STRINGSTRING
IL23R IL23R IL12RB2 IL12RB2 STAT3 STAT3 TGFB1 TGFB1 IL1B IL1B IL21 IL21 NFKB1 NFKB1 IL1A IL1A NOD2 NOD2 IL17F IL17F IFNG IFNG LOC101090518 LOC101090518 IL21R IL21R TBX21 TBX21 IL12A IL12A IL23A IL23A IL10 IL10 IL2 IL2 TGFB3 TGFB3 STAT6 STAT6 IL22 IL22 STAT4 STAT4 IL18RAP IL18RAP TLR2 TLR2 JUN JUN IFNGR1 IFNGR1 TLR4 TLR4 IL12B IL12B IL18 IL18 TLR5 TLR5 IL17A IL17A SLC26A3-2 SLC26A3-2 IL13 IL13 IL18R1 IL18R1 LOC101082653 LOC101082653 IFNGR2 IFNGR2 RORA RORA IL4R IL4R LOC101084962 LOC101084962 LOC101090265 LOC101090265 GATA3 GATA3 LOC111558970 LOC111558970 LOC101082906 LOC101082906 LOC101090771 LOC101090771 RELA RELA MAF MAF IL2RG IL2RG STAT1 STAT1 TNF TNF LOC111560444 LOC111560444 LOC101084108 LOC101084108 NFATC1 NFATC1 RORC RORC SMAD2 SMAD2 IL5 IL5 LOC111556169 LOC111556169 LOC111559549 LOC111559549 LOC111560443 LOC111560443 IL12RB1 IL12RB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL23RInterleukin 23 receptor. (631 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (861 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (302 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (161 aa)
NFKB1Nuclear factor kappa B subunit 1. (989 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
IL17FInterleukin 17F. (157 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
LOC101090518Ig-like domain-containing protein; Belongs to the MHC class II family. (250 aa)
IL21RInterleukin 21 receptor. (538 aa)
TBX21T-box transcription factor 21. (535 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
IL23AInterleukin 23 subunit alpha. (196 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
STAT6Signal transducer and activator of transcription. (844 aa)
IL22Interleukin 22. (179 aa)
STAT4Signal transducer and activator of transcription. (758 aa)
IL18RAPInterleukin 18 receptor accessory protein. (586 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
IFNGR1Interferon gamma receptor 1. (469 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (870 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (359 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (890 aa)
IL17AInterleukin 17A. (155 aa)
SLC26A3-2Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa)
IL13Interleukin 13. (144 aa)
IL18R1Interleukin 18 receptor 1. (539 aa)
LOC101082653Ig-like domain-containing protein. (276 aa)
IFNGR2Interferon gamma receptor 2. (390 aa)
RORARAR related orphan receptor A. (523 aa)
IL4RInterleukin 4 receptor. (818 aa)
LOC101084962Ig-like domain-containing protein. (253 aa)
LOC101090265Ig-like domain-containing protein. (263 aa)
GATA3GATA binding protein 3. (444 aa)
LOC111558970Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa)
LOC101082906Ig-like domain-containing protein. (282 aa)
LOC101090771Ig-like domain-containing protein; Belongs to the MHC class II family. (257 aa)
RELARELA proto-oncogene, NF-kB subunit. (555 aa)
MAFMAF bZIP transcription factor; Belongs to the bZIP family. (418 aa)
IL2RGFibronectin type-III domain-containing protein. (390 aa)
STAT1Signal transducer and activator of transcription. (885 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
LOC111560444Ig-like domain-containing protein; Belongs to the MHC class II family. (250 aa)
LOC101084108Ig-like domain-containing protein; Belongs to the MHC class II family. (344 aa)
NFATC1Nuclear factor of activated T cells 1. (1085 aa)
RORCRAR related orphan receptor C. (518 aa)
SMAD2Mothers against decapentaplegic homolog. (721 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
LOC111556169Ig-like domain-containing protein. (276 aa)
LOC111559549Ig-like domain-containing protein. (247 aa)
LOC111560443Ig-like domain-containing protein; Belongs to the MHC class II family. (322 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (673 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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