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| | LRP6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | FGF6 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | NOTCH3 | Notch receptor 3. (2323 aa) |
| | NFKB2 | Nuclear factor kappa B subunit 2. (921 aa) |
| | WNT8A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa) |
| | FLT4 | Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1405 aa) |
| | FRAT1 | Uncharacterized protein. (281 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | KIT | Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (979 aa) |
| | CTNNB1 | Catenin beta 1. (783 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | SHC3 | SHC adaptor protein 3. (587 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | E2F1 | E2F transcription factor 1. (436 aa) |
| | FZD6 | Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa) |
| | TNFSF11 | TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa) |
| | FGF21 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | DVL1 | Dishevelled segment polarity protein 1. (700 aa) |
| | DVL3 | Dishevelled segment polarity protein 3. (718 aa) |
| | NOTCH2 | Notch receptor 2. (2493 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (725 aa) |
| | E2F2 | E2F transcription factor 2. (442 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | FZD9 | Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (804 aa) |
| | GADD45B | Growth arrest and DNA damage inducible beta. (234 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1872 aa) |
| | MAP2K2 | Protein kinase domain-containing protein. (549 aa) |
| | DLL4 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa) |
| | NCOA3 | Nuclear receptor coactivator. (1412 aa) |
| | SHC2 | SHC adaptor protein 2. (583 aa) |
| | KRAS | Uncharacterized protein. (380 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1367 aa) |
| | SP1 | Sp1 transcription factor. (786 aa) |
| | FGF16 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | CDK4 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa) |
| | FGF7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa) |
| | HEY1 | Hes related family bHLH transcription factor with YRPW motif 1. (308 aa) |
| | BRCA2 | Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...] (3375 aa) |
| | WNT7B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | NOTCH1 | Notch receptor 1. (2543 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | ESR1 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa) |
| | CDKN1A | Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression (By similarity). Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1 (By similarity). At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity). Inhibits [...] (164 aa) |
| | FZD2 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa) |
| | JUN | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa) |
| | FZD1 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (652 aa) |
| | FZD3 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa) |
| | AXIN2 | Axin 2. (841 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (217 aa) |
| | WNT16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (475 aa) |
| | RB1 | RB transcriptional corepressor 1. (930 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | LRP5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1620 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa) |
| | JAG2 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1609 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | AXIN1 | Axin 1. (867 aa) |
| | POLK | DNA polymerase kappa. (863 aa) |
| | FZD7 | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa) |
| | WNT2 | Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa) |
| | SHC4 | SHC adaptor protein 4. (630 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa) |
| | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase. (668 aa) |
| | FGFR1 | Fibroblast growth factor receptor. (852 aa) |
| | FZD10 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa) |
| | FGF4 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | TCF7L1 | Transcription factor 7 like 1. (586 aa) |
| | DLL3 | Delta like canonical Notch ligand 3. (589 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | HEY2 | Hes related family bHLH transcription factor with YRPW motif 2. (337 aa) |
| | APC | APC regulator of WNT signaling pathway. (2874 aa) |
| | FGF19 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa) |
| | WNT10A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (416 aa) |
| | HES5 | Hes family bHLH transcription factor 5. (166 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1209 aa) |
| | APC2 | APC regulator of WNT signaling pathway 2. (2289 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | IGF1 | Insulin like growth factor 1. (195 aa) |
| | NCOA1 | Nuclear receptor coactivator. (1492 aa) |
| | ARAF | A-Raf proto-oncogene, serine/threonine kinase. (659 aa) |
| | ESR2 | Estrogen receptor 2. (574 aa) |
| | FRAT2 | FRAT regulator of WNT signaling pathway 2. (234 aa) |
| | PIK3R2 | Phosphoinositide-3-kinase regulatory subunit 2. (726 aa) |
| | GSK3B | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa) |
| | FGF20 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | FGF5 | Fibroblast growth factor 5. (279 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (439 aa) |
| | WNT2B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa) |
| | FOS | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa) |
| | WNT9A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | PIK3R3 | Uncharacterized protein. (461 aa) |
| | DVL2 | Dishevelled segment polarity protein 2. (735 aa) |
| | FGF3 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (229 aa) |
| | GADD45G | Growth arrest and DNA damage inducible gamma. (159 aa) |
| | WNT7A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | FGF18 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (326 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (415 aa) |
| | WNT6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa) |
| | FGF23 | Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (245 aa) |
| | WNT4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa) |
| | PGR | Progesterone receptor. (932 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (338 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (673 aa) |
| | HES1 | Hes family bHLH transcription factor 1. (280 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (312 aa) |
| | FZD5 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (590 aa) |
| | FGF17 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (285 aa) |
| | FGF22 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (271 aa) |
| | RPS6KB2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa) |
| | WNT5B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (443 aa) |
| | ENSFCAP00000057780 | Uncharacterized protein. (585 aa) |
| | JAG1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1287 aa) |
| | DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (731 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (571 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (457 aa) |
| | E2F3 | E2F transcription factor 3. (523 aa) |
