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MTOR MTOR PDHB PDHB HRAS HRAS HK3 HK3 KIT KIT PFKL PFKL HIF1A HIF1A PDGFRB PDGFRB AKT3 AKT3 IDH1 IDH1 FLT3 FLT3 HKDC1 HKDC1 HK1 HK1 AKT1 AKT1 SLC1A5 SLC1A5 HK2 HK2 PDHA2 PDHA2 PDGFRA PDGFRA PIK3R1 PIK3R1 GLS2 GLS2 SLC7A5 SLC7A5 PDHA1 PDHA1 RET RET SCO2 SCO2 PFKM PFKM MAP2K2 MAP2K2 GCK GCK NTRK3 NTRK3 KRAS KRAS PTEN PTEN LOC101081229 LOC101081229 PGAM2 PGAM2 IDH2 IDH2 MAP2K1 MAP2K1 PIK3CD PIK3CD PDK1 PDK1 MAPK1 MAPK1 PIK3CB PIK3CB ENSFCAP00000031759 ENSFCAP00000031759 RAF1 RAF1 FGFR1 FGFR1 NRAS NRAS MAPK3 MAPK3 GLS GLS PIK3CA PIK3CA PGAM1 PGAM1 EGFR EGFR LDHC LDHC LDHA LDHA PIK3R2 PIK3R2 FGFR3 FGFR3 MYC MYC PIK3R3 PIK3R3 NTRK1 NTRK1 LDHB LDHB TIGAR TIGAR SIRT6 SIRT6 SLC2A1 SLC2A1 PFKP PFKP SLC2A2 SLC2A2 SIRT3 SIRT3 AKT2 AKT2 FGFR2 FGFR2 MET MET SLC16A3 SLC16A3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
HK3Hexokinase 3. (924 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (979 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (825 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1131 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1022 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
HK1Hexokinase 1. (1056 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SLC1A5Amino acid transporter. (541 aa)
HK2Hexokinase 2. (917 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (391 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
GLS2Glutaminase 2. (602 aa)
SLC7A5Solute carrier family 7 member 5. (509 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (397 aa)
RETRet proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1138 aa)
SCO2SCO cytochrome c oxidase assembly protein 2. (266 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (859 aa)
MAP2K2Protein kinase domain-containing protein. (549 aa)
GCKPhosphotransferase. (466 aa)
NTRK3Tyrosine-protein kinase receptor. (863 aa)
KRASUncharacterized protein. (380 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
LOC101081229Pyruvate kinase; Belongs to the pyruvate kinase family. (353 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (451 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
PDK1Protein-serine/threonine kinase. (449 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
ENSFCAP00000031759PFK domain-containing protein. (208 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
FGFR1Fibroblast growth factor receptor. (852 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
GLSGlutaminase. (672 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (332 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (358 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
FGFR3Fibroblast growth factor receptor. (805 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (439 aa)
PIK3R3Uncharacterized protein. (461 aa)
NTRK1Tyrosine-protein kinase receptor. (770 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (428 aa)
SIRT6Sirtuin 6. (412 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (508 aa)
PFKPUncharacterized protein. (753 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (571 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (417 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1382 aa)
SLC16A3Solute carrier family 16 member 3. (542 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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