STRINGSTRING
MAPK11 MAPK11 LOC109265767 LOC109265767 RHOA RHOA IL10RB IL10RB ATP6V0A4 ATP6V0A4 NOD2 NOD2 AKT2 AKT2 SYK SYK MYD88 MYD88 MAPK8 MAPK8 JAK2 JAK2 JAK1 JAK1 IL18 IL18 CALM2 CALM2 ATP6V0C ATP6V0C SPHK2 SPHK2 CLEC4E CLEC4E LOC109253093 LOC109253093 BCL10 BCL10 BCL2 BCL2 IL6 IL6 ITGB2 ITGB2 RAB5A RAB5A RFX5 RFX5 MRC1 MRC1 HLA-DPB1 HLA-DPB1 MAPK13 MAPK13 HLA-DPA1 HLA-DPA1 IL10RA IL10RA HLA-DOA HLA-DOA TLR9 TLR9 ITGAM ITGAM MAPK3 MAPK3 MAPK14 MAPK14 C3 C3 HLA-DRA HLA-DRA APAF1 APAF1 CORO1A CORO1A RAB7A RAB7A LOC109260707 LOC109260707 NOS2 NOS2 IL10 IL10 RELA RELA TGFB1 TGFB1 PPP3CC PPP3CC MAPK10 MAPK10 ARHGEF12 ARHGEF12 RFXANK RFXANK SRC SRC HLA-DMA HLA-DMA TCIRG1-2 TCIRG1-2 IFNGR1 IFNGR1 SPHK1 SPHK1 LOC109261022 LOC109261022 TNF TNF LOC109271415 LOC109271415 NFKB1 NFKB1 RAB5B RAB5B MALT1 MALT1 CARD9 CARD9 RAB5C RAB5C MRC2 MRC2 IL1A IL1A IL1B IL1B IL12A IL12A FCER1G FCER1G NFYA NFYA CREB1 CREB1 VDR VDR IRAK2 IRAK2 ATP6V0D2 ATP6V0D2 ATP6V0A2 ATP6V0A2 CAMK2D CAMK2D IRAK4 IRAK4 BAD BAD LAMP1 LAMP1 HSPD1 HSPD1 TGFB3 TGFB3 AKT1 AKT1 CTSS CTSS AKT3 AKT3 FCGR3A FCGR3A IFNG IFNG PIK3C3 PIK3C3 MAPK1 MAPK1 ATP6V0D1 ATP6V0D1 EP300 EP300 PLA2R1 PLA2R1 FCGR2B FCGR2B HLA-DOB HLA-DOB NFYB NFYB CAMK2A CAMK2A TLR4 TLR4 HSPA9 HSPA9 CYP27B1 CYP27B1 LOC109261307 LOC109261307 LOC109261394 LOC109261394 ATP6V0B ATP6V0B CD14 CD14 TGFB2 TGFB2 LOC109257074 LOC109257074 ATP6V1H ATP6V1H CALML6 CALML6 STAT1 STAT1 CLEC7A CLEC7A LSP1 LSP1 ATP6V0A1 ATP6V0A1 PPP3CA PPP3CA TRAF6 TRAF6 TRADD TRADD CTSD CTSD CREBBP CREBBP CASP3 CASP3 IL12B IL12B CASP8 CASP8 PPP3R1 PPP3R1 LOC109261297 LOC109261297 LOC109272282 LOC109272282 PLK3 PLK3 RIPK2 RIPK2 LOC109262226 LOC109262226 TLR2 TLR2 LOC109257442 LOC109257442 IL23A IL23A MAPK9 MAPK9 RAF1 RAF1 ATP6AP1 ATP6AP1 LBP LBP CALML5 CALML5 CALML3 CALML3 IFNB1 IFNB1 LOC109247112 LOC109247112 CEBPG CEBPG CD74 CD74 IFNGR2 IFNGR2 RFXAP RFXAP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK11LOW QUALITY PROTEIN: mitogen-activated protein kinase 11. (256 aa)
LOC109265767Mitogen-activated protein kinase 12 isoform X1. (367 aa)
RHOARas homolog gene family, member A. (192 aa)
IL10RBInterleukin-10 receptor subunit beta. (324 aa)
ATP6V0A4V-type H+-transporting ATPase subunit a. (840 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1040 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
SYKTyrosine-protein kinase SYK isoform X1. (636 aa)
MYD88Myeloid differentiation primary response protein MyD88 isoform X1. (308 aa)
MAPK8Mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase). (427 aa)
JAK2Tyrosine-protein kinase JAK2 isoform X1. (1131 aa)
JAK1Tyrosine-protein kinase JAK1. (1157 aa)
IL18Interleukin-18 isoform X1. (188 aa)
CALM2Calmodulin. (149 aa)
ATP6V0CV-type proton ATPase 16 kDa proteolipid subunit isoform X1. (155 aa)
SPHK2Sphingosine kinase 2. (658 aa)
CLEC4EC-type lectin domain family 4 member E isoform X1. (219 aa)
LOC109253093Apoptosis regulator BAX isoform X1. (192 aa)
BCL10B-cell lymphoma/leukemia 10. (233 aa)
BCL2Apoptosis regulator Bcl-2. (236 aa)
IL6Interleukin-6 isoform X1. (208 aa)
ITGB2Integrin beta 2. (750 aa)
RAB5ARas-related protein Rab-5A isoform X1. (215 aa)
RFX5DNA-binding protein RFX5 isoform X1. (601 aa)
MRC1Macrophage mannose receptor 1. (1455 aa)
HLA-DPB1LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain. (234 aa)
