node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADIPOQ | CEBPA | A0A2U3WVI3 | A0A2U3WAN3 | Adiponectin isoform X1. | CCAAT/enhancer-binding protein alpha. | 0.692 |
ADIPOQ | FABP4 | A0A2U3WVI3 | A0A2U3VGA8 | Adiponectin isoform X1. | Fatty acid-binding protein, adipocyte; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | 0.968 |
ADIPOQ | INS | A0A2U3WVI3 | A0A2U3W6R9 | Adiponectin isoform X1. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.767 |
ADIPOQ | LEP | A0A2U3WVI3 | A0A2U3VS59 | Adiponectin isoform X1. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.916 |
ADIPOQ | PPARG | A0A2U3WVI3 | A0A2U3VLH3 | Adiponectin isoform X1. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.779 |
ADIPOQ | SLC2A4 | A0A2U3WVI3 | A0A2U3VTD2 | Adiponectin isoform X1. | Solute carrier family 2, facilitated glucose transporter member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.763 |
ADIPOQ | UCP1 | A0A2U3WVI3 | A0A2U3WC13 | Adiponectin isoform X1. | Mitochondrial brown fat uncoupling protein 1 isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.433 |
ADIPOQ | UCP2 | A0A2U3WVI3 | A0A2U3VBF6 | Adiponectin isoform X1. | Mitochondrial uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.433 |
ADIPOQ | UCP3 | A0A2U3WVI3 | A0A2U3VBF4 | Adiponectin isoform X1. | Mitochondrial uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.433 |
ANGPTL4 | INS | A0A2U3WS89 | A0A2U3W6R9 | Angiopoietin-related protein 4 isoform X1. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.404 |
ANGPTL4 | PPARG | A0A2U3WS89 | A0A2U3VLH3 | Angiopoietin-related protein 4 isoform X1. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.576 |
CEBPA | ADIPOQ | A0A2U3WAN3 | A0A2U3WVI3 | CCAAT/enhancer-binding protein alpha. | Adiponectin isoform X1. | 0.692 |
CEBPA | FABP4 | A0A2U3WAN3 | A0A2U3VGA8 | CCAAT/enhancer-binding protein alpha. | Fatty acid-binding protein, adipocyte; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | 0.624 |
CEBPA | INS | A0A2U3WAN3 | A0A2U3W6R9 | CCAAT/enhancer-binding protein alpha. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.519 |
CEBPA | LEP | A0A2U3WAN3 | A0A2U3VS59 | CCAAT/enhancer-binding protein alpha. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.531 |
CEBPA | PPARG | A0A2U3WAN3 | A0A2U3VLH3 | CCAAT/enhancer-binding protein alpha. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.797 |
CEBPA | SLC2A4 | A0A2U3WAN3 | A0A2U3VTD2 | CCAAT/enhancer-binding protein alpha. | Solute carrier family 2, facilitated glucose transporter member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.537 |
ENG | THY1 | A0A2U3VDC0 | A0A2U3ZT56 | Endoglin. | Thy-1 membrane glycoprotein. | 0.760 |
FABP4 | ADIPOQ | A0A2U3VGA8 | A0A2U3WVI3 | Fatty acid-binding protein, adipocyte; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | Adiponectin isoform X1. | 0.968 |
FABP4 | CEBPA | A0A2U3VGA8 | A0A2U3WAN3 | Fatty acid-binding protein, adipocyte; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | CCAAT/enhancer-binding protein alpha. | 0.624 |