STRINGSTRING
C1R C1R C8G C8G C1QB C1QB C5 C5 FCGR3A FCGR3A IFNG IFNG CD80 CD80 LOC101090518 LOC101090518 H2BC18 H2BC18 SSB SSB C9 C9 IL10 IL10 MACROH2A1 MACROH2A1 CD40 CD40 CD28 CD28 GRIN2A GRIN2A H2BC1 H2BC1 C6 C6 C1QA C1QA LOC101083005 LOC101083005 M3WZ36_FELCA M3WZ36_FELCA LOC101096314 LOC101096314 H3F3A H3F3A H2BU1 H2BU1 H2AJ H2AJ LOC101087936 LOC101087936 LOC101088423 LOC101088423 LOC101092488 LOC101092488 LOC101097798 LOC101097798 H2AW H2AW H2AC6 H2AC6 C7 C7 H2AC1 H2AC1 M3XGB0_FELCA M3XGB0_FELCA LOC101087401 LOC101087401 ACTN4 ACTN4 C8B C8B ENSFCAP00000028809 ENSFCAP00000028809 SNRPD1 SNRPD1 CD40LG CD40LG RO60 RO60 SLC26A3-2 SLC26A3-2 LOC101093519 LOC101093519 SNRPB SNRPB LOC101082653 LOC101082653 TRIM21 TRIM21 LOC101082235 LOC101082235 LOC101084962 LOC101084962 HIST2H3C HIST2H3C LOC105260541 LOC105260541 LOC101090265 LOC101090265 ENSFCAP00000042498 ENSFCAP00000042498 ENSFCAP00000043372 ENSFCAP00000043372 MACROH2A2 MACROH2A2 LOC111558970 LOC111558970 GRIN2B GRIN2B LOC101082906 LOC101082906 LOC101088237 LOC101088237 LOC101090771 LOC101090771 SNRPD3 SNRPD3 LOC101083265 LOC101083265 LOC101086971 LOC101086971 CTSG CTSG C1QC C1QC H2BC3 H2BC3 TNF TNF LOC101085206 LOC101085206 LOC111560444 LOC111560444 LOC101084108 LOC101084108 LOC101094346 LOC101094346 ACTN1 ACTN1 C1S C1S H2BC5 H2BC5 ENSFCAP00000054113 ENSFCAP00000054113 H2AX H2AX C8A C8A LOC111558783 LOC111558783 ELANE ELANE C2 C2 LOC111556169 LOC111556169 LOC111559549 LOC111559549 CD86 CD86 LOC111560443 LOC111560443 H2BE1 H2BE1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C1RPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (293 aa)
C8GComplement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family. (202 aa)
C1QBComplement C1q B chain. (254 aa)
C5Complement C5. (1680 aa)
FCGR3ACD16. (250 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (167 aa)
CD80B-lymphocyte activation antigen B7-1 (CD80). (292 aa)
LOC101090518Ig-like domain-containing protein; Belongs to the MHC class II family. (250 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (132 aa)
SSBSmall RNA binding exonuclease protection factor La. (406 aa)
C9Complement C9. (562 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
CD40CD40 molecule. (324 aa)
CD28T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1464 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
C6Complement C6. (933 aa)
C1QAComplement C1q A chain. (245 aa)
LOC101083005Histone H2A; Belongs to the histone H2A family. (130 aa)
M3WZ36_FELCAHistone H2A; Belongs to the histone H2A family. (140 aa)
LOC101096314Histone H2B; Belongs to the histone H2B family. (126 aa)
H3F3AHistone H3; Belongs to the histone H3 family. (136 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (129 aa)
LOC101087936Uncharacterized protein. (373 aa)
LOC101088423Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC101092488Histone domain-containing protein; Belongs to the histone H2B family. (127 aa)
LOC101097798Histone H2A; Belongs to the histone H2A family. (113 aa)
H2AWHistone H2A; Belongs to the histone H2A family. (130 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
C7Complement C7. (843 aa)
H2AC1Histone H2A; Belongs to the histone H2A family. (131 aa)
M3XGB0_FELCAHistone H2A; Belongs to the histone H2A family. (155 aa)
LOC101087401Histone H2A; Belongs to the histone H2A family. (128 aa)
ACTN4Actinin alpha 4. (933 aa)
C8BComplement C8 beta chain. (637 aa)
ENSFCAP00000028809Histone H2B; Belongs to the histone H2B family. (67 aa)
SNRPD1Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. (119 aa)
CD40LGCD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (260 aa)
RO60Ro60, Y RNA binding protein. (538 aa)
SLC26A3-2Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa)
LOC101093519Histone H2A; Belongs to the histone H2A family. (130 aa)
SNRPBSmall nuclear ribonucleoprotein-associated protein. (231 aa)
LOC101082653Ig-like domain-containing protein. (276 aa)
TRIM21Tripartite motif containing 21. (469 aa)
LOC101082235Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC101084962Ig-like domain-containing protein. (253 aa)
HIST2H3CHistone cluster 2 H3 family member c. (258 aa)
LOC105260541Histone H3; Belongs to the histone H3 family. (136 aa)
LOC101090265Ig-like domain-containing protein. (263 aa)
ENSFCAP00000042498Histone domain-containing protein; Belongs to the histone H2B family. (118 aa)
ENSFCAP00000043372Histone H3; Belongs to the histone H3 family. (136 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
LOC111558970Ig-like domain-containing protein; Belongs to the MHC class II family. (254 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1486 aa)
LOC101082906Ig-like domain-containing protein. (282 aa)
LOC101088237Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC101090771Ig-like domain-containing protein; Belongs to the MHC class II family. (257 aa)
SNRPD3Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. (126 aa)
LOC101083265Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC101086971Histone H2B; Belongs to the histone H2B family. (126 aa)
CTSGCathepsin G; Belongs to the peptidase S1 family. (292 aa)
C1QCComplement C1q C chain. (245 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
LOC101085206Histone H2A; Belongs to the histone H2A family. (132 aa)
LOC111560444Ig-like domain-containing protein; Belongs to the MHC class II family. (250 aa)
LOC101084108Ig-like domain-containing protein; Belongs to the MHC class II family. (344 aa)
LOC101094346Uncharacterized protein. (1908 aa)
ACTN1Actinin alpha 1. (927 aa)
C1SComplement C1s; Belongs to the peptidase S1 family. (710 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSFCAP00000054113Uncharacterized protein. (84 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
C8AComplement C8 alpha chain. (640 aa)
LOC111558783Histone H2A; Belongs to the histone H2A family. (111 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (339 aa)
C2Complement C2; Belongs to the peptidase S1 family. (870 aa)
LOC111556169Ig-like domain-containing protein. (276 aa)
LOC111559549Ig-like domain-containing protein. (247 aa)
CD86B-lymphocyte activation antigen B7-2 (CD86). (332 aa)
LOC111560443Ig-like domain-containing protein; Belongs to the MHC class II family. (322 aa)
H2BE1Histone H2B; Belongs to the histone H2B family. (122 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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