node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADRA2B | ADRA2C | A0A2U3VWU6 | A0A2U3VMI8 | alpha-2B adrenergic receptor. | alpha-2C adrenergic receptor. | 0.407 |
ADRA2C | ADRA2B | A0A2U3VMI8 | A0A2U3VWU6 | alpha-2C adrenergic receptor. | alpha-2B adrenergic receptor. | 0.407 |
FGF1 | INS | A0A2U3VRM8 | A0A2U3W6R9 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.616 |
FGF1 | INSR | A0A2U3VRM8 | A0A2U3WSM4 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | Tyrosine-protein kinase receptor. | 0.675 |
FGF1 | PDGFB | A0A2U3VRM8 | A0A2U3ZDW0 | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | Platelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. | 0.419 |
INS | FGF1 | A0A2U3W6R9 | A0A2U3VRM8 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | 0.616 |
INS | INSR | A0A2U3W6R9 | A0A2U3WSM4 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Tyrosine-protein kinase receptor. | 0.999 |
INS | NTRK3 | A0A2U3W6R9 | A0A2U3VSS0 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Tyrosine-protein kinase receptor. | 0.438 |
INS | PDGFB | A0A2U3W6R9 | A0A2U3ZDW0 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Platelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. | 0.921 |
INSR | FGF1 | A0A2U3WSM4 | A0A2U3VRM8 | Tyrosine-protein kinase receptor. | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | 0.675 |
INSR | INS | A0A2U3WSM4 | A0A2U3W6R9 | Tyrosine-protein kinase receptor. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.999 |
INSR | PDGFB | A0A2U3WSM4 | A0A2U3ZDW0 | Tyrosine-protein kinase receptor. | Platelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. | 0.690 |
INSR | PDPK1 | A0A2U3WSM4 | A0A2U3W585 | Tyrosine-protein kinase receptor. | 3-phosphoinositide-dependent protein kinase 1 isoform X1. | 0.404 |
NTRK3 | INS | A0A2U3VSS0 | A0A2U3W6R9 | Tyrosine-protein kinase receptor. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.438 |
PDGFB | FGF1 | A0A2U3ZDW0 | A0A2U3VRM8 | Platelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] | 0.419 |
PDGFB | INS | A0A2U3ZDW0 | A0A2U3W6R9 | Platelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.921 |
PDGFB | INSR | A0A2U3ZDW0 | A0A2U3WSM4 | Platelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. | Tyrosine-protein kinase receptor. | 0.690 |
PDPK1 | INSR | A0A2U3W585 | A0A2U3WSM4 | 3-phosphoinositide-dependent protein kinase 1 isoform X1. | Tyrosine-protein kinase receptor. | 0.404 |