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FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) | ||||
POT1 | Protection of telomeres protein 1. (653 aa) | ||||
LOC101362303 | LOW QUALITY PROTEIN: histone-binding protein RBBP4-like. (425 aa) | ||||
NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (728 aa) | ||||
MRE11A | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa) | ||||
ZNF827 | Zinc finger protein 827 isoform X1. (1083 aa) | ||||
POLD1 | DNA polymerase. (1107 aa) | ||||
LOC101383994 | Zinc finger and SCAN domain-containing protein 4-like. (422 aa) | ||||
ZSCAN4 | Zinc finger and SCAN domain-containing protein 4. (436 aa) | ||||
THOC7 | THO complex subunit 7 homolog isoform X1. (257 aa) | ||||
PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa) | ||||
PPP1R10 | Serine/threonine-protein phosphatase 1 regulatory subunit 10. (965 aa) | ||||
SLX4 | Structure-specific endonuclease subunit SLX4. (1757 aa) | ||||
THOC6 | THO complex subunit 6 homolog isoform X1. (372 aa) | ||||
OBFC1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (396 aa) | ||||
CDK2 | Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa) | ||||
ERCC1 | DNA excision repair protein ERCC-1 isoform X1. (350 aa) | ||||
ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (860 aa) | ||||
THOC5 | THO complex subunit 5 homolog. (694 aa) | ||||
CHEK1 | Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (476 aa) | ||||
LOC101371079 | Histone-binding protein RBBP4-like. (425 aa) | ||||
RAD51D | DNA repair protein RAD51 homolog 4 isoform X1. (328 aa) | ||||
SPO11 | Meiotic recombination protein SPO11 isoform X1. (396 aa) | ||||
LOC101367731 | Breast cancer type 2 susceptibility protein homolog. (342 aa) | ||||
RIF1 | Telomere-associated protein RIF1 isoform X1. (2477 aa) | ||||
LOC101366939 | Transcriptional regulator ATRX-like. (259 aa) | ||||
EID3 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (370 aa) | ||||
CHD4 | chromodomain-helicase-DNA-binding protein 4 isoform X1. (1912 aa) | ||||
MTA2 | Metastasis-associated protein MTA2 isoform X1. (668 aa) | ||||
RBBP7 | Histone-binding protein RBBP7 isoform X1. (469 aa) | ||||
TERF2IP | Telomeric repeat-binding factor 2-interacting protein 1. (401 aa) | ||||
TFIP11 | Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] (837 aa) | ||||
SMCHD1 | Structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1. (2002 aa) | ||||
TERT | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1117 aa) | ||||
WDR82 | WD repeat-containing protein 82. (313 aa) | ||||
ATRX | Transcriptional regulator ATRX. (2226 aa) | ||||
TP53BP1 | Tumor suppressor p53-binding protein 1. (1975 aa) | ||||
THOC1 | THO complex subunit 1. (657 aa) | ||||
GAR1 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (211 aa) | ||||
ZBTB48 | Zinc finger and BTB domain-containing protein 48. (688 aa) | ||||
DMC1 | Meiotic recombination protein DMC1/LIM15 homolog isoform X1; Belongs to the RecA family. (340 aa) | ||||
SUN2 | SUN domain-containing protein 2. (718 aa) | ||||
NSMCE2 | E3 SUMO-protein ligase NSE2. (247 aa) | ||||
CCDC155 | Protein KASH5. (565 aa) | ||||
RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (487 aa) | ||||
ERCC4 | DNA repair endonuclease XPF. (916 aa) | ||||
EZH2 | Histone-lysine N-methyltransferase EZH2 isoform X1. (751 aa) | ||||
LOC101384176 | Uncharacterized protein C15orf43 homolog. (221 aa) | ||||
WRNIP1 | ATPase WRNIP1 isoform X1. (663 aa) | ||||
TNKS | Poly [ADP-ribose] polymerase. (1328 aa) | ||||
WRN | Werner syndrome ATP-dependent helicase. (1405 aa) | ||||
RAD50 | DNA repair protein RAD50 isoform X1. (1312 aa) | ||||
XRCC1 | DNA repair protein XRCC1. (630 aa) | ||||
PML | Protein PML. (928 aa) | ||||
HAT1 | Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa) | ||||
SMC6 | Structural maintenance of chromosomes protein 6. (1097 aa) | ||||
LRIF1 | Ligand-dependent nuclear receptor-interacting factor 1. (762 aa) | ||||
BRCA2 | Breast cancer type 2 susceptibility protein. (3150 aa) | ||||
RBBP4 | Histone-binding protein RBBP4. (332 aa) | ||||
CBX5 | Chromobox protein homolog 5. (191 aa) | ||||
DHX36 | ATP-dependent RNA helicase DHX36 isoform X1. (1011 aa) | ||||
UPF1 | Regulator of nonsense transcripts 1. (1119 aa) | ||||
NSMCE4A | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (385 aa) | ||||
TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (433 aa) | ||||
RAD17 | Cell cycle checkpoint protein RAD17. (708 aa) | ||||
GATAD2B | Transcriptional repressor p66-beta. (593 aa) | ||||
TOX4 | TOX high mobility group box family member 4 isoform X1. (619 aa) | ||||
TINF2 | LOW QUALITY PROTEIN: TERF1-interacting nuclear factor 2. (485 aa) | ||||
NABP2 | SOSS complex subunit B1. (211 aa) | ||||
ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) | ||||
THOC3 | THO complex subunit 3. (351 aa) | ||||
DCLRE1B | 5' exonuclease Apollo. (538 aa) | ||||
XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa) | ||||
ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa) | ||||
RECQL4 | ATP-dependent DNA helicase Q4. (1183 aa) | ||||
RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) | ||||
CHEK2 | Serine/threonine-protein kinase Chk2 isoform X1. (583 aa) | ||||
LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1. (649 aa) | ||||
WRAP53 | Telomerase Cajal body protein 1. (532 aa) | ||||
CTC1 | CST complex subunit CTC1. (1217 aa) | ||||
BLM | Bloom syndrome protein isoform X1. (1428 aa) | ||||
SMC5 | Structural maintenance of chromosomes protein 5. (1107 aa) | ||||
NSMCE1 | Non-structural maintenance of chromosomes element 1 homolog isoform X1. (283 aa) | ||||
DOT1L | Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1705 aa) | ||||
SIRT6 | NAD-dependent protein deacetylase sirtuin-6. (359 aa) | ||||
PINX1 | PIN2/TERF1-interacting telomerase inhibitor 1. (316 aa) | ||||
POLR2B | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa) | ||||
KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa) | ||||
GALK1 | Galactokinase. (392 aa) | ||||
TEN1 | CST complex subunit TEN1. (121 aa) | ||||
ZBTB10 | Zinc finger and BTB domain-containing protein 10 isoform X1. (873 aa) | ||||
DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2. (1020 aa) | ||||
ACD | Adrenocortical dysplasia protein homolog. (453 aa) | ||||
TERF2 | Telomeric repeat-binding factor 2 isoform X1. (542 aa) | ||||
ORC2 | Origin recognition complex subunit 2. (578 aa) | ||||
CCDC79 | Telomere repeats-binding bouquet formation protein 1. (728 aa) | ||||
NABP1 | SOSS complex subunit B2. (204 aa) |