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PNPLA8 PNPLA8 TPRA1 TPRA1 ADIPOQ ADIPOQ EMG1 EMG1 ADIG ADIG THAP1 THAP1 LOC101384189 LOC101384189 THY1 THY1 PPARG PPARG LOC101375046 LOC101375046 LEP LEP SLC2A4 SLC2A4 BOLA3 BOLA3 ACP2 ACP2 MRPL30 MRPL30 LOC101383672 LOC101383672 PNPLA2 PNPLA2 INS INS TUSC5 TUSC5 CEBPA CEBPA ABCC9 ABCC9 VCAN VCAN ASB14 ASB14 LOC101373381 LOC101373381 RRAS RRAS ACPT ACPT LDB3 LDB3 MANF MANF FABP4 FABP4 RSU1 RSU1 ENG ENG SLC25A51 SLC25A51
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PNPLA8Calcium-independent phospholipase A2-gamma isoform X1. (781 aa)
TPRA1Transmembrane protein adipocyte-associated 1. (367 aa)
ADIPOQAdiponectin isoform X1. (266 aa)
EMG1Ribosomal RNA small subunit methyltransferase NEP1. (244 aa)
ADIGAdipogenin. (73 aa)
THAP1THAP domain-containing protein 1. (213 aa)
LOC101384189Cytochrome c oxidase subunit 7A1, mitochondrial. (80 aa)
THY1Thy-1 membrane glycoprotein. (161 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (529 aa)
LOC101375046Cytochrome c oxidase subunit 7A1, mitochondrial. (80 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (508 aa)
BOLA3bolA-like protein 3 isoform X1; Belongs to the BolA/IbaG family. (110 aa)
ACP2Lysosomal acid phosphatase isoform X1; Belongs to the histidine acid phosphatase family. (423 aa)
MRPL3039S ribosomal protein L30, mitochondrial. (161 aa)
LOC101383672Cytochrome c oxidase protein 20 homolog. (119 aa)
PNPLA2Patatin-like phospholipase domain-containing protein 2. (486 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
TUSC5Tumor suppressor candidate 5. (230 aa)
CEBPACCAAT/enhancer-binding protein alpha. (354 aa)
ABCC9ATP-binding cassette sub-family C member 9 isoform X2. (1549 aa)
VCANVersican core protein isoform X1. (3400 aa)
ASB14Ankyrin repeat and SOCS box protein 14. (587 aa)
LOC101373381Bombesin receptor-activated protein C6orf89 homolog isoform X1. (387 aa)
RRASRas-related protein R-Ras. (218 aa)
ACPTTesticular acid phosphatase; Belongs to the histidine acid phosphatase family. (426 aa)
LDB3LIM domain-binding protein 3 isoform X1. (725 aa)
MANFMesencephalic astrocyte-derived neurotrophic factor. (179 aa)
FABP4Fatty acid-binding protein, adipocyte; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
RSU1Ras suppressor protein 1 isoform X1. (277 aa)
ENGEndoglin. (659 aa)
SLC25A51Solute carrier family 25 member 51; Belongs to the mitochondrial carrier (TC 2.A.29) family. (297 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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