STRINGSTRING
HBEGF HBEGF RPS6KA5 RPS6KA5 HRAS HRAS CXCL8 CXCL8 E2F1 E2F1 DAPK1 DAPK1 THBS1 THBS1 E2F2 E2F2 BRAF BRAF MMP9 MMP9 MAP2K2 MAP2K2 MMP1 MMP1 KRAS KRAS CDK4 CDK4 CDKN1A CDKN1A MAP2K1 MAP2K1 RB1 RB1 MDM2 MDM2 MAPK1 MAPK1 DAPK3 DAPK3 RAF1 RAF1 NRAS NRAS MAPK3 MAPK3 DAPK2 DAPK2 MMP2 MMP2 RASSF1 RASSF1 SRC SRC EGFR EGFR ARAF ARAF FGFR3 FGFR3 MYC MYC CDH1 CDH1 CCND1 CCND1 EGF EGF E2F3 E2F3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HBEGFHeparin binding EGF like growth factor. (305 aa)
RPS6KA5Ribosomal protein S6 kinase. (798 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity); Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
E2F1E2F transcription factor 1. (436 aa)
DAPK1Death associated protein kinase 1. (1429 aa)
THBS1Thrombospondin 1. (1170 aa)
E2F2E2F transcription factor 2. (442 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
MMP9Matrix metallopeptidase 9. (705 aa)
MAP2K2Protein kinase domain-containing protein. (549 aa)
MMP1Matrix metallopeptidase 1. (471 aa)
KRASUncharacterized protein. (380 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
RB1RB transcriptional corepressor 1. (930 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
DAPK3Death associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
DAPK2Death associated protein kinase 2; Belongs to the protein kinase superfamily. (488 aa)
MMP2Matrix metallopeptidase 2. (661 aa)
RASSF1Ras association domain family member 1. (344 aa)
SRCTyrosine-protein kinase. (678 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (659 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (439 aa)
CDH1Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (881 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa)
E2F3E2F transcription factor 3. (523 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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