(12 nodes) siRNA binding network (Odobenus rosmarus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	TLR7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1050 aa)
	LOC101366593	LOW QUALITY PROTEIN: protein argonaute-2-like. (323 aa)
	TARBP2	RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (366 aa)
	MBD2	LOW QUALITY PROTEIN: methyl-CpG-binding domain protein 2. (408 aa)
	PRKRA	Interferon-inducible double-stranded RNA-dependent protein kinase activator A. (313 aa)
	DHX9	ATP-dependent RNA helicase A isoform X1. (1277 aa)
	LOC101370160	Toll-like receptor 9 isoform X1. (1056 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (815 aa)
	TLR8	Toll-like receptor 8; Belongs to the Toll-like receptor family. (1039 aa)
	MECP2	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (499 aa)
	DICER1	Endoribonuclease Dicer isoform X1; Belongs to the helicase family. Dicer subfamily. (1923 aa)
	FMR1	Fragile X mental retardation protein 1 isoform X1. (632 aa)

Your Current Organism:

Odobenus rosmarus

NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	DHX9	A0A2U3ZKX6	A0A2U3VP84	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	ATP-dependent RNA helicase A isoform X1.	0.619
AGO2	DICER1	A0A2U3ZKX6	A0A2U3VI99	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Endoribonuclease Dicer isoform X1; Belongs to the helicase family. Dicer subfamily.	0.952
AGO2	FMR1	A0A2U3ZKX6	A0A2U3WWL3	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Fragile X mental retardation protein 1 isoform X1.	0.652
AGO2	PRKRA	A0A2U3ZKX6	A0A2U3W6H7	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Interferon-inducible double-stranded RNA-dependent protein kinase activator A.	0.727
AGO2	TARBP2	A0A2U3ZKX6	A0A2U3WCQ3	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...]	0.855
DHX9	AGO2	A0A2U3VP84	A0A2U3ZKX6	ATP-dependent RNA helicase A isoform X1.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.619
DHX9	DICER1	A0A2U3VP84	A0A2U3VI99	ATP-dependent RNA helicase A isoform X1.	Endoribonuclease Dicer isoform X1; Belongs to the helicase family. Dicer subfamily.	0.476
DHX9	LOC101366593	A0A2U3VP84	A0A2U3ZKR2	ATP-dependent RNA helicase A isoform X1.	LOW QUALITY PROTEIN: protein argonaute-2-like.	0.619
DICER1	AGO2	A0A2U3VI99	A0A2U3ZKX6	Endoribonuclease Dicer isoform X1; Belongs to the helicase family. Dicer subfamily.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.952
DICER1	DHX9	A0A2U3VI99	A0A2U3VP84	Endoribonuclease Dicer isoform X1; Belongs to the helicase family. Dicer subfamily.	ATP-dependent RNA helicase A isoform X1.	0.476
DICER1	FMR1	A0A2U3VI99	A0A2U3WWL3	Endoribonuclease Dicer isoform X1; Belongs to the helicase family. Dicer subfamily.	Fragile X mental retardation protein 1 isoform X1.	0.487
DICER1	LOC101366593	A0A2U3VI99	A0A2U3ZKR2	Endoribonuclease Dicer isoform X1; Belongs to the helicase family. Dicer subfamily.	LOW QUALITY PROTEIN: protein argonaute-2-like.	0.952
DICER1	PRKRA	A0A2U3VI99	A0A2U3W6H7	Endoribonuclease Dicer isoform X1; Belongs to the helicase family. Dicer subfamily.	Interferon-inducible double-stranded RNA-dependent protein kinase activator A.	0.990
DICER1	TARBP2	A0A2U3VI99	A0A2U3WCQ3	Endoribonuclease Dicer isoform X1; Belongs to the helicase family. Dicer subfamily.	RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...]	0.996
FMR1	AGO2	A0A2U3WWL3	A0A2U3ZKX6	Fragile X mental retardation protein 1 isoform X1.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.652
FMR1	DICER1	A0A2U3WWL3	A0A2U3VI99	Fragile X mental retardation protein 1 isoform X1.	Endoribonuclease Dicer isoform X1; Belongs to the helicase family. Dicer subfamily.	0.487
FMR1	LOC101366593	A0A2U3WWL3	A0A2U3ZKR2	Fragile X mental retardation protein 1 isoform X1.	LOW QUALITY PROTEIN: protein argonaute-2-like.	0.652
FMR1	MECP2	A0A2U3WWL3	A0A2U3WK53	Fragile X mental retardation protein 1 isoform X1.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.766
LOC101366593	DHX9	A0A2U3ZKR2	A0A2U3VP84	LOW QUALITY PROTEIN: protein argonaute-2-like.	ATP-dependent RNA helicase A isoform X1.	0.619
LOC101366593	DICER1	A0A2U3ZKR2	A0A2U3VI99	LOW QUALITY PROTEIN: protein argonaute-2-like.	Endoribonuclease Dicer isoform X1; Belongs to the helicase family. Dicer subfamily.	0.952