STRINGSTRING
MTOR MTOR SLC5A7 SLC5A7 PRKCG PRKCG PDPK1 PDPK1 MAPK10 MAPK10 SLC22A2 SLC22A2 HRAS HRAS HIF1A HIF1A PDGFRB PDGFRB AKT3 AKT3 AKT1 AKT1 PIP5K1A PIP5K1A LOC101083342 LOC101083342 WASF2 WASF2 PLD2 PLD2 PDGFRA PDGFRA WASF3 WASF3 EIF4EBP1 EIF4EBP1 PIK3R1 PIK3R1 PRKCB PRKCB PRKCA PRKCA DGKQ DGKQ RHEB RHEB MAP2K2 MAP2K2 DGKK DGKK PDGFB PDGFB WAS WAS GPCPD1 GPCPD1 KRAS KRAS SP1 SP1 WASF1 WASF1 LYPLA1 LYPLA1 JUN JUN RPS6KB1 RPS6KB1 MAP2K1 MAP2K1 SOS1 SOS1 PDGFA PDGFA PLPP2 PLPP2 PCYT1A PCYT1A PIK3CD PIK3CD GRB2 GRB2 DGKE DGKE SOS2 SOS2 MAPK1 MAPK1 PLA2G4D PLA2G4D PLA2G4A PLA2G4A PIK3CB PIK3CB DGKB DGKB RAF1 RAF1 SLC44A1 SLC44A1 TSC2 TSC2 NRAS NRAS DGKG DGKG MAPK3 MAPK3 CHKA CHKA SLC44A2 SLC44A2 PLD1 PLD1 PIK3CA PIK3CA MAPK8 MAPK8 DGKA DGKA EGFR EGFR PIP5K1B PIP5K1B TSC1 TSC1 RALGDS RALGDS PIK3R2 PIK3R2 DGKI DGKI FOS FOS PIK3R3 PIK3R3 MAPK9 MAPK9 SLC22A1 SLC22A1 DGKH DGKH SLC44A3 SLC44A3 DGKZ DGKZ PDGFD PDGFD SLC22A5 SLC22A5 PLA2G4E PLA2G4E RPS6KB2 RPS6KB2 PLCG1 PLCG1 DGKD DGKD RAC2 RAC2 PDGFC PDGFC SLC22A3 SLC22A3 AKT2 AKT2 EGF EGF PLPP3 PLPP3 CHPT1 CHPT1 SLC44A5 SLC44A5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (579 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (558 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
SLC22A2Solute carrier family 22 member 2. (553 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (825 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1131 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (550 aa)
LOC101083342Phospholipase A2. (781 aa)
WASF2WASP family member 2. (498 aa)
PLD2Phospholipase. (984 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
WASF3WASP family member 3. (502 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (784 aa)
DGKQDiacylglycerol kinase. (942 aa)
RHEBRas homolog, mTORC1 binding. (187 aa)
MAP2K2Protein kinase domain-containing protein. (549 aa)
DGKKDiacylglycerol kinase. (1254 aa)
PDGFBPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (245 aa)
WASWASP actin nucleation promoting factor. (501 aa)
GPCPD1Glycerophosphocholine phosphodiesterase 1. (672 aa)
KRASUncharacterized protein. (380 aa)
SP1Sp1 transcription factor. (786 aa)
WASF1WASP family member 1. (570 aa)
LYPLA1Lysophospholipase 1. (230 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
PLPP2Phospholipid phosphatase 2. (294 aa)
PCYT1APhosphate cytidylyltransferase 1, choline, alpha. (367 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
DGKEDiacylglycerol kinase. (564 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
PLA2G4DPhospholipase A2. (814 aa)
PLA2G4APhospholipase A2. (749 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
DGKBDiacylglycerol kinase. (820 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
SLC44A1Solute carrier family 44 member 1; Belongs to the CTL (choline transporter-like) family. (719 aa)
TSC2TSC complex subunit 2. (1806 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
DGKGDiacylglycerol kinase. (790 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CHKACholine kinase alpha. (497 aa)
SLC44A2Solute carrier family 44 member 2; Belongs to the CTL (choline transporter-like) family. (810 aa)
PLD1Phospholipase. (1074 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
DGKADiacylglycerol kinase. (734 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (548 aa)
TSC1TSC complex subunit 1. (1110 aa)
RALGDSUncharacterized protein. (885 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
DGKIDiacylglycerol kinase. (1082 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
PIK3R3Uncharacterized protein. (461 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
SLC22A1Solute carrier family 22 member 1. (554 aa)
DGKHDiacylglycerol kinase. (1220 aa)
SLC44A3Solute carrier family 44 member 3; Belongs to the CTL (choline transporter-like) family. (727 aa)
DGKZDiacylglycerol kinase. (1119 aa)
PDGFDPlatelet derived growth factor D. (380 aa)
SLC22A5Solute carrier family 22 member 5. (557 aa)
PLA2G4EPhospholipase A2. (862 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
PLCG1Phosphoinositide phospholipase C. (1391 aa)
DGKDDiacylglycerol kinase. (1222 aa)
RAC2Rac family small GTPase 2. (234 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
SLC22A3Solute carrier family 22 member 3. (647 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa)
PLPP3acidPPc domain-containing protein. (324 aa)
CHPT1Choline phosphotransferase 1. (496 aa)
SLC44A5Solute carrier family 44 member 5; Belongs to the CTL (choline transporter-like) family. (723 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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