STRINGSTRING
TRAF3 TRAF3 CCND1 CCND1 IFNAR1 IFNAR1 IRF9 IRF9 IFNAR2 IFNAR2 RIPK1 RIPK1 CDK6 CDK6 AKT2 AKT2 PIK3R1 PIK3R1 PPP2R2A PPP2R2A MYC MYC CLDN7 CLDN7 JAK1 JAK1 MAP2K1 MAP2K1 LOC109253093 LOC109253093 CTNNB1 CTNNB1 EGFR EGFR EIF2S1 EIF2S1 PIK3CB PIK3CB IKBKB IKBKB TLR3 TLR3 CLDN15 CLDN15 RXRA RXRA NR1H3 NR1H3 YWHAE YWHAE CLDN6 CLDN6 YWHAH YWHAH MAPK3 MAPK3 APAF1 APAF1 MAP2K2 MAP2K2 MX1 MX1 EIF2AK2 EIF2AK2 SOS2 SOS2 RELA RELA PPP2R2D PPP2R2D PIK3CA PIK3CA PPP2CA PPP2CA SOS1 SOS1 IRF3 IRF3 RNASEL RNASEL CLDN11 CLDN11 GRB2 GRB2 PPARA PPARA TNF TNF TBK1 TBK1 GSK3B GSK3B NFKB1 NFKB1 IRF7 IRF7 E2F3 E2F3 YWHAZ YWHAZ CHUK CHUK SOCS3 SOCS3 ARAF ARAF TRAF2 TRAF2 PIK3R2 PIK3R2 YWHAG YWHAG NRAS NRAS CDK2 CDK2 KRAS KRAS SCARB1 SCARB1 BAD BAD CLDN10 CLDN10 HRAS HRAS PPP2R1A PPP2R1A RB1 RB1 AKT1 AKT1 PIK3R3 PIK3R3 PIAS1 PIAS1 EIF2AK1 EIF2AK1 AKT3 AKT3 IFNG IFNG MAVS MAVS EIF2AK4 EIF2AK4 MAPK1 MAPK1 PSME3 PSME3 DDX58 DDX58 CLDN2 CLDN2 IKBKE IKBKE STAT3 STAT3 E2F1 E2F1 OAS3 OAS3 LOC109261307 LOC109261307 CDKN1A CDKN1A CLDN8 CLDN8 CLDN17 CLDN17 PPP2R2C PPP2R2C CD81 CD81 TYK2 TYK2 CLDN19 CLDN19 BAK1 BAK1 TP53 TP53 CLDN1 CLDN1 STAT1 STAT1 CDK4 CDK4 CXCL10 CXCL10 CFLAR CFLAR TRAF6 TRAF6 TRADD TRADD PPP2R2B PPP2R2B CASP3 CASP3 CASP8 CASP8 YWHAB YWHAB PPP2CB PPP2CB RSAD2 RSAD2 CLDN18 CLDN18 YWHAQ YWHAQ CLDN20 CLDN20 STAT2 STAT2 IKBKG IKBKG CLDN25 CLDN25 CLDN4 CLDN4 CLDN3 CLDN3 EIF3E EIF3E LOC109255377 LOC109255377 ENSPPRP00000027432 ENSPPRP00000027432 CLDN23 CLDN23 EGF EGF CLDN9 CLDN9 CLDN14 CLDN14 OCLN OCLN LOC109251044 LOC109251044 LOC109251043 LOC109251043 RAF1 RAF1 FASLG FASLG IFNB1 IFNB1 LOC109247112 LOC109247112 CLDN5 CLDN5 NFKBIA NFKBIA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAF3TNF receptor-associated factor 3 isoform X1. (568 aa)
CCND1G1/S-specific cyclin-D1. (295 aa)
IFNAR1Interferon alpha/beta receptor 1. (561 aa)
IRF9Interferon regulatory factor 9 isoform X1. (411 aa)
IFNAR2Interferon alpha/beta receptor 2 isoform X1. (519 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (671 aa)
CDK6Cyclin-dependent kinase 6. (326 aa)
AKT2RAC-beta serine/threonine-protein kinase. (481 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (725 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1. (457 aa)
MYCMyc proto-oncogene protein. (453 aa)
CLDN7Claudin-7. (211 aa)
JAK1Tyrosine-protein kinase JAK1. (1157 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1. (393 aa)
LOC109253093Apoptosis regulator BAX isoform X1. (192 aa)
CTNNB1Catenin beta 1. (781 aa)
EGFREpidermal growth factor receptor isoform X1. (1209 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit 1. (315 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta. (1070 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
TLR3Toll-like receptor 3. (904 aa)
CLDN15Claudin-15 isoform X1. (235 aa)
RXRARetinoic acid receptor RXR-alpha isoform X1. (453 aa)
NR1H3Oxysterols receptor LXR-alpha isoform X1. (447 aa)
YWHAE14-3-3 protein epsilon isoform X1. (255 aa)
CLDN6Claudin-6 isoform X1. (41 aa)
YWHAH14-3-3 protein gamma/eta. (246 aa)
MAPK3Mitogen-activated protein kinase 1/3. (265 aa)
APAF1Apoptotic protease-activating factor 1 isoform X1. (1250 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2 isoform X1. (400 aa)
MX1Interferon-induced GTP-binding protein Mx1-like. (655 aa)
EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinase isoform X1. (541 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1332 aa)
RELATranscription factor p65 isoform X1. (553 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1. (440 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta. (1068 aa)
PPP2CASerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform. (279 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1333 aa)
IRF3Interferon regulatory factor 3 isoform X1. (438 aa)
RNASEL2-5A-dependent ribonuclease isoform X1. (724 aa)
CLDN11Claudin-11. (207 aa)
GRB2Growth factor receptor-binding protein 2. (217 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (468 aa)
TNFTumor necrosis factor superfamily, member 2. (233 aa)
TBK1Serine/threonine-protein kinase TBK1 isoform X1. (729 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1. (433 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (968 aa)
IRF7Interferon regulatory factor 7 isoform X1. (225 aa)
