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FEN1 FEN1 POT1 POT1 LOC101362303 LOC101362303 NBN NBN MRE11A MRE11A ZNF827 ZNF827 POLD1 POLD1 LOC101383994 LOC101383994 ZSCAN4 ZSCAN4 THOC7 THOC7 PIF1 PIF1 PPP1R10 PPP1R10 SLX4 SLX4 THOC6 THOC6 OBFC1 OBFC1 CDK2 CDK2 ERCC1 ERCC1 ORC1 ORC1 THOC5 THOC5 CHEK1 CHEK1 LOC101371079 LOC101371079 RAD51D RAD51D SPO11 SPO11 LOC101367731 LOC101367731 RIF1 RIF1 LOC101366939 LOC101366939 EID3 EID3 CHD4 CHD4 MTA2 MTA2 RBBP7 RBBP7 TERF2IP TERF2IP TFIP11 TFIP11 SMCHD1 SMCHD1 TERT TERT WDR82 WDR82 ATRX ATRX TP53BP1 TP53BP1 THOC1 THOC1 GAR1 GAR1 ZBTB48 ZBTB48 DMC1 DMC1 SUN2 SUN2 NSMCE2 NSMCE2 CCDC155 CCDC155 RNF8 RNF8 ERCC4 ERCC4 EZH2 EZH2 LOC101384176 LOC101384176 WRNIP1 WRNIP1 TNKS TNKS WRN WRN RAD50 RAD50 XRCC1 XRCC1 PML PML HAT1 HAT1 SMC6 SMC6 LRIF1 LRIF1 BRCA2 BRCA2 RBBP4 RBBP4 CBX5 CBX5 DHX36 DHX36 UPF1 UPF1 NSMCE4A NSMCE4A TERF1 TERF1 RAD17 RAD17 GATAD2B GATAD2B TOX4 TOX4 TINF2 TINF2 NABP2 NABP2 ORC4 ORC4 THOC3 THOC3 DCLRE1B DCLRE1B XRCC5 XRCC5 ATM ATM RECQL4 RECQL4 RAD51 RAD51 CHEK2 CHEK2 LRWD1 LRWD1 WRAP53 WRAP53 CTC1 CTC1 BLM BLM SMC5 SMC5 NSMCE1 NSMCE1 DOT1L DOT1L SIRT6 SIRT6 PINX1 PINX1 POLR2B POLR2B KDM1A KDM1A GALK1 GALK1 TEN1 TEN1 ZBTB10 ZBTB10 DNA2 DNA2 ACD ACD TERF2 TERF2 ORC2 ORC2 CCDC79 CCDC79 NABP1 NABP1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
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FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
POT1Protection of telomeres protein 1. (653 aa)
LOC101362303LOW QUALITY PROTEIN: histone-binding protein RBBP4-like. (425 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (728 aa)
MRE11ADouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
ZNF827Zinc finger protein 827 isoform X1. (1083 aa)
POLD1DNA polymerase. (1107 aa)
LOC101383994Zinc finger and SCAN domain-containing protein 4-like. (422 aa)
ZSCAN4Zinc finger and SCAN domain-containing protein 4. (436 aa)
THOC7THO complex subunit 7 homolog isoform X1. (257 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa)
PPP1R10Serine/threonine-protein phosphatase 1 regulatory subunit 10. (965 aa)
SLX4Structure-specific endonuclease subunit SLX4. (1757 aa)
THOC6THO complex subunit 6 homolog isoform X1. (372 aa)
OBFC1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (396 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
ERCC1DNA excision repair protein ERCC-1 isoform X1. (350 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (860 aa)
THOC5THO complex subunit 5 homolog. (694 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (476 aa)
LOC101371079Histone-binding protein RBBP4-like. (425 aa)
RAD51DDNA repair protein RAD51 homolog 4 isoform X1. (328 aa)
SPO11Meiotic recombination protein SPO11 isoform X1. (396 aa)
LOC101367731Breast cancer type 2 susceptibility protein homolog. (342 aa)
RIF1Telomere-associated protein RIF1 isoform X1. (2477 aa)
LOC101366939Transcriptional regulator ATRX-like. (259 aa)
EID3Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (370 aa)
CHD4chromodomain-helicase-DNA-binding protein 4 isoform X1. (1912 aa)
MTA2Metastasis-associated protein MTA2 isoform X1. (668 aa)
RBBP7Histone-binding protein RBBP7 isoform X1. (469 aa)
TERF2IPTelomeric repeat-binding factor 2-interacting protein 1. (401 aa)
TFIP11Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] (837 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1. (2002 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1117 aa)
