(42 nodes) Negative regulation of I-kappaB kinase/NF-kappaB signaling network (Panthera pardus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RIOK3	Serine/threonine-protein kinase RIO3. (519 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (623 aa)
	NLRC3	NLR family CARD domain-containing protein 3. (1073 aa)
	PPM1M	Protein phosphatase 1M isoform X1. (461 aa)
	ABL1	Abelson tyrosine-protein kinase 1. (1150 aa)
	ZMYND11	Zinc finger MYND domain-containing protein 11 isoform X1. (602 aa)
	PYCARD	Apoptosis-associated speck-like protein containing a CARD. (195 aa)
	TRIM59	Tripartite motif-containing protein 59. (325 aa)
	TANK	TRAF family member-associated NF-kappa-B activator isoform X1. (426 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2 isoform X1. (230 aa)
	ADIPOQ	Adiponectin isoform X1. (244 aa)
	NR1H4	Bile acid receptor isoform X1. (486 aa)
	TNIP1	TNFAIP3-interacting protein 1 isoform X1. (635 aa)
	PPM1N	Probable protein phosphatase 1N isoform X1. (416 aa)
	NLRX1	NLR family member X1. (975 aa)
	OTUD7B	OTU domain-containing protein 7B. (843 aa)
	PPM1B	Protein phosphatase 1B isoform X1. (479 aa)
	DAB2IP	Disabled homolog 2-interacting protein isoform X1. (1173 aa)
	CCDC22	Coiled-coil domain-containing protein 22. (627 aa)
	CACTIN	Cactin, spliceosome C complex subunit. (649 aa)
	USP10	Ubiquitin carboxyl-terminal hydrolase 10 isoform X1. (798 aa)
	OTUD7A	OTU domain-containing protein 7A. (925 aa)
	TRIM39	E3 ubiquitin-protein ligase TRIM39 isoform X1. (488 aa)
	ENSPPRP00000015560	Tripartite motif-containing protein 60-like. (221 aa)
	TNFAIP3	Tumor necrosis factor, alpha-induced protein 3. (790 aa)
	PPM1A	Protein phosphatase 1A isoform X1. (486 aa)
	ESR1	Estrogen receptor isoform X1. (595 aa)
	NLRP12	NACHT, LRR and PYD domains-containing protein 12 isoform X1. (1061 aa)
	MAPKBP1	Mitogen-activated protein kinase-binding protein 1 isoform X1. (1510 aa)
	NLRP6	NACHT, LRR and PYD domains-containing protein 6 isoform X1. (934 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform X1. (745 aa)
	STAT1	Signal transducer and activator of transcription 1-alpha/beta. (750 aa)
	ZC3H12A	Endoribonuclease ZC3H12A. (597 aa)
	ASH1L	Histone-lysine N-methyltransferase ASH1L isoform X1. (2961 aa)
	CASP10	Caspase 10. (521 aa)
	CASP8	Caspase-8 isoform X1. (464 aa)
	TRIM75P	Putative tripartite motif-containing protein 75. (469 aa)
	RHOH	Rho-related GTP-binding protein RhoH. (191 aa)
	RORA	Nuclear receptor ROR-alpha isoform X1. (542 aa)
	TLE1	Transducin-like enhancer protein 1 isoform X1. (770 aa)
	RIPK1	Receptor-interacting serine/threonine-protein kinase 1. (671 aa)
	TNIP3	TNFAIP3-interacting protein 3 isoform X1. (372 aa)

Your Current Organism:

Panthera pardus

NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	SIRT1	ENSPPRP00000010179	ENSPPRP00000022514	Adiponectin isoform X1.	NAD-dependent protein deacetylase sirtuin-1 isoform X1.	0.507
CACTIN	ENSPPRP00000015560	ENSPPRP00000013950	ENSPPRP00000015560	Cactin, spliceosome C complex subunit.	Tripartite motif-containing protein 60-like.	0.468
CACTIN	TRIM39	ENSPPRP00000013950	ENSPPRP00000015069	Cactin, spliceosome C complex subunit.	E3 ubiquitin-protein ligase TRIM39 isoform X1.	0.468
CACTIN	TRIM75P	ENSPPRP00000013950	ENSPPRP00000027968	Cactin, spliceosome C complex subunit.	Putative tripartite motif-containing protein 75.	0.468
CASP10	CASP8	ENSPPRP00000024649	ENSPPRP00000024885	Caspase 10.	Caspase-8 isoform X1.	0.765
CASP10	PYCARD	ENSPPRP00000024649	ENSPPRP00000008312	Caspase 10.	Apoptosis-associated speck-like protein containing a CARD.	0.638
CASP10	RIPK1	ENSPPRP00000024649	ENSPPRP00000001555	Caspase 10.	Receptor-interacting serine/threonine-protein kinase 1.	0.904
CASP8	CASP10	ENSPPRP00000024885	ENSPPRP00000024649	Caspase-8 isoform X1.	Caspase 10.	0.765
CASP8	ESR1	ENSPPRP00000024885	ENSPPRP00000017932	Caspase-8 isoform X1.	Estrogen receptor isoform X1.	0.522
CASP8	PYCARD	ENSPPRP00000024885	ENSPPRP00000008312	Caspase-8 isoform X1.	Apoptosis-associated speck-like protein containing a CARD.	0.975
CASP8	RIPK1	ENSPPRP00000024885	ENSPPRP00000001555	Caspase-8 isoform X1.	Receptor-interacting serine/threonine-protein kinase 1.	0.998
CASP8	STAT1	ENSPPRP00000024885	ENSPPRP00000023300	Caspase-8 isoform X1.	Signal transducer and activator of transcription 1-alpha/beta.	0.443
ENSPPRP00000015560	CACTIN	ENSPPRP00000015560	ENSPPRP00000013950	Tripartite motif-containing protein 60-like.	Cactin, spliceosome C complex subunit.	0.468
ESR1	CASP8	ENSPPRP00000017932	ENSPPRP00000024885	Estrogen receptor isoform X1.	Caspase-8 isoform X1.	0.522
ESR1	SIRT1	ENSPPRP00000017932	ENSPPRP00000022514	Estrogen receptor isoform X1.	NAD-dependent protein deacetylase sirtuin-1 isoform X1.	0.461
ESR1	STAT1	ENSPPRP00000017932	ENSPPRP00000023300	Estrogen receptor isoform X1.	Signal transducer and activator of transcription 1-alpha/beta.	0.611
MAPKBP1	PPM1A	ENSPPRP00000021691	ENSPPRP00000017503	Mitogen-activated protein kinase-binding protein 1 isoform X1.	Protein phosphatase 1A isoform X1.	0.508
NLRC3	NLRX1	ENSPPRP00000005965	ENSPPRP00000011182	NLR family CARD domain-containing protein 3.	NLR family member X1.	0.432
NLRP12	NLRP6	ENSPPRP00000019622	ENSPPRP00000022041	NACHT, LRR and PYD domains-containing protein 12 isoform X1.	NACHT, LRR and PYD domains-containing protein 6 isoform X1.	0.461
NLRP12	PYCARD	ENSPPRP00000019622	ENSPPRP00000008312	NACHT, LRR and PYD domains-containing protein 12 isoform X1.	Apoptosis-associated speck-like protein containing a CARD.	0.960