MAPK13Mitogen-activated protein kinase 13 isoform X1. (366 aa)
HLA-DPA1RLA class II histocompatibility antigen, DP alpha-1 chain-like isoform X1. (266 aa)
IL10RAInterleukin-10 receptor subunit alpha isoform X1. (578 aa)
HLA-DOAHLA class II histocompatibility antigen, DO alpha chain-like. (250 aa)
TLR9Toll-like receptor 9. (1031 aa)
ITGAMIntegrin alpha-M isoform X1. (1150 aa)
MAPK3Mitogen-activated protein kinase 1/3. (265 aa)
MAPK14Mitogen-activated protein kinase 14 isoform X1. (360 aa)
C3Complement C3 isoform X1. (1646 aa)
HLA-DRAHLA class II histocompatibility antigen, DR alpha chain. (254 aa)
APAF1Apoptotic protease-activating factor 1 isoform X1. (1250 aa)
CORO1ACoronin-1A isoform X1. (461 aa)
RAB7ARas-related protein Rab-7A. (207 aa)
LOC109260707LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DRB1-4 beta chain-like. (229 aa)
NOS2Nitric oxide synthase, inducible isoform X1. (1105 aa)
IL10Interleukin-10 isoform X1. (178 aa)
RELATranscription factor p65 isoform X1. (553 aa)
TGFB1Transforming growth factor beta-1 isoform X1. (390 aa)
PPP3CCSerine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1. (518 aa)
MAPK10Mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase). (531 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12 isoform X1. (1538 aa)
RFXANKRegulatory factor X-associated ankyrin-containing protein. (260 aa)
SRCProto-oncogene tyrosine-protein kinase Src isoform X1. (542 aa)
HLA-DMAHLA class II histocompatibility antigen, DM alpha chain. (261 aa)
TCIRG1-2LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a. (87 aa)
IFNGR1Interferon gamma receptor 1. (468 aa)
SPHK1Sphingosine kinase 1 isoform X1. (387 aa)
LOC109261022Complement component 3. (1654 aa)
TNFTumor necrosis factor superfamily, member 2. (233 aa)
LOC109271415HLA class II histocompatibility antigen, DM beta chain isoform X1. (263 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (968 aa)
RAB5BRas-related protein Rab-5B. (205 aa)
MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1. (826 aa)
CARD9Caspase recruitment domain-containing protein 9 isoform X1. (524 aa)
RAB5CRas-related protein Rab-5C. (216 aa)
MRC2C-type mannose receptor 2. (1479 aa)
IL1AInterleukin-1 alpha isoform X1. (262 aa)
IL1BInterleukin 1 beta. (267 aa)
IL12AInterleukin-12 subunit alpha isoform X1. (222 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (86 aa)
NFYANuclear transcription factor Y subunit alpha isoform X1. (347 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
VDRVitamin D3 receptor isoform X1. (441 aa)
IRAK2Interleukin-1 receptor-associated kinase-like 2 isoform X1. (618 aa)
ATP6V0D2V-type H+-transporting ATPase subunit d. (351 aa)
ATP6V0A2V-type proton ATPase 116 kDa subunit a isoform X1. (854 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta isoform X1. (533 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
BADBcl2-associated agonist of cell death. (169 aa)
LAMP1Lysosome-associated membrane glycoprotein 1. (413 aa)
HSPD160 kDa heat shock protein, mitochondrial. (573 aa)
TGFB3Transforming growth factor beta-3 isoform X1. (412 aa)
AKT1RAC-alpha serine/threonine-protein kinase isoform X1. (480 aa)
CTSSCathepsin S isoform X1. (331 aa)
AKT3RAC-gamma serine/threonine-protein kinase isoform X1. (479 aa)
