STRINGSTRING
BAX BAX TRAF2 TRAF2 CCNE1 CCNE1 ITGA2B ITGA2B AKT3 AKT3 TRAF4 TRAF4 LAMB1 LAMB1 LAMB4 LAMB4 ITGA3 ITGA3 AKT1 AKT1 E2F1 E2F1 LAMC3 LAMC3 NFKBIA NFKBIA NFKB1 NFKB1 LAMA1 LAMA1 FN1 FN1 LAMA3 LAMA3 LAMB2 LAMB2 RARB RARB LAMC2 LAMC2 RXRG RXRG PIK3R1 PIK3R1 E2F2 E2F2 XIAP XIAP ITGA2 ITGA2 GADD45B GADD45B BIRC3 BIRC3 COL4A1 COL4A1 PTEN PTEN CKS2 CKS2 CDK4 CDK4 CASP9 CASP9 LAMC1 LAMC1 PTGS2 PTGS2 CDKN1A CDKN1A IKBKG IKBKG CCNE2 CCNE2 LOC101100947 LOC101100947 PIK3CD PIK3CD RB1 RB1 LAMB3 LAMB3 FHIT FHIT CKS1B CKS1B PIK3CB PIK3CB POLK POLK TRAF5 TRAF5 ITGB1 ITGB1 CASP3 CASP3 PTK2 PTK2 TRAF3 TRAF3 ITGA6 ITGA6 PIK3CA PIK3CA NOS2 NOS2 CDKN2B CDKN2B COL4A3 COL4A3 PIK3R2 PIK3R2 LOC101085801 LOC101085801 COL4A6 COL4A6 CDKN1B CDKN1B IKBKB IKBKB MAX MAX MYC MYC PIK3R3 PIK3R3 APAF1 APAF1 COL4A5 COL4A5 GADD45G GADD45G TRAF6 TRAF6 RELA RELA RXRA RXRA CDK6 CDK6 ITGAV ITGAV CCND1 CCND1 TRAF1 TRAF1 COL4A2 COL4A2 LAMA2 LAMA2 LAMA4 LAMA4 ZBTB17 ZBTB17 BCL2L1 BCL2L1 AKT2 AKT2 SKP2 SKP2 CHUK CHUK BCL2 BCL2 E2F3 E2F3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BAXBCL2 associated X, apoptosis regulator. (192 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (410 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1086 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TRAF4TNF receptor-associated factor. (470 aa)
LAMB1Laminin subunit beta 1. (1786 aa)
LAMB4Laminin subunit beta 4. (1747 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
E2F1E2F transcription factor 1. (436 aa)
LAMC3Laminin subunit gamma 3. (1573 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
NFKB1Nuclear factor kappa B subunit 1. (989 aa)
LAMA1Laminin subunit alpha 1. (3080 aa)
FN1Fibronectin 1. (2475 aa)
LAMA3Laminin subunit alpha 3. (3332 aa)
LAMB2Laminin subunit beta 2. (1801 aa)
RARBRetinoic acid receptor beta. (448 aa)
LAMC2Laminin subunit gamma 2. (1191 aa)
RXRGRetinoid X receptor gamma. (463 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
E2F2E2F transcription factor 2. (442 aa)
XIAPX-linked inhibitor of apoptosis. (454 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1177 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (234 aa)
BIRC3Baculoviral IAP repeat containing 3. (624 aa)
COL4A1Collagen type IV alpha 1 chain. (1669 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (451 aa)
LAMC1Laminin subunit gamma 1. (1608 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
CDKN1ACyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (406 aa)
LOC101100947Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
RB1RB transcriptional corepressor 1. (930 aa)
LAMB3Laminin subunit beta 3. (1217 aa)
FHITBis(5'-adenosyl)-triphosphatase. (149 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
POLKDNA polymerase kappa. (863 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa)
CASP3Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. (302 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1112 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1165 aa)
CDKN2BANK_REP_REGION domain-containing protein. (159 aa)
COL4A3Collagen type IV alpha 3 chain. (1669 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
LOC101085801Uncharacterized protein. (467 aa)
COL4A6Collagen type IV alpha 6 chain. (1705 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. (198 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
MAXProtein max; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity (By similarity). Represses MYC transcriptional activity from E-box elements (By similarity). (411 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (439 aa)
PIK3R3Uncharacterized protein. (461 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1250 aa)
COL4A5Collagen type IV alpha 5 chain. (1689 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
RXRARetinoid X receptor alpha. (654 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (338 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (312 aa)
TRAF1TNF receptor-associated factor. (433 aa)
COL4A2Collagen type IV alpha 2 chain. (1854 aa)
LAMA2Laminin subunit alpha 2. (3125 aa)
LAMA4Laminin subunit alpha 4. (1856 aa)
ZBTB17Zinc finger and BTB domain containing 17. (811 aa)
BCL2L1BCL2 like 1. (271 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
SKP2S-phase kinase associated protein 2. (451 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
BCL2BCL2 apoptosis regulator. (237 aa)
E2F3E2F transcription factor 3. (523 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.