BAD BAD GADD45G GADD45G FGF18 FGF18 FGF23 FGF23 CDK6 CDK6 CDH1 CDH1 CCND1 CCND1 PDGFD PDGFD FGF17 FGF17 FGF22 FGF22 PDGFC PDGFC AKT2 AKT2 EGF EGF MET MET E2F3 E2F3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1131 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
E2F1E2F transcription factor 1. (436 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
E2F2E2F transcription factor 2. (442 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (234 aa)
MAP2K2Protein kinase domain-containing protein. (549 aa)
PDGFBPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa)
KRASUncharacterized protein. (380 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
RB1RB transcriptional corepressor 1. (930 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
POLKDNA polymerase kappa. (863 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
FGFR1Fibroblast growth factor receptor. (852 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
HGFHepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity). (728 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MITFMelanocyte inducing transcription factor. (502 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
IGF1Insulin like growth factor 1. (195 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (659 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
FGF5Fibroblast growth factor 5. (279 aa)
PIK3R3Uncharacterized protein. (461 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (229 aa)
BADBCL2 associated agonist of cell death. (273 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (326 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (338 aa)
CDH1Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (881 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
PDGFDPlatelet derived growth factor D. (380 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (285 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (271 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1382 aa)
E2F3E2F transcription factor 3. (523 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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