25 items (Odobenus rosmarus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	CPEB4	Cytoplasmic polyadenylation element-binding protein 4 isoform X1. (729 aa)
	DICER1	Endoribonuclease Dicer isoform X1; Belongs to the helicase family. Dicer subfamily. (1923 aa)
	CPEB1	Cytoplasmic polyadenylation element-binding protein 1 isoform X1. (608 aa)
	FXR2	Fragile X mental retardation syndrome-related protein 2. (673 aa)
	AGO3	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
	AGO1	Protein argonaute-1 isoform X1; Belongs to the argonaute family. (857 aa)
	AGO4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (861 aa)
	MAP1B	Microtubule-associated protein 1B. (2471 aa)
	PRKRA	Interferon-inducible double-stranded RNA-dependent protein kinase activator A. (313 aa)
	TSN	Translin isoform X1. (228 aa)
	TSNAX	Translin-associated protein X. (290 aa)
	TARBP2	RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (366 aa)
	IPO8	Importin-8 isoform X1. (1037 aa)
	WDR86	WD repeat-containing protein 86. (396 aa)
	ARHGAP6	Rho GTPase-activating protein 6. (981 aa)
	DROSHA	Ribonuclease 3 isoform X1. (1374 aa)
	FMR1	Fragile X mental retardation protein 1 isoform X1. (632 aa)
	DGCR8	Microprocessor complex subunit DGCR8. (773 aa)
	TNRC6B	Trinucleotide repeat-containing gene 6B protein isoform X1. (1864 aa)
	FXR1	Fragile X mental retardation syndrome-related protein 1 isoform X1. (648 aa)
	TNRC6A	Trinucleotide repeat-containing gene 6A protein. (1988 aa)
	LOC101366593	LOW QUALITY PROTEIN: protein argonaute-2-like. (323 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (815 aa)
	CPEB3	Cytoplasmic polyadenylation element-binding protein 3 isoform X1. (720 aa)
	STAU1	Double-stranded RNA-binding protein Staufen homolog 1. (646 aa)

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO1	AGO2	A0A2U3W3V7	A0A2U3ZKX6	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.766
AGO1	DICER1	A0A2U3W3V7	A0A2U3VI99	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Endoribonuclease Dicer isoform X1; Belongs to the helicase family. Dicer subfamily.	0.860
AGO1	DROSHA	A0A2U3W3V7	A0A2U3WR15	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Ribonuclease 3 isoform X1.	0.772
AGO1	FMR1	A0A2U3W3V7	A0A2U3WWL3	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Fragile X mental retardation protein 1 isoform X1.	0.552
AGO1	FXR1	A0A2U3W3V7	A0A2U3ZDR7	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Fragile X mental retardation syndrome-related protein 1 isoform X1.	0.422
AGO1	FXR2	A0A2U3W3V7	A0A2U3VT89	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Fragile X mental retardation syndrome-related protein 2.	0.403
AGO1	IPO8	A0A2U3W3V7	A0A2U3WFY1	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Importin-8 isoform X1.	0.499
AGO1	LOC101366593	A0A2U3W3V7	A0A2U3ZKR2	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	LOW QUALITY PROTEIN: protein argonaute-2-like.	0.766
AGO1	PRKRA	A0A2U3W3V7	A0A2U3W6H7	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Interferon-inducible double-stranded RNA-dependent protein kinase activator A.	0.692
AGO1	STAU1	A0A2U3W3V7	A0A2U3ZU26	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Double-stranded RNA-binding protein Staufen homolog 1.	0.561
AGO1	TARBP2	A0A2U3W3V7	A0A2U3WCQ3	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...]	0.738
AGO1	TNRC6A	A0A2U3W3V7	A0A2U3ZF29	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Trinucleotide repeat-containing gene 6A protein.	0.806
AGO1	TNRC6B	A0A2U3W3V7	A0A2U3ZCU4	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Trinucleotide repeat-containing gene 6B protein isoform X1.	0.586
AGO1	TSN	A0A2U3W3V7	A0A2U3W914	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Translin isoform X1.	0.572
AGO1	TSNAX	A0A2U3W3V7	A0A2U3W9E8	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Translin-associated protein X.	0.567
AGO2	AGO1	A0A2U3ZKX6	A0A2U3W3V7	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	0.766
AGO2	AGO3	A0A2U3ZKX6	A0A2U3W3R9	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.766
AGO2	AGO4	A0A2U3ZKX6	A0A2U3W3W1	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.766
AGO2	DGCR8	A0A2U3ZKX6	A0A2U3WZG5	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Microprocessor complex subunit DGCR8.	0.526
AGO2	DICER1	A0A2U3ZKX6	A0A2U3VI99	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Endoribonuclease Dicer isoform X1; Belongs to the helicase family. Dicer subfamily.	0.952