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UCP2 UCP2 PNPLA2 PNPLA2 MKNK1 MKNK1 SLC2A4 SLC2A4 LEP LEP PPARG PPARG TPRA1 TPRA1 FABP4 FABP4 RSU1 RSU1 ENG ENG INS INS UCP3 UCP3 ASB14 ASB14 LOC101373381 LOC101373381 RRAS RRAS MANF MANF ANGPTL4 ANGPTL4 ADIPOQ ADIPOQ THAP1 THAP1 THY1 THY1 UCP1 UCP1 CEBPA CEBPA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UCP2Mitochondrial uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
PNPLA2Patatin-like phospholipase domain-containing protein 2. (486 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1; Belongs to the protein kinase superfamily. (421 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (508 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (529 aa)
TPRA1Transmembrane protein adipocyte-associated 1. (367 aa)
FABP4Fatty acid-binding protein, adipocyte; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
RSU1Ras suppressor protein 1 isoform X1. (277 aa)
ENGEndoglin. (659 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
UCP3Mitochondrial uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (311 aa)
ASB14Ankyrin repeat and SOCS box protein 14. (587 aa)
LOC101373381Bombesin receptor-activated protein C6orf89 homolog isoform X1. (387 aa)
RRASRas-related protein R-Ras. (218 aa)
MANFMesencephalic astrocyte-derived neurotrophic factor. (179 aa)
ANGPTL4Angiopoietin-related protein 4 isoform X1. (412 aa)
ADIPOQAdiponectin isoform X1. (266 aa)
THAP1THAP domain-containing protein 1. (213 aa)
THY1Thy-1 membrane glycoprotein. (161 aa)
UCP1Mitochondrial brown fat uncoupling protein 1 isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
CEBPACCAAT/enhancer-binding protein alpha. (354 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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