(88 nodes) Extrinsic apoptotic signaling pathway network (Panthera pardus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BAG3	BAG family molecular chaperone regulator 3. (579 aa)
	CASP2	Caspase-2 isoform X1. (451 aa)
	G0S2	G0/G1 switch protein 2. (102 aa)
	FASLG	Tumor necrosis factor ligand superfamily member 6. (278 aa)
	CD27	Tumor necrosis factor receptor superfamily member 7. (260 aa)
	RAF1	RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
	YAP1	Transcriptional coactivator YAP1. (324 aa)
	DDX47	Probable ATP-dependent RNA helicase DDX47. (455 aa)
	FGFR3	Fibroblast growth factor receptor 3 isoform X1. (791 aa)
	MLLT11	Protein AF1q. (90 aa)
	EYA2	Eyes absent homolog 2 isoform X1. (538 aa)
	WWOX	WW domain-containing oxidoreductase isoform X1. (414 aa)
	FOXO3	Forkhead box protein O3. (672 aa)
	CASP8	Caspase-8 isoform X1. (464 aa)
	CASP10	Caspase 10. (521 aa)
	ITPRIPL2	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2. (532 aa)
	DAPK1	Death-associated protein kinase 1 isoform X1. (1430 aa)
	TRADD	Tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1. (311 aa)
	FAS	Fas cell surface death receptor. (293 aa)
	PML	Probable transcription factor PML. (876 aa)
	DELE1	Death ligand signal enhancer isoform X1. (515 aa)
	RB1CC1	RB1-inducible coiled-coil protein 1 isoform X1. (1593 aa)
	PARP2	Poly [ADP-ribose] polymerase 2 isoform X1. (579 aa)
	BAK1	Bcl-2 homologous antagonist/killer. (211 aa)
	TGFB2	Transforming growth factor beta-2 isoform X1. (442 aa)
	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1. (350 aa)
	IL7	Interleukin-7 isoform X1. (158 aa)
	NF1	Neurofibromin 1. (2841 aa)
	PABPN1	Polyadenylate-binding protein 2. (306 aa)
	DEDD	Death effector domain-containing protein. (318 aa)
	P2RX7	P2X purinoceptor 7 isoform X1. (593 aa)
	BCL2L2	Apoptosis regulator BCL-W. (193 aa)
	KRT8	Keratin, type II cytoskeletal 8. (483 aa)
	KRT18	Keratin, type I cytoskeletal 18. (430 aa)
	IFNG	Interferon gamma. (167 aa)
	INHBA	Inhibin beta A chain isoform X1. (424 aa)
	ENSPPRP00000016976	annotation not available (392 aa)
	SIVA1	Apoptosis regulatory protein Siva isoform X1. (175 aa)
	IL4	Interleukin 4. (134 aa)
	IL2	Interleukin 2. (154 aa)
	BAD	Bcl2-associated agonist of cell death. (169 aa)
	SFRP1	Secreted frizzled-related protein 1 isoform X1. (314 aa)
	DEDD2	DNA-binding death effector domain-containing protein 2. (327 aa)
	STK3	Serine/threonine-protein kinase 3 isoform X1. (491 aa)
	DAB2IP	Disabled homolog 2-interacting protein isoform X1. (1173 aa)
	IL12A	Interleukin-12 subunit alpha isoform X1. (222 aa)
	IL1A	Interleukin-1 alpha isoform X1. (262 aa)
	BCL2L10	BCL2 like 10. (230 aa)
	BCL2L11	Bcl-2-like protein 11 isoform X1. (197 aa)
	DDX3X	ATP-dependent RNA helicase DDX3X isoform X1. (662 aa)
	GSK3B	Glycogen synthase kinase-3 beta isoform X1. (433 aa)
	GSK3A	Glycogen synthase kinase 3 alpha. (483 aa)
	TNF	Tumor necrosis factor superfamily, member 2. (233 aa)
	SKIL	Ski-like protein. (684 aa)
	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B. (463 aa)
	TGFB1	Transforming growth factor beta-1 isoform X1. (390 aa)
	EYA1	Eyes absent homolog 1 isoform X1. (591 aa)
	HIPK1	Homeodomain-interacting protein kinase 1 isoform X1. (1210 aa)
	SMAD3	Mothers against decapentaplegic homolog 3 isoform X1. (425 aa)
	BCL2A1	Hematopoietic Bcl-2-related protein A1. (174 aa)
	COL2A1	Collagen alpha-1(II) chain isoform X1. (1487 aa)
	ENSPPRP00000007447	annotation not available (205 aa)
	ERBB3	Receptor tyrosine-protein kinase erbB-3 isoform X1. (1330 aa)
	DAXX	Death domain-associated protein 6 isoform X1. (745 aa)
	FGF10	Fibroblast growth factor 10. (207 aa)
	RNF41	E3 ubiquitin-protein ligase NRDP1. (317 aa)
	TNFSF12	Tumor necrosis factor ligand superfamily member 12. (249 aa)
	PIDD1	Leucine-rich repeats and death domain-containing protein. (913 aa)
	TLR3	Toll-like receptor 3. (904 aa)
	BCL2	Apoptosis regulator Bcl-2. (236 aa)
	LOC109253092	Apoptosis regulator BAX. (173 aa)
	LOC109253093	Apoptosis regulator BAX isoform X1. (192 aa)
	ACVR1B	Activin A receptor type 1B. (546 aa)
	NDUFA13	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 13. (144 aa)
	BCL2L1	Bcl-2-like 1 (apoptosis regulator Bcl-X). (233 aa)
	PTPRC	Receptor-type tyrosine-protein phosphatase C isoform X1. (1271 aa)
	BOK	BCL2 family apoptosis regulator BOK. (213 aa)
	PDIA3	Protein disulfide-isomerase A3. (505 aa)
	YJEFN3	YjeF N-terminal domain containing 3. (232 aa)
	STK4	Serine/threonine-protein kinase 4. (484 aa)
	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
	SORT1	Sortilin isoform X1. (833 aa)
	CASP8AP2	CASP8-associated protein 2 isoform X1. (1959 aa)
	PDPK1	3-phosphoinositide-dependent protein kinase 1 isoform X1. (531 aa)
	RIPK1	Receptor-interacting serine/threonine-protein kinase 1. (671 aa)
	ITGAV	Integrin alpha V. (1047 aa)
	FADD	Fas associated via death domain. (199 aa)
	CTTN	Cortactin. (541 aa)

