(67 nodes) Chronic myeloid leukemia network (Felis catus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BAX	BCL2 associated X, apoptosis regulator. (192 aa)
	STAT5B	Signal transducer and activator of transcription. (786 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	SHC3	SHC adaptor protein 3. (587 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	E2F1	E2F transcription factor 1. (436 aa)
	ABL1	Tyrosine-protein kinase. (1150 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (342 aa)
	NFKBIA	NFKB inhibitor alpha. (314 aa)
	RUNX1	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (493 aa)
	GAB2	GRB2 associated binding protein 2. (678 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (989 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
	E2F2	E2F transcription factor 2. (442 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (804 aa)
	GADD45B	Growth arrest and DNA damage inducible beta. (234 aa)
	MAP2K2	Protein kinase domain-containing protein. (549 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	SHC2	SHC adaptor protein 2. (583 aa)
	KRAS	Uncharacterized protein. (380 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1282 aa)
	CBL	Cbl proto-oncogene. (902 aa)
	CDK4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	RB1	RB transcriptional corepressor 1. (930 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (712 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	POLK	DNA polymerase kappa. (863 aa)
	SHC4	SHC adaptor protein 4. (630 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (498 aa)
	MECOM	MDS1 and EVI1 complex locus. (1239 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
	HDAC2	Histone deacetylase 2. (602 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (659 aa)
	PIK3R2	Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
	CDKN1B	Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
	CRK	CRK proto-oncogene, adaptor protein. (304 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (439 aa)
	PIK3R3	Uncharacterized protein. (461 aa)
	BAD	BCL2 associated agonist of cell death. (273 aa)
	GADD45G	Growth arrest and DNA damage inducible gamma. (159 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (555 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (338 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (312 aa)
	CTBP2	C-terminal binding protein 2. (977 aa)
	STAT5A	Signal transducer and activator of transcription. (794 aa)
	BCL2L1	BCL2 like 1. (271 aa)
	AKT2	Non-specific serine/threonine protein kinase. (571 aa)
	CTBP1	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (467 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
	E2F3	E2F transcription factor 3. (523 aa)

Your Current Organism:

Felis catus

NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	BCR	ENSFCAP00000004739	ENSFCAP00000017023	Tyrosine-protein kinase.	BCR activator of RhoGEF and GTPase.	0.928
ABL1	CBL	ENSFCAP00000004739	ENSFCAP00000017530	Tyrosine-protein kinase.	Cbl proto-oncogene.	0.952
ABL1	CCND1	ENSFCAP00000004739	ENSFCAP00000051341	Tyrosine-protein kinase.	Cyclin D1; Belongs to the cyclin family.	0.406
ABL1	CDKN1A	ENSFCAP00000004739	ENSFCAP00000020450	Tyrosine-protein kinase.	Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...]	0.431
ABL1	CDKN1B	ENSFCAP00000004739	ENSFCAP00000044526	Tyrosine-protein kinase.	Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.	0.402
ABL1	CRK	ENSFCAP00000004739	ENSFCAP00000045425	Tyrosine-protein kinase.	CRK proto-oncogene, adaptor protein.	0.971
ABL1	CRKL	ENSFCAP00000004739	ENSFCAP00000005579	Tyrosine-protein kinase.	CRK like proto-oncogene, adaptor protein.	0.964
ABL1	GRB2	ENSFCAP00000004739	ENSFCAP00000023767	Tyrosine-protein kinase.	Growth factor receptor bound protein 2.	0.960
ABL1	KRAS	ENSFCAP00000004739	ENSFCAP00000016005	Tyrosine-protein kinase.	Uncharacterized protein.	0.428
ABL1	PIK3CA	ENSFCAP00000004739	ENSFCAP00000037527	Tyrosine-protein kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.462
ABL1	RB1	ENSFCAP00000004739	ENSFCAP00000024610	Tyrosine-protein kinase.	RB transcriptional corepressor 1.	0.935
ABL1	RUNX1	ENSFCAP00000004739	ENSFCAP00000006283	Tyrosine-protein kinase.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.623
ABL1	SHC2	ENSFCAP00000004739	ENSFCAP00000014316	Tyrosine-protein kinase.	SHC adaptor protein 2.	0.922
ABL1	SHC3	ENSFCAP00000004739	ENSFCAP00000003880	Tyrosine-protein kinase.	SHC adaptor protein 3.	0.927
ABL1	SHC4	ENSFCAP00000004739	ENSFCAP00000029642	Tyrosine-protein kinase.	SHC adaptor protein 4.	0.922
ABL1	STAT5A	ENSFCAP00000004739	ENSFCAP00000055307	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.922
ABL1	STAT5B	ENSFCAP00000004739	ENSFCAP00000001990	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.923
AKT1	AKT2	ENSFCAP00000004586	ENSFCAP00000059662	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.901
AKT1	AKT3	ENSFCAP00000004586	ENSFCAP00000003410	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.917
AKT1	BAD	ENSFCAP00000004586	ENSFCAP00000047559	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 associated agonist of cell death.	0.948