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| | AK6 | Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (172 aa) |
| | RRM1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa) |
| | PDE2A | Phosphodiesterase. (943 aa) |
| | APRT | Adenine phosphoribosyltransferase. (180 aa) |
| | NPR2 | Guanylate cyclase. (1047 aa) |
| | PDE1A | Phosphodiesterase. (531 aa) |
| | UCK1 | Uridine-cytidine kinase 1 isoform X1. (281 aa) |
| | AK1 | Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (210 aa) |
| | AK8 | Adenylate kinase 8; Belongs to the adenylate kinase family. (479 aa) |
| | DCK | Deoxycytidine kinase isoform X1. (260 aa) |
| | TK1 | Thymidine kinase. (239 aa) |
| | NT5C | 5'(3')-deoxyribonucleotidase, cytosolic type. (211 aa) |
| | GUCY1A3 | Guanylate cyclase soluble subunit alpha-3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa) |
| | FAM181A | Protein FAM181A isoform X1. (343 aa) |
| | AMPD3 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (777 aa) |
| | ADCY3 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa) |
| | LOC101381906 | Nucleoside diphosphate kinase. (152 aa) |
| | LOC105757063 | Nucleoside diphosphate kinase. (152 aa) |
| | GNG7 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | ADSSL1 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (459 aa) |
| | NPPC | C-type natriuretic peptide. (126 aa) |
| | GNG10 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa) |
| | DCTPP1 | dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. (170 aa) |
| | ADSL | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (491 aa) |
| | ITPA | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (361 aa) |
| | PDE8A | Phosphodiesterase. (835 aa) |
| | HDDC3 | guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase MESH1. (179 aa) |
| | ENTPD6 | LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (472 aa) |
| | DGUOK | Deoxyguanosine kinase, mitochondrial isoform X1. (291 aa) |
| | NME6 | Nucleoside diphosphate kinase. (186 aa) |
| | IMPDH2 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa) |
| | ADSS | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa) |
| | HPRT1 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (176 aa) |
| | ENPP1 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (925 aa) |
| | ENPP3 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3. (873 aa) |
| | ATIC | Bifunctional purine biosynthesis protein PURH isoform X1. (594 aa) |
| | AMPD1 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (747 aa) |
| | PDE10A | Phosphodiesterase. (794 aa) |
| | UPP1 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (316 aa) |
| | PDE5A | Phosphodiesterase. (865 aa) |
| | RRM2 | Ribonucleoside-diphosphate reductase subunit M2 isoform X1. (392 aa) |
| | GMPR2 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (429 aa) |
| | ENTPD4 | Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (616 aa) |
| | PDE7A | Phosphodiesterase. (483 aa) |
| | RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B isoform X1. (351 aa) |
| | LOC101381565 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (227 aa) |
| | NT5C1A | Cytosolic 5'-nucleotidase 1A. (365 aa) |
| | NPR1 | Guanylate cyclase. (1080 aa) |
| | NME4 | Nucleoside diphosphate kinase. (187 aa) |
| | NME3 | Nucleoside diphosphate kinase. (169 aa) |
| | ADCY9 | Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1352 aa) |
| | PDE11A | Phosphodiesterase. (934 aa) |
| | PDE4C | Phosphodiesterase. (694 aa) |
| | NT5M | 5'(3')-deoxyribonucleotidase, mitochondrial. (187 aa) |
| | LOC101374608 | Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (172 aa) |
| | GMPR | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa) |
| | PDE1B | Phosphodiesterase. (496 aa) |
| | AK2 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (241 aa) |
| | PDE9A | Phosphodiesterase. (532 aa) |
| | CTPS1 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (591 aa) |
| | GUCA2A | Guanylin. (111 aa) |
| | CECR1 | Adenosine deaminase CECR1. (521 aa) |
| | GUCY2C | Guanylate cyclase. (1071 aa) |
| | ADK | Adenosine kinase. (305 aa) |
| | AMPD2 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (916 aa) |
| | PRKG2 | cGMP-dependent protein kinase. (762 aa) |
| | RAPGEF4 | Rap guanine nucleotide exchange factor 4 isoform X1. (1011 aa) |
| | NT5E | 5'-nucleotidase isoform X1; Belongs to the 5'-nucleotidase family. (574 aa) |
| | UCK2 | Uridine-cytidine kinase; Belongs to the uridine kinase family. (261 aa) |
| | NTPCR | Cancer-related nucleoside-triphosphatase. (190 aa) |
| | PDE4D | Phosphodiesterase. (811 aa) |
| | GNAL | Guanine nucleotide-binding protein G(Olf) subunit alpha isoform X1. (461 aa) |
| | XDH | Xanthine dehydrogenase/oxidase. (1333 aa) |
