STRINGSTRING
TP53 TP53 SIRT6 SIRT6 ZBTB7A ZBTB7A PARP1 PARP1 SAMHD1 SAMHD1 RAD18 RAD18 ARPC4 ARPC4 NABP1 NABP1 VCP VCP RNF168 RNF168 RNF169 RNF169 RPA3 RPA3 INIP INIP ARPC5 ARPC5 ANKRD32 ANKRD32 RIF1 RIF1 RBBP8 RBBP8 LOC101384378 LOC101384378 RFWD3 RFWD3 LOC101373200 LOC101373200 SMCHD1 SMCHD1 PARP3 PARP3 TP53BP1 TP53BP1 ACTR3 ACTR3 CNTD1 CNTD1 PRPF19 PRPF19 DDB1 DDB1 PNKP PNKP RNF8 RNF8 ACTR3B ACTR3B RAD50 RAD50 POLH POLH REC114 REC114 SMC6 SMC6 SMARCA5 SMARCA5 UFL1 UFL1 ZGRF1 ZGRF1 XRCC4 XRCC4 SIRT7 SIRT7 WDR70 WDR70 INTS3 INTS3 LMNA LMNA NHEJ1 NHEJ1 ARPC2 ARPC2 POLL POLL FAM178A FAM178A HUS1 HUS1 TIMELESS TIMELESS NABP2 NABP2 SMARCAL1 SMARCAL1 TONSL TONSL RAD51 RAD51 WRAP53 WRAP53 LOC101374392 LOC101374392 SMC5 SMC5 APLF APLF WAS WAS ARPC3 ARPC3 NBN NBN MRE11A MRE11A ESCO2 ESCO2 FAM35A FAM35A ATF2 ATF2 PHF1 PHF1 FAM178B FAM178B LOC101365594 LOC101365594 LOC101386769 LOC101386769 SMARCAD1 SMARCAD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (359 aa)
ZBTB7AZinc finger and BTB domain-containing protein 7A. (588 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
SAMHD1Deoxynucleoside triphosphate triphosphohydrolase SAMHD1. (627 aa)
RAD18E3 ubiquitin-protein ligase RAD18 isoform X1. (500 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (186 aa)
NABP1SOSS complex subunit B2. (204 aa)
VCPTransitional endoplasmic reticulum ATPase isoform X1; Belongs to the AAA ATPase family. (806 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (570 aa)
RNF169E3 ubiquitin-protein ligase RNF169. (708 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
INIPSOSS complex subunit C. (116 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (154 aa)
ANKRD32Ankyrin repeat domain-containing protein 32 isoform X1. (1057 aa)
RIF1Telomere-associated protein RIF1 isoform X1. (2477 aa)
RBBP8DNA endonuclease RBBP8 isoform X1. (897 aa)
LOC101384378Checkpoint protein; Belongs to the HUS1 family. (245 aa)
RFWD3E3 ubiquitin-protein ligase RFWD3. (774 aa)
LOC101373200Protein PAXX isoform X1. (207 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1. (2002 aa)
PARP3Poly [ADP-ribose] polymerase. (531 aa)
TP53BP1Tumor suppressor p53-binding protein 1. (1975 aa)
ACTR3Actin-related protein 3 isoform X1; Belongs to the actin family. (418 aa)
CNTD1Cyclin N-terminal domain-containing protein 1. (329 aa)
PRPF19pre-mRNA-processing factor 19. (504 aa)
DDB1DNA damage-binding protein 1 isoform X1. (1193 aa)
PNKPBifunctional polynucleotide phosphatase/kinase. (521 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (487 aa)
ACTR3BActin-related protein 3B isoform X1; Belongs to the actin family. (418 aa)
RAD50DNA repair protein RAD50 isoform X1. (1312 aa)
POLHDNA polymerase eta isoform X1. (712 aa)
REC114Meiotic recombination protein REC114. (213 aa)
SMC6Structural maintenance of chromosomes protein 6. (1097 aa)
SMARCA5SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5. (1052 aa)
UFL1E3 UFM1-protein ligase 1. (793 aa)
ZGRF1Protein ZGRF1. (2126 aa)
XRCC4DNA repair protein XRCC4. (333 aa)
SIRT7NAD-dependent protein deacetylase sirtuin-7. (399 aa)
WDR70WD repeat-containing protein 70 isoform X1. (654 aa)
INTS3Integrator complex subunit 3. (1041 aa)
LMNALamin isoform X1; Belongs to the intermediate filament family. (688 aa)
NHEJ1Non-homologous end-joining factor 1. (296 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
FAM178AProtein FAM178A. (1171 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
TIMELESSProtein timeless homolog. (1207 aa)
NABP2SOSS complex subunit B1. (211 aa)
SMARCAL1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (960 aa)
TONSLTonsoku-like protein. (1372 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
WRAP53Telomerase Cajal body protein 1. (532 aa)
LOC101374392Uncharacterized protein C20orf196 homolog. (206 aa)
SMC5Structural maintenance of chromosomes protein 5. (1107 aa)
APLFAprataxin and PNK-like factor isoform X1. (516 aa)
WASwiskott-Aldrich syndrome protein. (501 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (728 aa)
MRE11ADouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
ESCO2N-acetyltransferase ESCO2. (614 aa)
FAM35AProtein FAM35A. (258 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
PHF1PHD finger protein 1 isoform X1. (608 aa)
FAM178BProtein FAM178B isoform X1. (642 aa)
LOC101365594Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (167 aa)
LOC101386769E3 ubiquitin-protein ligase RNF138. (209 aa)
SMARCAD1annotation not available (1028 aa)
Your Current Organism:
Odobenus rosmarus
NCBI taxonomy Id: 9708
Other names: O. rosmarus divergens, Odobenus rosmarus divergens, Pacific walrus
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.