STRINGSTRING
ADRA2C ADRA2C FGF1 FGF1 NTRK3 NTRK3 ADRA2B ADRA2B ITGB1BP1 ITGB1BP1 PDPK1 PDPK1 INS INS ADRA2A ADRA2A GAS6 GAS6 INSR INSR RNASE4 RNASE4 PPIA PPIA PDGFB PDGFB OSBPL8 OSBPL8 LOC101364116 LOC101364116 LOC105757731 LOC105757731
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADRA2Calpha-2C adrenergic receptor. (474 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
NTRK3Tyrosine-protein kinase receptor. (838 aa)
ADRA2Balpha-2B adrenergic receptor. (443 aa)
ITGB1BP1Integrin beta-1-binding protein 1. (200 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ADRA2Aalpha-2A adrenergic receptor. (465 aa)
GAS6Growth arrest-specific protein 6. (674 aa)
INSRTyrosine-protein kinase receptor. (1381 aa)
RNASE4Ribonuclease 4; Belongs to the pancreatic ribonuclease family. (146 aa)
PPIAPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (164 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (242 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (902 aa)
LOC101364116LOW QUALITY PROTEIN: dynactin-associated protein-like. (360 aa)
LOC105757731Dynactin-associated protein-like. (154 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
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