(31 nodes) Extrinsic apoptotic signaling pathway in absence of ligand network (Panthera pardus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	CASP2	Caspase-2 isoform X1. (451 aa)
	FADD	Fas associated via death domain. (199 aa)
	ITGAV	Integrin alpha V. (1047 aa)
	BOK	BCL2 family apoptosis regulator BOK. (213 aa)
	BCL2L1	Bcl-2-like 1 (apoptosis regulator Bcl-X). (233 aa)
	LOC109253093	Apoptosis regulator BAX isoform X1. (192 aa)
	LOC109253092	Apoptosis regulator BAX. (173 aa)
	BCL2	Apoptosis regulator Bcl-2. (236 aa)
	FGF10	Fibroblast growth factor 10. (207 aa)
	ERBB3	Receptor tyrosine-protein kinase erbB-3 isoform X1. (1330 aa)
	ENSPPRP00000007447	annotation not available (205 aa)
	COL2A1	Collagen alpha-1(II) chain isoform X1. (1487 aa)
	BAG3	BAG family molecular chaperone regulator 3. (579 aa)
	BCL2A1	Hematopoietic Bcl-2-related protein A1. (174 aa)
	EYA1	Eyes absent homolog 1 isoform X1. (591 aa)
	GSK3A	Glycogen synthase kinase 3 alpha. (483 aa)
	GSK3B	Glycogen synthase kinase-3 beta isoform X1. (433 aa)
	BCL2L11	Bcl-2-like protein 11 isoform X1. (197 aa)
	BCL2L10	BCL2 like 10. (230 aa)
	IL1A	Interleukin-1 alpha isoform X1. (262 aa)
	BAD	Bcl2-associated agonist of cell death. (169 aa)
	IL2	Interleukin 2. (154 aa)
	IL4	Interleukin 4. (134 aa)
	BCL2L2	Apoptosis regulator BCL-W. (193 aa)
	PABPN1	Polyadenylate-binding protein 2. (306 aa)
	NF1	Neurofibromin 1. (2841 aa)
	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1. (350 aa)
	BAK1	Bcl-2 homologous antagonist/killer. (211 aa)
	FAS	Fas cell surface death receptor. (293 aa)
	FOXO3	Forkhead box protein O3. (672 aa)
	EYA2	Eyes absent homolog 2 isoform X1. (538 aa)

Your Current Organism:

Panthera pardus

NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAD	BAK1	ENSPPRP00000015384	ENSPPRP00000022494	Bcl2-associated agonist of cell death.	Bcl-2 homologous antagonist/killer.	0.777
BAD	BCL2	ENSPPRP00000015384	ENSPPRP00000005353	Bcl2-associated agonist of cell death.	Apoptosis regulator Bcl-2.	0.998
BAD	BCL2A1	ENSPPRP00000015384	ENSPPRP00000007845	Bcl2-associated agonist of cell death.	Hematopoietic Bcl-2-related protein A1.	0.693
BAD	BCL2L1	ENSPPRP00000015384	ENSPPRP00000003126	Bcl2-associated agonist of cell death.	Bcl-2-like 1 (apoptosis regulator Bcl-X).	0.999
BAD	BCL2L10	ENSPPRP00000015384	ENSPPRP00000011774	Bcl2-associated agonist of cell death.	BCL2 like 10.	0.834
BAD	BCL2L11	ENSPPRP00000015384	ENSPPRP00000011605	Bcl2-associated agonist of cell death.	Bcl-2-like protein 11 isoform X1.	0.888
BAD	BCL2L2	ENSPPRP00000015384	ENSPPRP00000018233	Bcl2-associated agonist of cell death.	Apoptosis regulator BCL-W.	0.861
BAD	BOK	ENSPPRP00000015384	ENSPPRP00000002837	Bcl2-associated agonist of cell death.	BCL2 family apoptosis regulator BOK.	0.778
BAD	CASP2	ENSPPRP00000015384	ENSPPRP00000029765	Bcl2-associated agonist of cell death.	Caspase-2 isoform X1.	0.527
BAD	ENSPPRP00000007447	ENSPPRP00000015384	ENSPPRP00000007447	Bcl2-associated agonist of cell death.	annotation not available	0.777
BAD	FADD	ENSPPRP00000015384	ENSPPRP00000000370	Bcl2-associated agonist of cell death.	Fas associated via death domain.	0.493
BAD	LOC109253092	ENSPPRP00000015384	ENSPPRP00000005042	Bcl2-associated agonist of cell death.	Apoptosis regulator BAX.	0.788
BAD	LOC109253093	ENSPPRP00000015384	ENSPPRP00000004335	Bcl2-associated agonist of cell death.	Apoptosis regulator BAX isoform X1.	0.788
BAD	MCL1	ENSPPRP00000015384	ENSPPRP00000021074	Bcl2-associated agonist of cell death.	Induced myeloid leukemia cell differentiation protein Mcl-1.	0.747
BAG3	BCL2	ENSPPRP00000007732	ENSPPRP00000005353	BAG family molecular chaperone regulator 3.	Apoptosis regulator Bcl-2.	0.772
BAK1	BAD	ENSPPRP00000022494	ENSPPRP00000015384	Bcl-2 homologous antagonist/killer.	Bcl2-associated agonist of cell death.	0.777
BAK1	BCL2	ENSPPRP00000022494	ENSPPRP00000005353	Bcl-2 homologous antagonist/killer.	Apoptosis regulator Bcl-2.	0.970
BAK1	BCL2A1	ENSPPRP00000022494	ENSPPRP00000007845	Bcl-2 homologous antagonist/killer.	Hematopoietic Bcl-2-related protein A1.	0.785
BAK1	BCL2L1	ENSPPRP00000022494	ENSPPRP00000003126	Bcl-2 homologous antagonist/killer.	Bcl-2-like 1 (apoptosis regulator Bcl-X).	0.987
BAK1	BCL2L10	ENSPPRP00000022494	ENSPPRP00000011774	Bcl-2 homologous antagonist/killer.	BCL2 like 10.	0.467