STRINGSTRING
PRKAB1 PRKAB1 CACNG7 CACNG7 ITGA8 ITGA8 MYBPC3 MYBPC3 ITGA2B ITGA2B CACNA1F CACNA1F ITGA3 ITGA3 SGCA SGCA CACNA1S CACNA1S ITGA10 ITGA10 TGFB1 TGFB1 ITGB7 ITGB7 ITGA11 ITGA11 ACTG1 ACTG1 ITGB8 ITGB8 LAMA1 LAMA1 TPM4 TPM4 MYH6 MYH6 ITGA5 ITGA5 ITGA4 ITGA4 CACNG3 CACNG3 EMD EMD LMNA LMNA ITGA2 ITGA2 TPM2 TPM2 ITGA7 ITGA7 ACTC1 ACTC1 TGFB3 TGFB3 EDN1 EDN1 TNNC1 TNNC1 CACNG2 CACNG2 CACNG8 CACNG8 ITGB6 ITGB6 CACNG5 CACNG5 AGT AGT SLC8A2 SLC8A2 ATP2A2 ATP2A2 PRKAA1 PRKAA1 CACNA1C CACNA1C PRKAG3 PRKAG3 CACNG4 CACNG4 CACNA2D4 CACNA2D4 ITGA1 ITGA1 ITGB1 ITGB1 PRKAG1 PRKAG1 CACNB4 CACNB4 ITGB3 ITGB3 ITGB5 ITGB5 PRKAA2 PRKAA2 SGCD SGCD CACNA2D1 CACNA2D1 ACE ACE PRKAB2 PRKAB2 ITGA6 ITGA6 SLC8A3 SLC8A3 CACNG1 CACNG1 SLC8A1 SLC8A1 TPM3 TPM3 CACNB2 CACNB2 IGF1 IGF1 ATP2A1 ATP2A1 SGCG SGCG DES DES MYL3 MYL3 CACNG6 CACNG6 DAG1 DAG1 ATP2A3 ATP2A3 TNF TNF ITGAV ITGAV CACNA1D CACNA1D TTN TTN SGCB SGCB LAMA2 LAMA2 RYR2 RYR2 DMD DMD MYL2 MYL2 CACNA2D3 CACNA2D3 CACNA2D2 CACNA2D2 ITGA9 ITGA9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
MYBPC3Myosin binding protein C, cardiac. (1273 aa)
ITGA2BIntegrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1086 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1984 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
SGCASarcoglycan alpha. (439 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1871 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1165 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (797 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1189 aa)
ACTG1Actin gamma 1. (375 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
LAMA1Laminin subunit alpha 1. (3080 aa)
TPM4Tropomyosin 4; Belongs to the tropomyosin family. (284 aa)
MYH6Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1104 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1036 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (315 aa)
EMDEmerin. (260 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (664 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1177 aa)
TPM2Tropomyosin 2; Belongs to the tropomyosin family. (284 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
ACTC1Actin alpha cardiac muscle 1. (616 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (201 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (422 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (788 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (324 aa)
AGTAngiotensinogen; Belongs to the serpin family. (547 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (921 aa)
ATP2A2Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] (1006 aa)
PRKAA1Non-specific serine/threonine protein kinase. (573 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2187 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (607 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
CACNA2D4Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1123 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (801 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (519 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (800 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
SGCDSarcoglycan delta. (289 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1103 aa)
ACEAngiotensin-converting enzyme. (1307 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
SLC8A1Sodium/calcium exchanger 1; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation- contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels r [...] (973 aa)
TPM3Tropomyosin 3; Belongs to the tropomyosin family. (334 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (632 aa)
IGF1Insulin like growth factor 1. (195 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1049 aa)
SGCGSarcoglycan gamma. (354 aa)
DESDesmin; Belongs to the intermediate filament family. (514 aa)
MYL3Myosin light chain 3. (196 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (262 aa)
DAG1Peptidase S72 domain-containing protein. (892 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (999 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (321 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2216 aa)
TTNTitin. (27108 aa)
SGCBSarcoglycan beta. (342 aa)
LAMA2Laminin subunit alpha 2. (3125 aa)
RYR2Ryanodine receptor 2. (4967 aa)
DMDDystrophin. (3677 aa)
MYL2Myosin light chain 2. (174 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (1091 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1156 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1083 aa)
Your Current Organism:
Felis catus
NCBI taxonomy Id: 9685
Other names: F. catus, Felis domesticus, Felis silvestris catus, Korat cats, cat, cats, domestic cat
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