WDR82WD repeat-containing protein 82. (313 aa)
ATRXTranscriptional regulator ATRX. (2226 aa)
TP53BP1Tumor suppressor p53-binding protein 1. (1975 aa)
THOC1THO complex subunit 1. (657 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (211 aa)
ZBTB48Zinc finger and BTB domain-containing protein 48. (688 aa)
DMC1Meiotic recombination protein DMC1/LIM15 homolog isoform X1; Belongs to the RecA family. (340 aa)
SUN2SUN domain-containing protein 2. (718 aa)
NSMCE2E3 SUMO-protein ligase NSE2. (247 aa)
CCDC155Protein KASH5. (565 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (487 aa)
ERCC4DNA repair endonuclease XPF. (916 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X1. (751 aa)
LOC101384176Uncharacterized protein C15orf43 homolog. (221 aa)
WRNIP1ATPase WRNIP1 isoform X1. (663 aa)
TNKSPoly [ADP-ribose] polymerase. (1328 aa)
WRNWerner syndrome ATP-dependent helicase. (1405 aa)
RAD50DNA repair protein RAD50 isoform X1. (1312 aa)
XRCC1DNA repair protein XRCC1. (630 aa)
PMLProtein PML. (928 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (419 aa)
SMC6Structural maintenance of chromosomes protein 6. (1097 aa)
LRIF1Ligand-dependent nuclear receptor-interacting factor 1. (762 aa)
BRCA2Breast cancer type 2 susceptibility protein. (3150 aa)
RBBP4Histone-binding protein RBBP4. (332 aa)
CBX5Chromobox protein homolog 5. (191 aa)
DHX36ATP-dependent RNA helicase DHX36 isoform X1. (1011 aa)
UPF1Regulator of nonsense transcripts 1. (1119 aa)
NSMCE4ANon-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (385 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (433 aa)
RAD17Cell cycle checkpoint protein RAD17. (708 aa)
GATAD2BTranscriptional repressor p66-beta. (593 aa)
TOX4TOX high mobility group box family member 4 isoform X1. (619 aa)
TINF2LOW QUALITY PROTEIN: TERF1-interacting nuclear factor 2. (485 aa)
NABP2SOSS complex subunit B1. (211 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
THOC3THO complex subunit 3. (351 aa)
DCLRE1B5' exonuclease Apollo. (538 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
RECQL4ATP-dependent DNA helicase Q4. (1183 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X1. (583 aa)
LRWD1Leucine-rich repeat and WD repeat-containing protein 1. (649 aa)
WRAP53Telomerase Cajal body protein 1. (532 aa)
CTC1CST complex subunit CTC1. (1217 aa)
BLMBloom syndrome protein isoform X1. (1428 aa)
SMC5Structural maintenance of chromosomes protein 5. (1107 aa)
NSMCE1Non-structural maintenance of chromosomes element 1 homolog isoform X1. (283 aa)
DOT1LHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1705 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (359 aa)
PINX1PIN2/TERF1-interacting telomerase inhibitor 1. (316 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
GALK1Galactokinase. (392 aa)
TEN1CST complex subunit TEN1. (121 aa)
ZBTB10Zinc finger and BTB domain-containing protein 10 isoform X1. (873 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (1020 aa)
ACDAdrenocortical dysplasia protein homolog. (453 aa)
TERF2Telomeric repeat-binding factor 2 isoform X1. (542 aa)
ORC2Origin recognition complex subunit 2. (578 aa)
CCDC79Telomere repeats-binding bouquet formation protein 1. (728 aa)
NABP1SOSS complex subunit B2. (204 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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