Your Current Organism:

Panthera pardus

NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR1B	INHBA	ENSPPRP00000003707	ENSPPRP00000017102	Activin A receptor type 1B.	Inhibin beta A chain isoform X1.	0.963
ACVR1B	SMAD3	ENSPPRP00000003707	ENSPPRP00000008496	Activin A receptor type 1B.	Mothers against decapentaplegic homolog 3 isoform X1.	0.844
ACVR1B	TGFB1	ENSPPRP00000003707	ENSPPRP00000009046	Activin A receptor type 1B.	Transforming growth factor beta-1 isoform X1.	0.744
ACVR1B	TGFB2	ENSPPRP00000003707	ENSPPRP00000022356	Activin A receptor type 1B.	Transforming growth factor beta-2 isoform X1.	0.448
BAD	BAK1	ENSPPRP00000015384	ENSPPRP00000022494	Bcl2-associated agonist of cell death.	Bcl-2 homologous antagonist/killer.	0.777
BAD	BCL2	ENSPPRP00000015384	ENSPPRP00000005353	Bcl2-associated agonist of cell death.	Apoptosis regulator Bcl-2.	0.998
BAD	BCL2A1	ENSPPRP00000015384	ENSPPRP00000007845	Bcl2-associated agonist of cell death.	Hematopoietic Bcl-2-related protein A1.	0.693
BAD	BCL2L1	ENSPPRP00000015384	ENSPPRP00000003126	Bcl2-associated agonist of cell death.	Bcl-2-like 1 (apoptosis regulator Bcl-X).	0.999
BAD	BCL2L10	ENSPPRP00000015384	ENSPPRP00000011774	Bcl2-associated agonist of cell death.	BCL2 like 10.	0.834
BAD	BCL2L11	ENSPPRP00000015384	ENSPPRP00000011605	Bcl2-associated agonist of cell death.	Bcl-2-like protein 11 isoform X1.	0.888
BAD	BCL2L2	ENSPPRP00000015384	ENSPPRP00000018233	Bcl2-associated agonist of cell death.	Apoptosis regulator BCL-W.	0.861
BAD	BOK	ENSPPRP00000015384	ENSPPRP00000002837	Bcl2-associated agonist of cell death.	BCL2 family apoptosis regulator BOK.	0.778
BAD	CASP2	ENSPPRP00000015384	ENSPPRP00000029765	Bcl2-associated agonist of cell death.	Caspase-2 isoform X1.	0.527
BAD	ENSPPRP00000007447	ENSPPRP00000015384	ENSPPRP00000007447	Bcl2-associated agonist of cell death.	annotation not available	0.777
BAD	FADD	ENSPPRP00000015384	ENSPPRP00000000370	Bcl2-associated agonist of cell death.	Fas associated via death domain.	0.493
BAD	LOC109253092	ENSPPRP00000015384	ENSPPRP00000005042	Bcl2-associated agonist of cell death.	Apoptosis regulator BAX.	0.788
BAD	LOC109253093	ENSPPRP00000015384	ENSPPRP00000004335	Bcl2-associated agonist of cell death.	Apoptosis regulator BAX isoform X1.	0.788
BAD	MCL1	ENSPPRP00000015384	ENSPPRP00000021074	Bcl2-associated agonist of cell death.	Induced myeloid leukemia cell differentiation protein Mcl-1.	0.747
BAD	RAF1	ENSPPRP00000015384	ENSPPRP00000028406	Bcl2-associated agonist of cell death.	RAF proto-oncogene serine/threonine-protein kinase isoform X1.	0.945
BAD	TRADD	ENSPPRP00000015384	ENSPPRP00000024222	Bcl2-associated agonist of cell death.	Tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1.	0.536