| | ADCY8 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa) |
| | UCKL1 | Uridine-cytidine kinase; Belongs to the uridine kinase family. (548 aa) |
| | PDE7B | cAMP-specific 3',5'-cyclic phosphodiesterase 7B; Belongs to the cyclic nucleotide phosphodiesterase family. (339 aa) |
| | AK5 | Adenylate kinase isoenzyme 5; Belongs to the adenylate kinase family. (561 aa) |
| | NT5C3B | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (300 aa) |
| | UPRT | Uracil phosphoribosyltransferase homolog. (304 aa) |
| | NPPA | Natriuretic peptides A. (152 aa) |
| | NPPB | Natriuretic peptides B. (132 aa) |
| | PDE8B | Phosphodiesterase. (891 aa) |
| | LOC101371928 | UMP-CMP kinase-like; Belongs to the adenylate kinase family. (237 aa) |
| | CDA | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa) |
| | AK4 | Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa) |
| | ENTPD3 | Ectonucleoside triphosphate diphosphohydrolase 3 isoform X1; Belongs to the GDA1/CD39 NTPase family. (529 aa) |
| | DTYMK | Thymidylate kinase isoform X1. (212 aa) |
| | GMPS | GMP synthase [glutamine-hydrolyzing] isoform X1. (699 aa) |
| | ENTPD2 | Ectonucleoside triphosphate diphosphohydrolase 2; Belongs to the GDA1/CD39 NTPase family. (495 aa) |
| | CMPK1 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (228 aa) |
| | GNAS | Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1. (1015 aa) |
| | GUCY1A2 | Guanylate cyclase soluble subunit alpha-2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (723 aa) |
| | NT5C3A | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (331 aa) |
| | PDE1C | Phosphodiesterase. (769 aa) |
| | DCTD | Deoxycytidylate deaminase. (178 aa) |
| | ADCY2 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa) |
| | NUDT16 | U8 snoRNA-decapping enzyme. (195 aa) |
| | SMIM19 | Small integral membrane protein 19 isoform X1. (107 aa) |
| | LOC101369893 | Cytosolic 5'-nucleotidase 1B isoform X1. (629 aa) |
| | LOC101365899 | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like. (164 aa) |
| | NME7 | Nucleoside diphosphate kinase 7; Belongs to the NDK family. (276 aa) |
| | AK3 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (223 aa) |
| | GUCY1B3 | Guanylate cyclase soluble subunit beta-1 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (643 aa) |
| | LOC101362994 | LOW QUALITY PROTEIN: adenylate kinase; Belongs to the adenylate kinase family. (370 aa) |
| | UPP2 | LOW QUALITY PROTEIN: uridine phosphorylase 2. (492 aa) |
| | RAPGEF3 | Rap guanine nucleotide exchange factor 3 isoform X1. (923 aa) |
| | ADCY5 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa) |
| | DUT | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1. (226 aa) |
| | GDA | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (469 aa) |
| | IMPDH1 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (574 aa) |
| | PDE4A | Phosphodiesterase. (871 aa) |
| | ENTPD5 | Ectonucleoside triphosphate diphosphohydrolase 5; Belongs to the GDA1/CD39 NTPase family. (428 aa) |
| | LOC101365290 | Guanylate cyclase soluble subunit beta-2-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (707 aa) |
| | NUDT2 | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]. (147 aa) |
| | ADCY6 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa) |
| | NT5C2 | Cytosolic purine 5'-nucleotidase isoform X1. (567 aa) |
| | ADCY4 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa) |
| | LOC105757534 | Phosphodiesterase. (427 aa) |
| | LOC101368838 | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa) |
| | GUCA2B | Guanylate cyclase activator 2B. (110 aa) |
| | AK9 | Adenylate kinase 9. (1887 aa) |
| | ADCY10 | Adenylate cyclase type 10 isoform X1. (1623 aa) |
| | ADCY7 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1077 aa) |
| | LOC101386612 | LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2-like. (394 aa) |
| | ADCY1 | Adenylate cyclase type 1. (907 aa) |
| | NPR3 | Atrial natriuretic peptide receptor 3 isoform X1. (537 aa) |
| | LOC101367891 | Guanylate cyclase. (1010 aa) |
| | PNP | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (275 aa) |
| | CTPS2 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (586 aa) |
| | LOC101382207 | LOW QUALITY PROTEIN: schlafen family member 12. (591 aa) |
| | NUDT12 | Peroxisomal NADH pyrophosphatase NUDT12 isoform X1. (461 aa) |
| | PDE3B | Phosphodiesterase. (1112 aa) |
| | PDE3A | Phosphodiesterase. (791 aa) |
| | ENTPD8 | Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (580 aa) |
| | ENTPD1 | Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (444 aa) |
| | LOC101363792 | Adenylate cyclase type 10-like. (1182 aa) |
| | AK7 | Adenylate kinase 7. (739 aa) |
| | CMPK2 | UMP-CMP kinase 2, mitochondrial. (381 aa) |
