STRINGSTRING
MTOR MTOR JAK1 JAK1 TICAM2 TICAM2 STAT3 STAT3 HRAS HRAS NFKBIB NFKBIB HIF1A HIF1A AKT3 AKT3 CD4 CD4 PTPN6 PTPN6 AKT1 AKT1 BATF2 BATF2 NFKBIA NFKBIA NFKB1 NFKB1 CSNK2B CSNK2B IFNG IFNG CD274 CD274 ZAP70 ZAP70 PIK3R1 PIK3R1 CD3D CD3D MAPK11 MAPK11 MAP2K2 MAP2K2 CD28 CD28 EML4 EML4 MAP2K6 MAP2K6 KRAS KRAS PTEN PTEN CSNK2A2 CSNK2A2 TLR2 TLR2 IKBKG IKBKG JUN JUN RPS6KB1 RPS6KB1 MAP2K1 MAP2K1 NFATC3 NFATC3 IFNGR1 IFNGR1 PIK3CD PIK3CD TLR4 TLR4 MAPK14 MAPK14 PPP3CB PPP3CB MAPK1 MAPK1 PIK3CB PIK3CB MAP3K3 MAP3K3 PTPN11 PTPN11 MAPK12 MAPK12 RAF1 RAF1 NRAS NRAS MAPK3 MAPK3 CNRIP1 CNRIP1 MYD88 MYD88 PPP3CA PPP3CA BATF BATF PIK3CA PIK3CA TLR9 TLR9 LCK LCK IFNGR2 IFNGR2 PRKCQ PRKCQ EGFR EGFR PPP3CC PPP3CC TICAM1 TICAM1 PIK3R2 PIK3R2 ALK ALK IKBKB IKBKB NFATC2 NFATC2 PDCD1 PDCD1 FOS FOS PIK3R3 PIK3R3 CSNK2A1 CSNK2A1 BATF3 BATF3 TRAF6 TRAF6 RELA RELA NFKBIE NFKBIE JAK2 JAK2 STAT1 STAT1 NFATC1 NFATC1 RPS6KB2 RPS6KB2 PLCG1 PLCG1 RASGRP1 RASGRP1 LOC111559549 LOC111559549 AKT2 AKT2 EGF EGF MAP2K3 MAP2K3 CHUK CHUK CD247 CD247
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2590 aa)
JAK1Tyrosine-protein kinase. (1157 aa)
TICAM2Toll like receptor adaptor molecule 2. (234 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
NFKBIBNFKB inhibitor beta. (354 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (825 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CD4CD4 molecule. (487 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (615 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
BATF2Basic leucine zipper ATF-like transcription factor 2. (295 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
NFKB1Nuclear factor kappa B subunit 1. (989 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (235 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
CD274CD274 molecule. (297 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
CD3DCD3d molecule. (170 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAP2K2Protein kinase domain-containing protein. (549 aa)
CD28T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa)
EML4EMAP like 4. (1006 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
KRASUncharacterized protein. (380 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (423 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
IFNGR1Interferon gamma receptor 1. (469 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the PP2C family. (698 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAP3K3Uncharacterized protein. (626 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
CNRIP1Uncharacterized protein. (324 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (308 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
LCKTyrosine-protein kinase. (520 aa)
IFNGR2Interferon gamma receptor 2. (390 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
PPP3CCSerine/threonine-protein phosphatase. (523 aa)
TICAM1Toll like receptor adaptor molecule 1. (815 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit 2. (726 aa)
ALKTyrosine-protein kinase receptor. (1279 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (760 aa)
NFATC2Nuclear factor of activated T cells 2. (916 aa)
PDCD1Programmed cell death 1. (278 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation (By similarity). In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and [...] (381 aa)
PIK3R3Uncharacterized protein. (461 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
BATF3Basic leucine zipper ATF-like transcription factor 3. (122 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
NFKBIENFKB inhibitor epsilon. (362 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
STAT1Signal transducer and activator of transcription. (885 aa)
NFATC1Nuclear factor of activated T cells 1. (1085 aa)
RPS6KB2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
PLCG1Phosphoinositide phospholipase C. (1391 aa)
RASGRP1RAS guanyl releasing protein 1. (877 aa)
LOC111559549Ig-like domain-containing protein. (247 aa)
AKT2Non-specific serine/threonine protein kinase. (571 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1213 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (383 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (774 aa)
CD247CD247 molecule. (250 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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