STRINGSTRING
LOC101363366 LOC101363366 TERT TERT ATRX ATRX MTOR MTOR TP53INP1 TP53INP1 SUMO3 SUMO3 MLIP MLIP NSMCE2 NSMCE2 PTEN PTEN MORC3 MORC3 KLHL20 KLHL20 WDFY3 WDFY3 TOPORS TOPORS CDK9 CDK9 IKBKE IKBKE TP53INP2 TP53INP2 LOC101381898 LOC101381898 SIRT1 SIRT1 SUMO2 SUMO2 KAT6A KAT6A CALCOCO2 CALCOCO2 RNF4 RNF4 ACRC ACRC ATR ATR SMC5 SMC5 PARK7 PARK7 BLM BLM ISG20 ISG20 TP53 TP53 RPAIN RPAIN LRCH4 LRCH4 RB1 RB1 CHEK2 CHEK2 ELF4 ELF4 NR2C1 NR2C1 RAD51 RAD51 HIPK1 HIPK1 ZMYM2 ZMYM2 TRIM8 TRIM8 PPARGC1A PPARGC1A LOC101370219 LOC101370219 CASP8AP2 CASP8AP2 TOP3A TOP3A LOC101373164 LOC101373164 HIPK3 HIPK3 CBX5 CBX5 TDP2 TDP2 LOC101377981 LOC101377981 RNF111 RNF111 SMC6 SMC6 DAXX DAXX PML PML BASP1 BASP1 PIAS2 PIAS2 NBN NBN MRE11A MRE11A PIAS1 PIAS1 LOC105758097 LOC105758097 TP73 TP73 MAPK7 MAPK7 EIF3E EIF3E RPA1 RPA1 HSF1 HSF1 CHD3 CHD3 TRIM16 TRIM16 SATB1 SATB1 ZBTB16 ZBTB16 THAP1 THAP1 LOC101366939 LOC101366939 CHFR CHFR N4BP1 N4BP1 HIPK2 HIPK2 TP63 TP63 RFWD3 RFWD3 SQSTM1 SQSTM1 TOPBP1 TOPBP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101363366Small ubiquitin-related modifier. (95 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1117 aa)
ATRXTranscriptional regulator ATRX. (2226 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2559 aa)
TP53INP1Tumor protein p53-inducible nuclear protein 1 isoform X1. (239 aa)
SUMO3Small ubiquitin-related modifier. (111 aa)
MLIPMuscular LMNA-interacting protein isoform X1. (994 aa)
NSMCE2E3 SUMO-protein ligase NSE2. (247 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MORC3MORC family CW-type zinc finger protein 3. (939 aa)
KLHL20Kelch-like protein 20 isoform X1. (609 aa)
WDFY3WD repeat and FYVE domain-containing protein 3. (3526 aa)
TOPORSE3 ubiquitin-protein ligase Topors isoform X1. (1044 aa)
CDK9Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily. (488 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon. (718 aa)
TP53INP2Tumor protein p53-inducible nuclear protein 2. (221 aa)
LOC101381898Small ubiquitin-related modifier 2-like. (98 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (740 aa)
SUMO2Small ubiquitin-related modifier. (95 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1995 aa)
CALCOCO2Calcium-binding and coiled-coil domain-containing protein 2 isoform X1. (470 aa)
RNF4E3 ubiquitin-protein ligase RNF4. (190 aa)
ACRCAcidic repeat-containing protein. (457 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2644 aa)
SMC5Structural maintenance of chromosomes protein 5. (1107 aa)
PARK7Protein deglycase DJ-1. (189 aa)
BLMBloom syndrome protein isoform X1. (1428 aa)
ISG20Interferon-stimulated gene 20 kDa protein. (171 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
RPAINLOW QUALITY PROTEIN: RPA-interacting protein. (281 aa)
LRCH4Leucine-rich repeat and calponin homology domain-containing protein 4 isoform X1. (685 aa)
RB1Retinoblastoma-associated protein. (936 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X1. (583 aa)
ELF4ETS-related transcription factor Elf-4. (662 aa)
NR2C1Nuclear receptor subfamily 2 group C member 1. (605 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
HIPK1Homeodomain-interacting protein kinase 1. (1210 aa)
ZMYM2Zinc finger MYM-type protein 2. (1377 aa)
TRIM8Probable E3 ubiquitin-protein ligase TRIM8. (551 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (803 aa)
LOC101370219Small ubiquitin-related modifier. (95 aa)
CASP8AP2CASP8-associated protein 2. (1964 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (983 aa)
LOC101373164Small ubiquitin-related modifier. (95 aa)
HIPK3Homeodomain-interacting protein kinase 3 isoform X1. (1215 aa)
CBX5Chromobox protein homolog 5. (191 aa)
TDP2tyrosyl-DNA phosphodiesterase 2. (358 aa)
LOC101377981Small ubiquitin-related modifier. (95 aa)
RNF111E3 ubiquitin-protein ligase Arkadia isoform X1. (1001 aa)
SMC6Structural maintenance of chromosomes protein 6. (1097 aa)
DAXXDeath domain-associated protein 6 isoform X1. (757 aa)
PMLProtein PML. (928 aa)
BASP1Brain acid soluble protein 1. (219 aa)
PIAS2E3 SUMO-protein ligase PIAS2 isoform X1. (621 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (728 aa)
MRE11ADouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
PIAS1E3 SUMO-protein ligase PIAS1 isoform X1. (655 aa)
LOC105758097E3 ubiquitin-protein ligase Topors-like. (730 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (643 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (806 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (450 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
HSF1Heat shock factor protein 1 isoform X1. (555 aa)
CHD3LOW QUALITY PROTEIN: chromodomain-helicase-DNA-binding protein 3. (2000 aa)
TRIM16Tripartite motif-containing protein 16. (558 aa)
SATB1DNA-binding protein SATB. (795 aa)
ZBTB16Zinc finger and BTB domain-containing protein 16. (673 aa)
THAP1THAP domain-containing protein 1. (213 aa)
LOC101366939Transcriptional regulator ATRX-like. (259 aa)
CHFRE3 ubiquitin-protein ligase CHFR. (661 aa)
N4BP1NEDD4-binding protein 1. (896 aa)
HIPK2Homeodomain-interacting protein kinase 2 isoform X1. (1195 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (733 aa)
RFWD3E3 ubiquitin-protein ligase RFWD3. (774 aa)
SQSTM1Sequestosome-1. (439 aa)
TOPBP1DNA topoisomerase 2-binding protein 1. (1513 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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