E2F3Transcription factor E2F3 isoform X1. (463 aa)
YWHAZ14-3-3 protein beta/theta/zeta. (245 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (745 aa)
SOCS3Suppressor of cytokine signaling 3 isoform X1. (225 aa)
ARAFA-Raf proto-oncogene serine/threonine-protein kinase. (608 aa)
TRAF2TNF receptor-associated factor 2 isoform X1. (502 aa)
PIK3R2Phosphoinositide-3-kinase regulatory subunit alpha/beta/delta. (726 aa)
YWHAG14-3-3 protein gamma/eta. (247 aa)
NRASGTPase NRas. (189 aa)
CDK2Cyclin-dependent kinase 2 isoform X1. (346 aa)
KRASGTPase KRas isoform X1. (189 aa)
SCARB1Scavenger receptor class B member 1 isoform X1. (509 aa)
BADBcl2-associated agonist of cell death. (169 aa)
CLDN10Claudin-10 isoform X1. (229 aa)
HRASGTPase HRas. (171 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
RB1Retinoblastoma-associated protein isoform X1. (926 aa)
AKT1RAC-alpha serine/threonine-protein kinase isoform X1. (480 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit alpha/beta/delta. (461 aa)
PIAS1E3 SUMO-protein ligase PIAS1 isoform X1. (651 aa)
EIF2AK1Eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1. (641 aa)
AKT3RAC-gamma serine/threonine-protein kinase isoform X1. (479 aa)
IFNGInterferon gamma. (167 aa)
MAVSMitochondrial antiviral-signaling protein isoform X1. (523 aa)
EIF2AK4Eukaryotic translation initiation factor 2-alpha kinase 4. (1631 aa)
MAPK1Mitogen-activated protein kinase 1/3. (360 aa)
PSME3Proteasome activator complex subunit 3 isoform X1. (266 aa)
DDX58Probable ATP-dependent RNA helicase DDX58 isoform X1. (929 aa)
CLDN2Claudin-2. (230 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (719 aa)
STAT3Signal transducer and activator of transcription 3 isoform X1. (770 aa)
E2F1Transcription factor E2F1 isoform X1. (436 aa)
OAS3LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 3. (1087 aa)
LOC109261307Interferon alpha. (189 aa)
CDKN1ACyclin-dependent kinase inhibitor 1A. (164 aa)
CLDN8Claudin-8. (225 aa)
CLDN17Claudin-17. (219 aa)
PPP2R2CProtein phosphatase 2, regulatory subunit B, gamma isoform X1. (447 aa)
CD81CD81 antigen isoform X1. (236 aa)
TYK2Non-receptor tyrosine-protein kinase TYK2 isoform X1. (1181 aa)
CLDN19Claudin-19. (224 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
TP53Cellular tumor antigen p53. (386 aa)
CLDN1Claudin-1. (211 aa)
STAT1Signal transducer and activator of transcription 1-alpha/beta. (750 aa)
CDK4Cyclin-dependent kinase 4 isoform X1. (303 aa)
CXCL10C-X-C motif chemokine 10. (98 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform X1. (481 aa)
TRAF6TNF receptor-associated factor 6. (526 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1. (311 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1. (509 aa)
CASP3Caspase-3 isoform X1. (277 aa)
CASP8Caspase-8 isoform X1. (464 aa)
YWHAB14-3-3 protein beta/theta/zeta. (246 aa)
PPP2CBSerine/threonine-protein phosphatase 2A catalytic subunit beta isoform. (309 aa)
RSAD2Radical S-adenosyl methionine domain-containing protein 2 isoform X1. (363 aa)
CLDN18Claudin-18. (261 aa)
YWHAQ14-3-3 protein theta isoform X1. (245 aa)
CLDN20Claudin-20. (219 aa)
STAT2Signal transducer and activator of transcription 2 isoform X1. (855 aa)
IKBKGInhibitor of nuclear factor kappa-B kinase subunit gamma. (464 aa)
CLDN25Putative claudin-25. (228 aa)
CLDN4Claudin-4. (209 aa)
CLDN3Claudin-3. (218 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E isoform X1. (445 aa)
LOC109255377Interferon-induced protein with tetratricopeptide repeats 1B-like isoform X1. (472 aa)
ENSPPRP00000027432Interferon-induced protein with tetratricopeptide repeats 1-like isoform X1. (472 aa)
CLDN23Claudin-23. (291 aa)
EGFPro-epidermal growth factor isoform X1. (1203 aa)
CLDN9Claudin-9. (217 aa)
CLDN14Claudin-14 isoform X1. (236 aa)
OCLNOccludin isoform X1. (521 aa)
LOC109251044Claudin-22-like. (220 aa)
LOC109251043Putative claudin-24. (220 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
FASLGTumor necrosis factor ligand superfamily member 6. (278 aa)
IFNB1Interferon beta. (186 aa)
LOC109247112Interferon alpha-2-like. (185 aa)
CLDN5Claudin-5. (218 aa)
NFKBIANF-kappa-B inhibitor alpha. (314 aa)
Your Current Organism:
Panthera pardus
NCBI taxonomy Id: 9691
Other names: Leo pardus, P. pardus, leopard
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