FCGR3ALow affinity immunoglobulin gamma Fc region receptor III-A isoform X1. (243 aa)
IFNGInterferon gamma. (167 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (891 aa)
MAPK1Mitogen-activated protein kinase 1/3. (360 aa)
ATP6V0D1V-type H+-transporting ATPase subunit d. (351 aa)
EP300Histone acetyltransferase p300. (2420 aa)
PLA2R1Secretory phospholipase A2 receptor isoform X1. (1463 aa)
FCGR2BLow affinity immunoglobulin gamma Fc region receptor II-b isoform X1. (297 aa)
HLA-DOBHLA class II histocompatibility antigen, DO beta chain-like isoform X1. (272 aa)
NFYBNuclear transcription factor Y subunit beta isoform X1. (207 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1. (489 aa)
TLR4Toll-like receptor 4 isoform X1. (833 aa)
HSPA9Stress-70 protein, mitochondrial. (679 aa)
CYP27B1Calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase). (508 aa)
LOC109261307Interferon alpha. (189 aa)
LOC109261394H-2 class II histocompatibility antigen, E-S beta chain-like. (334 aa)
ATP6V0BV-type proton ATPase 21 kDa proteolipid subunit isoform X1. (205 aa)
CD14Monocyte differentiation antigen CD14. (375 aa)
TGFB2Transforming growth factor beta-2 isoform X1. (442 aa)
LOC109257074LOW QUALITY PROTEIN: high affinity immunoglobulin gamma Fc receptor I-like. (373 aa)
ATP6V1HV-type proton ATPase subunit H isoform X1. (483 aa)
CALML6Calmodulin-like protein 6 isoform X1. (180 aa)
STAT1Signal transducer and activator of transcription 1-alpha/beta. (750 aa)
CLEC7AC-type lectin domain family 7 member A isoform X1. (248 aa)
LSP1Lymphocyte-specific protein 1 isoform X1. (82 aa)
ATP6V0A1V-type proton ATPase 116 kDa subunit a isoform X1. (839 aa)
PPP3CASerine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1. (521 aa)
TRAF6TNF receptor-associated factor 6. (526 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1. (311 aa)
CTSDLOW QUALITY PROTEIN: cathepsin D. (384 aa)
CREBBPLOW QUALITY PROTEIN: CREB-binding protein. (2363 aa)
CASP3Caspase-3 isoform X1. (277 aa)
IL12BInterleukin-12 subunit beta isoform X1. (329 aa)
CASP8Caspase-8 isoform X1. (464 aa)
PPP3R1Serine/threonine-protein phosphatase 2B regulatory subunit. (188 aa)
LOC109261297DLA class II histocompatibility antigen, DR-1 beta chain-like. (247 aa)
LOC109272282CCAAT/enhancer binding protein (C/EBP), beta. (346 aa)
PLK3Serine/threonine-protein kinase PLK3 isoform X1. (638 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2. (538 aa)
LOC109262226Calmodulin-like. (143 aa)
TLR2Toll-like receptor 2. (784 aa)
LOC109257442Calmodulin-alpha-like. (86 aa)
IL23AInterleukin-23 subunit alpha isoform X1. (195 aa)
MAPK9Mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase). (424 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
ATP6AP1V-type proton ATPase subunit S1 isoform X1. (467 aa)
LBPLipopolysaccharide-binding protein-like isoform X1. (481 aa)
CALML5Calmodulin-like. (149 aa)
CALML3Calmodulin-like protein 3. (149 aa)
IFNB1Interferon beta. (186 aa)
LOC109247112Interferon alpha-2-like. (185 aa)
CEBPGCCAAT/enhancer binding protein (C/EBP), gamma. (146 aa)
CD74HLA class II histocompatibility antigen gamma chain isoform X1. (278 aa)
IFNGR2Interferon gamma receptor 2. (307 aa)
RFXAPRegulatory factor X-associated protein. (272 aa)
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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